Extremely High-Frequency Therapy in Oncology

Teppone, Mikhail; Avakyan, Romen

doi:10.1089/acm.2009.0208

Cited by 14 publications

(13 citation statements)

References 5 publications

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“…Previously studies demonstrated millimeter wave radiation in treatment for various types of malignant tumors. The main indications for this therapy are prevention of metastases, relapses, and dissemination of the tumor; prevention and treatment of side-effects and complications from chemotherapy and radiotherapy; and treatment of the paraneoplastic syndrome (6,7). However, the molecular mechanism of millimeter wave radiation therapeutic effect is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Millimeter wave radiation induces apoptosis via affecting the ratio of Bax/Bcl-2 in SW1353 human chondrosarcoma cells

Ye²,

Cai³

et al. 2011

Oncol Rep

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Abstract. The efficacy and safety of millimeter wave radiation has been proven for various types of malignant tumors. However, the mechanisms underlying effects of millimeter wave radiation on apoptosis are still unclear. The present study was undertaken to examine the effects of millimeter wave radiation on cell apoptosis and mitochondrial membrane potential, and to determine the molecular mechanism of millimeter wave radiation-induced apoptosis by investigating the expression of Bcl-2 family proteins (Bcl-2, Bax), caspase-9 and caspase-3 in SW1353 cells. We found that millimeter wave radiation suppressed the viability of SW1353 cells, demonstrating that millimeter wave radiation induced cell apoptosis and reduced cell viability in a time-dependent manner. Furthermore, we observed that treatment of cells with millimeter wave radiation significantly induced loss of mitochondrial membrane potential, upregulated proapoptotic Bax, caspase-9 and caspase-3, but did not significantly change levels of antiapoptotic Bcl-2. These data suggested that millimeter wave radiation may induce apoptosis via affecting the ratio of Bax/Bcl-2 in SW1353 cells.

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Section: Introductionmentioning

confidence: 99%

Millimeter wave radiation induces apoptosis via affecting the ratio of Bax/Bcl-2 in SW1353 human chondrosarcoma cells

Ye²,

Cai³

et al. 2011

Oncol Rep

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“…The interaction of biological cells with millimeter waves (MMW) has been under investigation for several decades as potential cancer therapy. MMW irradiation has been in wide clinical use, mostly in Eastern Europe, for the treatment of more than 50 diseases including cancer, and it was claimed that treatment was successful in more than three million patients [Rojavin and Ziskin, 1998; Teppone and Avakyan, 2010].…”

Section: Introductionmentioning

confidence: 99%

The Lack of Toxic Effect of High‐Power Short‐Pulse 101 GHz Millimeter Waves on Healthy Mice

Furman

Komoshvili

Levitan

et al. 2020

Bioelectromagnetics

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Irradiation of cancer cells by non‐ionizing millimeter waves (MMW) causes increased cell mortality. We examined if MMW have toxic effects on healthy mice. To that end, the skin of healthy C57BL/6 mice was irradiated locally at the right flank with 101 GHz MMW in a pulsed (5–10 µs) regime using a free electron laser. Irradiation was performed in a dose‐dependent manner, with 20–50 pulses and a power range of 0.5–1.5 kW. Physical, physiological, and pathological parameters as well as behavior were examined before and after irradiation. Our results showed that all parameters were within normal range for all experimental mice groups and for the control group. No significant changes were noted in the physical, physiological, or behavioral status of the mice following irradiation as compared with the control group. In addition, no significant changes were found in locomotor, exploratory behavior, or anxiety of the irradiated mice and no pathological changes were noted following the hematological and biochemical blood analysis. Our results indicate that irradiation of healthy mice with MMW does not cause any general toxic effects. Bioelectromagnetics. © 2020 Bioelectromagnetics Society.

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“…MMWs can be used as a monotherapy or in combination with other treatment methods. As an adjunct therapy, they are widely used to protect the immune system from the toxic effects of chemo-and radiation therapy in the treatment of cancer [3,7].…”

Section: Introductionmentioning

confidence: 99%

Millimeter Wave and Drug Induced Modulation of the Immune System -Application in Cancer Immunotherapy

Logani¹,

Bhopale²,

Ziskin³

2012

J Cel Sci Therapy

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Extremely High-Frequency Therapy in Oncology

Abstract: In spite of the fact that not all mechanisms underlying effects of EHF therapy are known as yet, this therapeutic modality has been shown to have great potential in clinical oncology from studies performed in Eastern Europe and Russia.

Cited by 14 publications

References 5 publications

Millimeter wave radiation induces apoptosis via affecting the ratio of Bax/Bcl-2 in SW1353 human chondrosarcoma cells

Millimeter wave radiation induces apoptosis via affecting the ratio of Bax/Bcl-2 in SW1353 human chondrosarcoma cells

The Lack of Toxic Effect of High‐Power Short‐Pulse 101 GHz Millimeter Waves on Healthy Mice

Millimeter Wave and Drug Induced Modulation of the Immune System -Application in Cancer Immunotherapy

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