Extremely low frequency magnetic field induces human neuronal differentiation through NMDA receptor activation

Özgün, Alp; Marote, Ana; Behie, Leo A.; Salgado, António J.; Gari̇pcan, Bora

doi:10.1007/s00702-019-02045-5

Cited by 23 publications

(15 citation statements)

References 71 publications

(97 reference statements)

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“…it is known that tryptophan residues of the NMDAR play key roles in channel gating 481,482 . Moreover, exposure to low-intensity magnetic fields activates the NMDAR 225,242,268 .…”

Section: /72mentioning

confidence: 99%

“…In that work, 100 µT induced more oxidative stress compared to 50 µT 224 . Furthermore, Özgün et al reported that exposure to a magnetic field (1 mT, 50 Hz) in vitro induced human neuronal differentiation through N-methyl-d-aspartate (NMDA) receptor activation 225 . They observed that magnetic field enhanced intracellular Ca 2+ levels.…”

Section: Low-frequencymentioning

confidence: 99%

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Magnetic field effects in biology from the perspective of the radical pair mechanism

Zadeh-Haghighi¹,

Simon²

2022

Preprint

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A large and growing body of research shows that weak magnetic fields can significantly influence various biological systems, including plants, animals, and humans. However, the underlying mechanisms behind these phenomena remain elusive. It is remarkable that the magnetic energies implicated in these effects are much smaller than thermal energies. Here we review these observations, of which there are now hundreds, and we suggest that a viable explanation is provided by the radical pair mechanism, which involves the quantum dynamics of the electron and nuclear spins of naturally occurring transient radical molecules. While the radical pair mechanism has been studied in detail in the context of avian magnetoreception, the studies reviewed here show that magnetosensitivity is widespread throughout biology. We review magnetic field effects on various physiological functions, organizing them based on the type of the applied magnetic fields, namely static, hypomagnetic, and oscillating magnetic fields, as well as isotope effects. We then review the radical pair mechanism as a potential unifying model for the described magnetic field effects, and we discuss plausible candidate molecules that might constitute the radical pairs. We review recent studies proposing that the quantum nature of the radical pairs provides promising explanations for xenon anesthesia, lithium effects on hyperactivity, magnetic field and lithium effects on the circadian clock, and hypomagnetic field effects on neurogenesis and microtubule assembly. We conclude by discussing future lines of investigation in this exciting new area of quantum biology related to weak magnetic field effects.

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“…it is known that tryptophan residues of the NMDAR play key roles in channel gating 481,482 . Moreover, exposure to low-intensity magnetic fields activates the NMDAR 225,242,268 .…”

Section: /72mentioning

confidence: 99%

Section: Low-frequencymentioning

confidence: 99%

Magnetic field effects in biology from the perspective of the radical pair mechanism

Zadeh-Haghighi¹,

Simon²

2022

Preprint

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“…ELF-EMFs have been shown to influence cell migration and proliferation, and regulate mitogen activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK), promoting the following angiogenic process. In vitro and in vivo experiments revealed that ELF-EMFs impact the modulation of VEGF-dependent signal transduction pathways and increase the number of angiogenesis factors [ 64 , 65 , 66 , 67 ]. Furthermore, Fan et al showed that ELF-EMFs may increase the proliferation of Human Bone Marrow Stromal Osteoprogenitor Cells (hBM-SCs), promoting DNA synthesis and increasing the proportion of cells in the S phase, and up-regulating the expressions of hematopoietic growth factors both in hBM-SCs and mesenchymal stem cells (MSC) [ 68 ].…”

Section: Emf-elf and Wound-repair: Mechanism Of Actionmentioning

confidence: 99%

Wound Repair and Extremely Low Frequency-Electromagnetic Field: Insight from In Vitro Study and Potential Clinical Application

Gualdi

Costantini

Reale

et al. 2021

IJMS

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Wound healing is a complex, staged process. It involves extensive communication between the different cellular constituents of various compartments of the skin and its extracellular matrix (ECM). Different signaling pathways are determined by a mutual influence on each other, resulting in a dynamic and complex crosstalk. It consists of various dynamic processes including a series of overlapping phases: hemostasis, inflammation response, new tissue formation, and tissue remodeling. Interruption or deregulation of one or more of these phases may lead to non-healing (chronic) wounds. The most important factor among local and systemic exogenous factors leading to a chronic wound is infection with a biofilm presence. In the last few years, an increasing number of reports have evaluated the effects of extremely low frequency (ELF) electromagnetic fields (EMFs) on tissue repair. Each experimental result comes from a single element of this complex process. An interaction between ELF-EMFs and healing has shown to effectively modulate inflammation, protease matrix rearrangement, neo-angiogenesis, senescence, stem-cell proliferation, and epithelialization. These effects are strictly related to the time of exposure, waveform, frequency, and amplitude. In this review, we focus on the effect of ELF-EMFs on different wound healing phases.

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“…system. It is reported that low-frequency magnetic fields: (i) can active N-methyl-D-aspartate receptors in glutamatergic Ca 2+ channels to promote neuronal differentiation (Ozgun et al, 2019); (ii) may improve depressant behavior and cognitive dysfunction mainly by modulating synaptic function (Yang et al, 2019). However, repeated stimulations of intracranial nerves may bring inestimable side effects, and the penetration depth is relatively limited.…”

Section: Acikan Et Al 2018 Distraction Osteogenesismentioning

confidence: 99%

Magnetic Materials in Promoting Bone Regeneration

et al. 2019

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Strategies to promote bone regeneration have been always the focus of investigations since the skeleton plays important roles like mechanical support, organ protection, and mineral homeostasis maintenance in the normal physiological activities of the human body. Magnetic fields have shown to be highly influential in the regeneration process, arousing tremendous interest in utilizing magnetic materials to enhance osteogenesis. In this work, we attempt a more comprehensive and detailed review of magnetic materials in promoting bone regeneration by including not only the mechanisms of bone regeneration, the history and basic concepts of magnetism, but also the types of magnetic materials as well as their influence parameters, designs and fabrication techniques with a focus on their usage in the field of bone regeneration like 3D printed scaffolds and implants. In addition, we provide some possible ideas on the synergistic action between magnetic and other materials on bone tissue. Finally, we propose the development trend of magnetic materials in the field of bone regeneration in the future. There is a huge demand for a more effective and less traumatic way to accelerate bone regeneration of the patients with diseases like fractures, tumors and osteoporosis that cause severe pains, bone loss, limb deformations, and restrictions of mobility. Magnetic materials have substantial potential to be manufactured into novel clinical applications with the ability to increase the bone regeneration efficiency.

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Extremely low frequency magnetic field induces human neuronal differentiation through NMDA receptor activation

Cited by 23 publications

References 71 publications

Magnetic field effects in biology from the perspective of the radical pair mechanism

Magnetic field effects in biology from the perspective of the radical pair mechanism

Wound Repair and Extremely Low Frequency-Electromagnetic Field: Insight from In Vitro Study and Potential Clinical Application

Magnetic Materials in Promoting Bone Regeneration

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