Extreme anemia (Hb 33 g/L) in a 13-year-old girl: Is the transfusion always mandatory?

Beverina, Ivo; Macellaro, Patrizia; Parola, Luciana; Brando, Bruno

doi:10.1016/j.transci.2018.05.026

Cited by 12 publications

(13 citation statements)

References 15 publications

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“…Though necessitating careful execution with a full understanding of the potential undesired effects [ 43 , 44 ], intravenous iron infusion is an excellent strategy for improving patient quality of life and reducing recourse to allogeneic transfusions. There are numerous articles [ 45 , 46 , 47 , 48 ] in support of the efficacy and safety of treating anemia with intravenous iron infusion. The document issued by Emilia Romagna opens the way for the extensive use of iron infusion in the field.…”

Section: Discussionmentioning

confidence: 99%

Organizational Strategies for the Management of Intravenous Iron Therapy in Non-Hospitalized Settings: A Safe Opportunity to Implement Patient Blood Management in Italy

et al. 2021

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This article analyzes the recommendations issued by the Emilia Romagna region in July 2020 on “Organizational strategies for the safe management of intravenous iron therapy in patients in non-hospitalized settings”. The objective of these recommendations is to set up safe intravenous iron administration sites outside the hospital environment across the national territory. The document facilitates the organization of methods for intravenous iron infusion that are safe for the patient and correct from a medico-legal perspective. In addition, it opens the way for the widespread use of iron infusion in the field, providing benefits to patient quality of life. This program prevents unnecessary transfusions, reduces costs, prevents overcrowding in hospitals in the event of a pandemic, and enables patient treatment in the field, thus, saving on the use of personnel.

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Section: Discussionmentioning

confidence: 99%

Organizational Strategies for the Management of Intravenous Iron Therapy in Non-Hospitalized Settings: A Safe Opportunity to Implement Patient Blood Management in Italy

et al. 2021

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“…On the other hand, there is a noticeable lack of identified guidelines in the area of pediatric care, despite much recent research pointing to the potential role of IV iron in children. [65][66][67] There was also considerable variation by geography, with US guidelines on the whole having fewer that included recommendations around IV iron. The issue of the lack of updating of guidelines means that many of the guidelines are not reflecting the current evidence on the efficacy and safety of IV iron.…”

Section: Discussionmentioning

confidence: 99%

Systematic review of guidelines for the diagnosis and treatment of iron deficiency anemia using intravenous iron across multiple indications

Numan

Kaluza

2020

Current Medical Research and Opinion

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“…As a result, the awareness of the effective role of iron supplementation to treat ID anaemic patients in the preoperative setting is increasing . For example, an increment in haemoglobin concentration of more than 2 g/dl can be accomplished with intravenous iron in severe anaemic ID patients . Transfusion with allogeneic blood products has been the first choice to treat anaemia for many decades.…”

Section: Discussionmentioning

confidence: 99%

Health economics of Patient Blood Management: a cost‐benefit analysis based on a meta‐analysis

et al. 2019

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Background and Objectives Patient Blood Management (PBM) is the timely application of evidence‐based medical and surgical concepts designed to improve haemoglobin concentration, optimize haemostasis and minimize blood loss in an effort to improve patient outcomes. The focus of this cost‐benefit analysis is to analyse the economic benefit of widespread implementation of a multimodal PBM programme. Materials and Methods Based on a recent meta‐analysis including 17 studies (>235 000 patients) comparing PBM with control care and data from the University Hospital Frankfurt, a cost‐benefit analysis was performed. Outcome data were red blood cell (RBC) transfusion rate, number of transfused RBC units, and length of hospital stay (LOS). Costs were considered for the following three PBM interventions as examples: anaemia management including therapy of iron deficiency, use of cell salvage and tranexamic acid. For sensitivity analysis, a Monte Carlo simulation was performed. Results Iron supplementation was applied in 3·1%, cell salvage in 65% and tranexamic acid in 89% of the PBM patients. In total, applying these three PBM interventions costs €129·04 per patient. However, PBM was associated with a reduction in transfusion rate, transfused RBC units per patient, and LOS which yielded to mean savings of €150·64 per patient. Thus, the overall benefit of PBM implementation was €21·60 per patient. In the Monte Carlo simulation, the cost savings on the outcome side exceeded the PBM costs in approximately 2/3 of all repetitions and the total benefit was €1 878 000 in 100·000 simulated patients. Conclusion Resources to implement a multimodal PBM concept optimizing patient care and safety can be cost‐effectively.

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Extreme anemia (Hb 33 g/L) in a 13-year-old girl: Is the transfusion always mandatory?

Cited by 12 publications

References 15 publications

Organizational Strategies for the Management of Intravenous Iron Therapy in Non-Hospitalized Settings: A Safe Opportunity to Implement Patient Blood Management in Italy

Organizational Strategies for the Management of Intravenous Iron Therapy in Non-Hospitalized Settings: A Safe Opportunity to Implement Patient Blood Management in Italy

Systematic review of guidelines for the diagnosis and treatment of iron deficiency anemia using intravenous iron across multiple indications

Health economics of Patient Blood Management: a cost‐benefit analysis based on a meta‐analysis

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