Recent studies demonstrate distinct changes in gene expression in cells exposed to a weak magnetic field (MF). Mechanisms of this phenomenon are not understood yet. We propose that proteins of the Cryptochrome family (CRY) are “epigenetic sensors” of the MF fluctuations, i.e., magnetic field-sensitive part of the epigenetic controlling mechanism. It was shown that CRY represses activity of the major circadian transcriptional complex CLOCK/BMAL1. At the same time, function of CRY, is apparently highly responsive to weak MF because of radical pairs that periodically arise in the functionally active site of CRY and mediate the radical pair mechanism of magnetoreception. It is known that the circadian complex influences function of every organ and tissue, including modulation of both NF-κB- and glucocorticoids- dependent signaling pathways. Thus, MFs and solar cycles-dependent geomagnetic field fluctuations are capable of altering expression of genes related to function of NF-κB, hormones and other biological regulators. Notably, NF-κB, along with its significant role in immune response, also participates in differential regulation of influenza virus RNA synthesis. Presented data suggests that in the case of global application (example—geomagnetic field), MF-mediated regulation may have epidemiological and other consequences.

No abstract

Устатті викладено15-річний досвідвикладання студентам-іноземцяманглійською мовоюі відображеноактивнуміжна-<br />родну діяльність науково-педагогічного складу університету з інтеграції медичної освіти України у Світовий освітній<br />простір.

PURPOSE: The aim of this article was to determine the features of pathomorphological changes in testicles and uterus of rats associated with thyroid hormone (TH) levels. MATERIAL AND METHODS: Experimental dysfunction of thyroid gland was induced in rats by daily administration of thyroxin in a dose of 50 ug/100 g (hyperthyroidism) and mercazolil in a dose of 5 ug/100g (hypothyroidism). Thyroid and sex hormone profiles were determined. Microscopy and morphometry of testicles in males and uterus in females were performed. The quantity of spermatids and spermatozoa as well as total number of spermatogenic cells was calculated. RESULTS: Hypothyroidism reduced TH concentrations in female rats and increased sex hormones while hyperthyroidism augmented TH and sex hormone levels. In hypothyroid male rats, a decreased TH and unchanged testosterone levels were found out while in hyperthyroid ones there were increased TH and decreased testosterone levels. There was a gender difference in terms of TH changes in hyperthyroidism, i.e. T3 and T4 elevation was more outlined in male than in female rats. The most significant histopathological changes were established in the uterus of hyperthyroid female rats and presented with signs of an acute vascular insufficiency, inflammation, hypertension and fibrosis. Hypothyroidism exerted a crucial effect on pathomorphological changes in rat testicles consisting in atrophy of spermatogenic epithelium, vascular insufficiency, hypertension and fibrosis as well. CONCLUSION: TH level significantly influences on the pathomorphological changes in the male and female reproductive system.

