Extremely low frequency magnetic field exposure modulates the diurnal rhythm of the pain threshold in mice

Choi, Yoon Mee; Jeong, Ji Hoon; Kim, Jeong Soo; Lee, Byung-Cheon; Je, Hyun Dong; Sohn, Uy Dong

doi:10.1002/bem.10094

Cited by 24 publications

(15 citation statements)

References 26 publications

(35 reference statements)

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“…This proposed mechanism perfectly explains several previously inexplicable data, such as alteration of circadian rhythms in laboratory animals and humans during extremely low frequency EM radiation exposure [61,62], and the pronounced increase in transcription in cells exposed to ELF EMF [63]. The latter authors also noticed changes in transcriptional and translational patterns induced by the ELF EM fields in exposed cells.…”

Section: Signaling Pathways Capable Of Implementing Bio-regulatory (Isupporting

confidence: 83%

Mechanisms of Geomagnetic Field Influence on Gene Expression Using Influenza as a Model System: Basics of Physical Epidemiology

Запорожан

Ponomarenko

2010

IJERPH

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Recent studies demonstrate distinct changes in gene expression in cells exposed to a weak magnetic field (MF). Mechanisms of this phenomenon are not understood yet. We propose that proteins of the Cryptochrome family (CRY) are “epigenetic sensors” of the MF fluctuations, i.e., magnetic field-sensitive part of the epigenetic controlling mechanism. It was shown that CRY represses activity of the major circadian transcriptional complex CLOCK/BMAL1. At the same time, function of CRY, is apparently highly responsive to weak MF because of radical pairs that periodically arise in the functionally active site of CRY and mediate the radical pair mechanism of magnetoreception. It is known that the circadian complex influences function of every organ and tissue, including modulation of both NF-κB- and glucocorticoids- dependent signaling pathways. Thus, MFs and solar cycles-dependent geomagnetic field fluctuations are capable of altering expression of genes related to function of NF-κB, hormones and other biological regulators. Notably, NF-κB, along with its significant role in immune response, also participates in differential regulation of influenza virus RNA synthesis. Presented data suggests that in the case of global application (example—geomagnetic field), MF-mediated regulation may have epidemiological and other consequences.

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Section: Signaling Pathways Capable Of Implementing Bio-regulatory (Isupporting

confidence: 83%

Mechanisms of Geomagnetic Field Influence on Gene Expression Using Influenza as a Model System: Basics of Physical Epidemiology

Запорожан

Ponomarenko

2010

IJERPH

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“…In a recent study, Choi et al [2003] show a decrease of nociceptive thresholds during the day on mice exposed to 1.5 mT, 60 Hz field, for 12 h daily, for 5 days. The authors assume that ELF magnetic fields affect diurnal rhythm of pain sensitivity by acting on the system that is associated with environmental LD cycle.…”

Section: Discussionmentioning

confidence: 91%

Low frequency therapeutic EMF differently influences experimental muscle pain in female and male subjects

Lyskov¹,

Kalezic²,

Markov³

et al. 2005

Bioelectromagnetics

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Effects of a pulsating, half sine wave magnetic field (MF) with a frequency of 100 pps and 15 mT rms flux density, generated by the MD TEMF device (EMF Therapeutics, Inc., Chattanooga), on subjective pain rating, heart rate, and arterial blood pressure were tested in a double blind, crossover design study employing experimental muscle pain. Each of 24 healthy volunteers (12 females and 12 males, 24.7 +/- 3.2 years of age) received painful stimulation induced by the infusion of 5% hypertonic saline (HS) into the erector spinae muscle during real and sham MF exposure, in counterbalanced order. Exposure to MF differently affects subjective pain estimates in females and males. MF exposure increased averaged pain level and time integral of pain ratings in females, whereas no statistically significant difference for these characteristics was found in males. Pain related elevation of systolic and diastolic blood pressure was observed during both real and sham EMF exposure in female and male subjects.

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“…Extremely low frequency (ELF, <300 Hz) magnetic field (MF) could affect a variety of behaviors and physiological functions in animals [Kumlin et al, 2005;Shin et al, 2007]. ELF-MF induced hyperalgesia during daytime in normal conditions with the involvement of melatonin and opiods [Choi et al, 2003]. The circadian parameters of circulating corticosterone were more labile during magnetic stormy days than during the last three quiet days, and the concomitantly assessed circadian melatonin rhythm was also altered by the occurrence of geomagnetic disturbances, the MESOR and circadian amplitude being decreased for pineal melatonin but increased for hypothalamic melatonin [Olah et al, 2008].…”

Section: Discussionmentioning

confidence: 99%

Behavioral change related to Wenchuan devastating earthquake in mice

Liu

Jiang

et al. 2009

Bioelectromagnetics

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It has been suggested that some animals are much more capable of perceiving certain kinds of geophysical stimuli which may precede earthquakes than humans, but the anecdotal phenomena or stories about unusual animal behaviors prior to an earthquake should be interpreted with objective data. During the Wenchuan magnitude 8.0 earthquake that happened in Wenchuan county (31.0 degrees north latitude, 103.4 degrees east longitude) of Sichuan province, China, on May 12, 2008, eight mice were monitored for locomotor activity and circadian rhythm in constant darkness with temperature 22-24 degrees C and humidity 55-65% for 38 days. The ongoing monitoring of locomotor activity of mice in our laboratory made it possible to design a posteriori study investigating whether the earthquake was associated with any change in animal behavior. Based on analyzing the recorded data with single cosinor, we found that the locomotor activity dramatically decreased in six of these eight mice on day 3 before the earthquake, and the circadian rhythm of their locomotor activity was no longer detected. The behavioral change lasted for 6 days before the locomotor activity returned to its original state. Analyses of concurrent geomagnetic data showed a higher total intensity during the span when the circadian rhythm in locomotor activity weakened. These results indicated that the behaviors, including circadian rhythm and activity, in these mice indeed changed prior to the earthquake, and the behavioral change might be associated with a change of geomagnetic intensity.

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Extremely low frequency magnetic field exposure modulates the diurnal rhythm of the pain threshold in mice

Cited by 24 publications

References 26 publications

Mechanisms of Geomagnetic Field Influence on Gene Expression Using Influenza as a Model System: Basics of Physical Epidemiology

Mechanisms of Geomagnetic Field Influence on Gene Expression Using Influenza as a Model System: Basics of Physical Epidemiology

Low frequency therapeutic EMF differently influences experimental muscle pain in female and male subjects

Behavioral change related to Wenchuan devastating earthquake in mice

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