Skin tumour incidence in CBA mice given fractionated exposures to low energy beta particles.

Tumour Incidence and Longevity in Neutron and Gamma-irradiated Rabbits, with an Assessment of R.b.e.

“…These degenerative conditions are distinguishable from the dental malocclusion and overgrowth reported in young rabbits (Pollock 1951, Ireson 1968, Zeman and Fielder 1969 . Infection resulted and three rabbits had dental abscesses and one an abscess of the cheek with pyaemic abscesses of the liver .…”

“…Radiation-induced fibrosarcomas are relatively uncommon in man but have been reported after radiotherapy (Jones 1953, Gane, Lindup, Strickland and Bennet 1970, Travis, Kreuther, Young and Gerald 1976, The, Qasim and Talermen 1976 . The lowest exposure to be incriminated was 1200 R of 140 kV X-rays (Rao 1964) but the lesion for which radiotherapy was given was not examined histologically and the sarcoma could have been a recurrence of the original tumour .…”

“…Radiation-induced basal-cell tumours of the skin have not been seen in mice (Hulse 1967, Hulse and Mole 1969, Albert, Burns and Bennet 1972 but they do occur and have been extensively studied in rats (Henshaw, Snider and Riley 1949, Albert, Phillips, Bennet, Burns and Heimbach 1969, Albert et al . 1972 .…”

Radiation-Induced Hair-Follicle Damage and Tumor Formation in Mouse and Rat Skin<xref ref-type="fn" rid="FN2">2</xref>

“…It appeared to us that further insight into the matter might be obtained by comparing the radiation tumor and hair follicle injury response of the rat and mouse. Reports from other laboratories indicate that the mouse has a very different skin tumor response pattern than the rat; relatively few tumors can be produced by ionizing radiation, and the majority of the epithelial tumors are epidermoid carcinomas rather than adnexal tumors as in the rat (9,10). We therefore undertook the experiment reported here.…”