Extraskeletal osteogenic sarcoma.A Late Complication of Radiation Therapy

Extraosseous sarcoma

“…Such as radiation [4,6,24], articular implantation [17], previously benign lesions [13] and trauma [10].…”

Skin tumour incidence in CBA mice given fractionated exposures to low energy beta particles.

“…It was impossible to tell whether this metastatic osteogenic tumour had started de novo as an osteosarcoma of extraskeletal soft tissue (Fine and Stout, 1956) or whether it arose as a malignant change in a patch of ossification in the irradiated dermis. Osteosarcoma of soft tissue can follow irradiation in man but is exceedingly rare (Boyer and Navin, 1965).…”

Radiation-induced neoplasms following curative therapy for retinoblastoma

“…T h e remaining tumors appeared following latent periods of 16 to 30 years. T o determine whether the very young age of patients with retinoblastoma at the time of radiotherapy (mean = 1.33 years) had effected the length of the latent interval, series of tumors induced by radiotherapy in adults were tabulated for comparison (1,2,5,7,11,14). Cases involving occupational exposure (radiologists, dentists and X-ray technicians) were excluded since time-dose relationships were not comparable.…”