For general polytopes, it has turned out that with respect to many questions it suffices to consider only the simple polytopes, i.e., d-dimensional polytopes where every vertex is contained in only d facets. In this paper, we show that the situation is very different within the class of 0/1-polytopes, since every simple 0/1-polytope is the (cartesian) product of some 0/1-simplices (which proves a conjecture of Ziegler), and thus, the restriction to simple 0/1-polytopes leaves only a very small class of objects with a rather trivial structure.