The Lack of Toxic Effect of High‐Power Short‐Pulse 101 GHz Millimeter Waves on Healthy Mice

Furman, Olga; Komoshvili, K.; Levitan, Jakob; Yahalom, Asher; Marks, H. S.; Borodin, D.; Liberman-Aronov, Stella

doi:10.1002/bem.22247

Cited by 7 publications

(7 citation statements)

References 32 publications

(41 reference statements)

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“…Clinical adaptation of this treatment is limited by the current unavailability of noninvasive devices operating in this bandwidth. Overcoming the low penetration depth of MMW in biological tissue, pulsed irradiation regimes operating within safety limits [44] enables deeper penetration and is a potential approach for further development of devices operating in MMW spectrum. This study demonstrates W-band (75 -105 GHz) MMW irradiation delivering an extended energy dosage over 10 minutes effectively terminates H1299 human lung cancer viability.…”

Section: Resultsmentioning

confidence: 99%

W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-tumorigenic MCF-10A Human Epithelial Cells In Vitro

Komoshvili¹,

Israel²,

Levitan³

et al. 2020

Preprint

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Therapeutically effective treatments of cancer are limited. To calibrate the efficiency of the novel technique we recently discovered to modulate cancer cell viability using tuned electromagnetic fields; H1299 human lung cancer cells were irradiated in a sweeping regime of W-band (75-105 GHz) millimeter waves (MMW) at 0.2 mW/cm2 (2 W/m2). Effects on cell morphology, cell death and senescence were examined and compared to that of non-tumorigenic MCF-10A human epithelial cells. MMW irradiation led to alterations of cell and nucleus morphology of H1299 cells, significantly increasing mortality and senescence over 14 days of observation. Extended irradiation of 10 minutes duration resulted in complete death of exposed H1299 cell population within two days, while healthy MCF-10A cells remained unaffected even after 16 minutes of irradiation under the same conditions. Irradiation effects were observed to be specific to MMW treated H1299 cells and absent in the control group of non-irradiated cells. MMW irradiation did not affect cell morphology of immortalized MCF-10A cells. Irradiation with low intensity MMW shows an antitumor effect on H1299 lung cancer cells. This method provides a novel treatment modality enabling targeted specificity for various types of cancers.

show abstract

Section: Resultsmentioning

confidence: 99%

W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-tumorigenic MCF-10A Human Epithelial Cells In Vitro

Komoshvili¹,

Israel²,

Levitan³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Clinical adaptation of this treatment is limited by the current unavailability of non-invasive devices operating in this bandwidth. Overcoming the low penetration depth of MMW in biological tissue, pulsed irradiation regimes operating within safety limits [46] enables deeper penetration and is a potential approach for further development of devices operating in MMW spectrum. This study demonstrates W-band (75 -105 GHz) MMW irradiation delivering an extended energy dosage over 10 minutes effectively terminates H1299 human lung cancer cell viability.…”

Section: Resultsmentioning

confidence: 99%

W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-tumorigenic MCF-10A Human Epithelial Cells In Vitro

Komoshvili¹,

Israel²,

Levitan³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Therapeutically effective treatments of cancer are limited. To calibrate the efficiency of the novel technique we recently discovered to modulate cancer cell viability using tuned electromagnetic fields; H1299 human lung cancer cells were irradiated in a sweeping regime of W-band (75-105 GHz) millimeter waves (MMW) at 0.2 mW/cm2 (2 W/m2). Effects on cell morphology, cell death and senescence were examined and compared to that of non-tumorigenic MCF-10A human epithelial cells. MMW irradiation led to alterations of cell and nucleus morphology of H1299 cells, significantly increasing mortality and senescence over 14 days of observation. Extended irradiation of 10 minutes duration resulted in complete death of exposed H1299 cell population within two days, while healthy MCF-10A cells remained unaffected even after 16 minutes of irradiation under the same conditions. Irradiation effects were observed to be specific to MMW treated H1299 cells and absent in the control group of non-irradiated cells. MMW irradiation affected nuclear morphology of H1299 cells only and not of the immortalized MCF-10A cells. Irradiation with low intensity MMW shows an antitumor effect on H1299 lung cancer cells. This method provides a novel treatment modality enabling targeted specificity for various types of cancers.

show abstract

“…Clinical adaptation of this treatment is limited by the current unavailability of non-invasive devices operating in this bandwidth. Overcoming the low penetration depth of MMW in biological tissue, pulsed irradiation regimes operating within safety limits [45] enables deeper penetration and is a potential approach for further development of devices operating in MMW spectrum. This study demonstrates W-band (75-105 GHz) MMW irradiation delivering an extended energy dosage over 10 min effectively terminates H1299 human lung cancer cell viability.…”

Section: Discussionmentioning

confidence: 99%

W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro

et al. 2020

Self Cite

View full text Add to dashboard Cite

Therapeutically effective treatments of cancer are limited. To calibrate the efficiency of the novel technique we recently discovered to modulate cancer cell viability using tuned electromagnetic fields; H1299 human lung cancer cells were irradiated in a sweeping regime of W-band (75–105 GHz) millimeter waves (MMW) at 0.2 mW/cm2 (2 W/m2). Effects on cell morphology, cell death and senescence were examined and compared to that of non-tumorigenic MCF-10A human epithelial cells. MMW irradiation led to alterations of cell and nucleus morphology of H1299 cells, significantly increasing mortality and senescence over 14 days of observation. Extended irradiation of 10 min duration resulted in complete death of exposed H1299 cell population within two days, while healthy MCF-10A cells remained unaffected even after 16 min of irradiation under the same conditions. Irradiation effects were observed to be specific to MMW treated H1299 cells and absent in the control group of non-irradiated cells. MMW irradiation affected nuclear morphology of H1299 cells only and not of the immortalized MCF-10A cells. Irradiation with low intensity MMW shows an antitumor effect on H1299 lung cancer cells. This method provides a novel treatment modality enabling targeted specificity for various types of cancers.

show abstract

The Lack of Toxic Effect of High‐Power Short‐Pulse 101 GHz Millimeter Waves on Healthy Mice

Cited by 7 publications

References 32 publications

W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-tumorigenic MCF-10A Human Epithelial Cells In Vitro

W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-tumorigenic MCF-10A Human Epithelial Cells In Vitro

W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-tumorigenic MCF-10A Human Epithelial Cells In Vitro

W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro

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