Ìàòåð³àëè Âñåóêðà¿íñüêî¿ íàâ÷àëüíî-íàóêîâî¿ êîíôåðåíö³¿ ç ì³aeíàðîäíîþ ó÷àñòþ Äîñÿãíåííÿ ³ ïåðñïåêòèâè âïðîâàäaeåííÿ êðåäèòíî-ìîäóëüíî¿ ñèñòåìè îðãàí³çàö³¿ íàâ÷àëüíîãî ïðîöåñó ó âèùèõ ìåäè÷íèõ (ôàðìàöåâòè÷íîìó) Odesa National Medical UniversityÌåäè÷íà ãàëóçü, ñòàí ÿêî¿ ï³äëÿãຠðåôîðìóâàííþ, ïîòðåáóº ë³êàðÿ íîâî¿ ôîðìàö³¿, ÿêèé, êð³ì òåîðåòè÷íèõ, ìຠøèðîê³ ïðàêòè÷í³ êîìïåòåíö³¿, ùî ôîðìóþòüñÿ çà äîïîìîãîþ âèêîðèñòàííÿ ñó÷àñíèõ ³ííîâàö³éíèõ òåõíîëîã³é. Ìîâà éäå ïðî âïðîâàäaeåííÿ â ïðàêòèêó ³ ðîçøèðåííÿ ìåðåae³ óí³âåðñèòåòñüêèõ êë³í³ê, ñòâîðåííÿ ñèìóëÿö³éíèõ öåíòð³â, åëåêòðîí-íèõ á³áë³îòåê òà ³í. ñó÷àñíî¿ ³íôðàñòðóêòóðè, ÿêà â ïîâí³é ì³ð³ ìຠçàáåçïå÷èòè ï³äãîòîâêó ë³êàðÿ íîâî¿ ÿêîñò³.  ïåðñïåêòèâ³ âèù³ ìåäè÷í³ íàâ÷àëüí³ çàêëàäè ìàþòü ïåðåòâîðèòèñÿ ó á³îìåäè÷í³ ³ííîâàö³éíî-òåõíîëîã³÷í³ êëàñòåðè.Medicine is the subject to reform now. It needs a doctor of a new breed, who, besides of theoretical, has wide practical knowledge forming due to modern innovative technologies. The question is about introduction into practice and expansion of the university clinics system, creation of simulation centers, electronic libraries, etc. a modern infrastructure, which should completely provide a modern doctor training. In the long view the higher medical educational institutions have to change into the biomedical innovative technology clusters.Âñòóï. Íàì íå ðàç äîâîäèëîñÿ ÷óòè êðèòèêó íà àäðåñó íàøî¿ ãàëóç³. ² öå íå äèâíî. Îõîðîíà çäîðîâÿ â Óêðà¿í³ çàéìຠïåðøå ì³ñöå â ðåéòèíãó ñåðåä ñîö³-àëüíèõ, ïîë³òè÷íèõ òà åêîíîì³÷íèõ ïðîáëåì, ùî ³ñíó-þòü ó äåðaeàâ³. 95 % íàñåëåííÿ òóðáóþòü ñàìå ïè-òàííÿ íàøî¿ ãàëóç³. ² öå çðîçóì³ëî, áî â íàø³é êðà¿í³ îñòàíí³ 1012 ðîê³â ñêëàëàñÿ íåïðîñòà ñèòóàö³ÿ ³ç ñòàíîì çäîðîâÿ íàñåëåííÿ, îñíîâí³ ïîêàçíèêè ÿêî-ãî ñåðåäíÿ òðèâàë³ñòü aeèòòÿ, ð³âåíü çàõâîðþâàíîñò³ òà ñìåðòíîñò³ äàëåêî íå îïòèì³ñòè÷í³ ³ ìàþòü òåí-äåíö³þ äî ïîã³ðøåííÿ, îñîáëèâî öå ñòîñóºòüñÿ ñåð-öåâî-ñóäèííèõ çàõâîðþâàíü, îíêîëî㳿, äèòÿ÷î¿ òà ïå-ðåä÷àñíî¿ ñìåðòíîñò³, çà ÿêèìè íàøà êðà¿íà óäâ³÷³ ïîïåðåäó âñ³º¿ ªâðîïè. Åï³äåì³ÿ òóáåðêóëüîçó, çá³ëüøåííÿ íàðêîìàí³¿, ²Ë-çàõâîðþâàíü, çíèaeåííÿ íàðîäaeóâàíîñò³ íà òë³ çðîñòàííÿ ñìåðòíîñò³ âñå öå ìຠì³ñöå ðàçîì ³ç îáìåaeåííÿì äîñòóïíîñò³ äëÿ á³ëüøîñò³ íàñåëåííÿ äî áåçîïëàòíî¿ ìåäèöèíè, ïî-ã³ðøåííÿì ÿêîñò³ ìåäè÷íèõ ïîñëóã, íåäîñòàòêîì ìå-äè÷íèõ êàäð³â.Àëå ïðè öüîìó â Óêðà¿í³ ê³ëüê³ñòü óñòàíîâ îõîðîíè çäîðîâÿ óäâ³÷³ á³ëüøà, í³ae ó êðà¿íàõ ªÑ, çà ê³ëüê³ñòþ ë³aeêî-ì³ñöü ìè â ï³âòîðàäâà ðàçè âèïåðåäaeàºìî ªâðîïó ó íàñ 91 ë³aeêî-ì³ñöå íà 10 òèñÿ÷ íàñåëåí-íÿ, â ªÑ 55.Óñå öå ðàçîì ³ç õðîí³÷íèì íåäîô³íàíñóâàííÿì âè-çíà÷èëî åêîíîì³÷íó íååôåêòèâí³ñòü ³ ãðîì³çäê³ñòü íàøî¿ ñèñòåìè îõîðîíè çäîðîâÿ, ùî ïðèçâåëî äî ¿¿ çóáîae³ííÿ ³ çàíåïàäó.Íàéá³ëüøå íåùàñòÿ äëÿ ë³êàðÿ, êîëè â³í çíàº, ùî òðåáà ðîáèòè, â쳺 öå ðîáèòè, àëå éîìó íåìà ÷èì öå ðîáèòè. Íàéá³ëüøà òðàãåä³ÿ äëÿ äåðaeàâè, êîëè ÷å-ðåç â³äñóòí³ñòü ³íñòðóìåíòàð³þ àáî ë³ê³â ãèíóòü ëþäè. Àëå íàéá³ëüøå ðîç÷àðóâàííÿ, çâè÷àéíî, ó ïàö³ºíò³â, ÿêèì íåìà äå îòðèìàòè êâàë³ô³êîâàíó äîïîìîãó.Ðåàë³çàö³ÿ ìåäè÷íî¿ ðåôîðìè â Óêðà¿í³ ðîçïî÷à-ëàñü, àëå ïîòðåáóº ³ñòîòíèõ êîðåêò...