Extravascular type of intravascular papillary endothelial hyperplasia mimicking parotid gland neoplasia and the possible role of ferritin in the pathogenesis: A case report

Mignogna, Chiara; Barca, Ida; Vito, Anna Di; Puleo, Francesca; Malara, Natalia; Giudice, Amerigo; Giudice, Mario; Barni, Tullio; Donato, Giuseppe; Cristofaro, Maria Giulia

doi:10.3892/mco.2016.1117

Cited by 4 publications

(20 citation statements)

References 25 publications

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“…While histopathological examination is sufficient for diagnosing IPEH, additional immunohistochemical staining may help to facilitate or confirm differential diagnosis. IPEH typically presents as positive for CD31 and CD34, which are the most sensitive markers indicating the vascular origin of the lesion [2,6,9]. In the present case endothelial cells were positive for CD34.…”

Section: Discussionsupporting

confidence: 47%

“…Histopathologic examination is an important component of a definite diagnosis of IPEH. Clinical and radiological characteristics of IPEH are nonspecific and resemble various vascular neoplasms such as angiosarcoma, malignant endovascular papillary angioendothelioma, Kaposi’s sarcoma, and hemangioma, and lymphangioma [2,6,9,15]. The very similar histopathological features of IPEH and angiosarcoma make differential diagnosis difficult [6].…”

Section: Discussionmentioning

confidence: 99%

“…It is more common in women, and can occur at any age [6,8]. The associated clinical manifestations and radiology findings are nonspecific, and diagnosis is based on histopathology analysis [5,9].…”

Section: Introductionmentioning

confidence: 99%

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Intravascular Papillary Endothelial Hyperplasia of the Vocal Cord: A Case Report and Review of the Literature

Shim

Kim

2019

Am J Case Rep

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Objective: Rare disease Background: Intravascular papillary endothelial hyperplasia (IPEH), is a vascular tumor characterized by the proliferation of endothelial cells with papillary formations. It is a rare benign disease; therefore, it is important to exclude malignant vascular neoplasm in order to prevent misdiagnosis and inappropriate overtreatment. Case Report: Herein, we describe the case of a 51-year-old male who reported changes in his voice, and who was preoperatively diagnosed with vocal cord polyp and hemorrhagic change based on laryngoscopy. He underwent laryngomicrosurgery and the lesion was completely excised via the microflap surgical method. Histopathology analysis was consistent with IPEH. Conclusions: Herein, we report an extremely rare case of IPEH arising from the true vocal cord, and we provide a brief review of the relevant literature and a detailed discussion of this rare clinical entity.

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

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Intravascular Papillary Endothelial Hyperplasia of the Vocal Cord: A Case Report and Review of the Literature

Shim

Kim

2019

Am J Case Rep

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“…The median age was 34.79 (range 0-70). We found 9 MT cases in the head and skull base, 16,18,[31][32][33]35,40,43 6 in the orbit,-3,14,20,26,29,37 7 cases in paranasal sinuses, 8,9,17,25,28,44,46 1 case within the parotid gland, 41 2 in parapharyngeal space, 19,22 2 in larynx and hypopharynx; 27,39 4 in buccal space or cheek, 23,24,34,36 1 in submandibular space, 42 1 in the lip, 30 1 in the mandible, 38 3 in the neck. 15,21,45 CT examination was reported in 27 out of 36 articles and in 28 patients, but CT findings were described in 23 articles.…”

Section: Dovepressmentioning

confidence: 80%

CT and MRI Findings of Head and Neck Masson’s Tumor: A Rare Case Report and Systematic Review of the Literature

Giannitto¹,

Mercante²,

Spriano³

et al. 2021

RMI

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Background: Masson's tumor (MT) is a rare benign vascular disease. In literature, detailed description of its radiological findings is not available and functional imaging such as diffusion weighted (DW)-MRI has never been described. We aim to summarize the CT and MRI findings in our representative case and to conduct a systematic review of the literature. Case Presentation: We reported a 54-year-old ex-smoker male patient who presented with a nodular mass to the left cheek. He denied any previous trauma. CT examination performed on initial presentation revealed a well circumscribed solid oval mass with soft tissue density, a calcified focus and no significative contrast enhancement after contrast administration. MRI showed a well circumscribed solid oval mass, with intermediate T2 signal intensity with areas of high T2 signal intensity and the presence of peripheral high-flow serpentine vessels, low T1 signal intensity. The mass showed a non-enhancing area with enhancing vessels after intravenous contrast administration. We surveyed CT and MRI findings of head and neck MT of English and French language papers, published from 1981 to 2019, together with our representative case. We included articles with a description of CT and/or MRI findings of head and neck MT. Conclusion:We have experienced one case and have evaluated imaging findings through systematic review. Only 36 articles were eligible. CT and MRI findings were reported in 27 and 23 articles, respectively. To date, no diffusion weighted imaging (DWI)-MRI findings have been described. The most frequent findings in CT were a well-defined mass with high or soft tissue density. The most frequent MRI findings were a non-homogeneous signal intensity in T1 and T2 weighted sequences, with foci of hyperintensity, multiple septations or flow voids. After contrast administration, the enhancement could be homogeneous, non-homogeneous, nodular or peripheral. In our case, we found a non-homogeneous hyperintensity in DWI-MRI with an area of restricted diffusion and low apparent diffusion coefficient (ADC) was observed (0.963 × 10 −3 mm 2 /s +\-0.12 SD). The imaging characteristics cannot provide a pre-operative identikit of MT and surgical removal is necessary to accurately differentiate it from malignant angiosarcoma but radiological evaluation is useful in surgical planning.

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“…3 Cases of various affected sites of the head and neck region, for instance, oral mucosa, lips, tongue, gingiva, skin of the scalp and face, and orbit have been reported. 10 The presentation of IPEH in the salivary gland is relatively rare, with a majority in the parotid gland. 1,7,10 On reviewing the accessible literature on Masson's tumors of salivary gland, only 4 cases were reported to date (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Intravascular Papillary Endothelial Hyperplasia (Masson’s Tumor) of the Submandibular Gland: A Case Report

2021

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Intravascular papillary endothelial hyperplasia (IPEH), a rare benign endothelial vascular lesion related to thrombosis, generally develops in fingers, trunk, head, and neck. Nevertheless, it has been rarely reported in the salivary gland. In this article, we report a case of IPEH of the right submandibular gland in a 37-year-old female whose initial impression was sialadenitis secondary to sialolithiasis. To date, our case may be the first well-documented report of IPEH in the submandibular gland. The patient underwent ablation of the submandibular gland, and no evidence of recurrence was found during follow-up.

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Extravascular type of intravascular papillary endothelial hyperplasia mimicking parotid gland neoplasia and the possible role of ferritin in the pathogenesis: A case report

Cited by 4 publications

References 25 publications

Intravascular Papillary Endothelial Hyperplasia of the Vocal Cord: A Case Report and Review of the Literature

Intravascular Papillary Endothelial Hyperplasia of the Vocal Cord: A Case Report and Review of the Literature

CT and MRI Findings of Head and Neck Masson’s Tumor: A Rare Case Report and Systematic Review of the Literature

Intravascular Papillary Endothelial Hyperplasia (Masson’s Tumor) of the Submandibular Gland: A Case Report

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