Extrapyramidal signs occurring after sympathetic block for complex regional pain syndrome responding to diphenhydramine

Abstract

Supplemental Digital Content is available in the text

Chlorphenamine for prolonged drug‐induced extrapyramidal side effects in a dog

“…Instead, administration of an anticholinergic agent, benztropine, trihexyphenidyl or diphenhydramine, may relieve dystonia within minutes in people 3. Acute EPS after propofol administration was recently reported in a 17‐year‐old boy 17.…”

“…Clinical signs observed in people with EPS include dystonia,8 9 akathisia,10 11 parkinsonism, tremors, rigidity12 and dyskinesia 13. EPS typically resolve spontaneously or improve with pharmacological interventions 3. Acute reactions are often transient, but late‐onset and persistent signs, up to years, have been described in individuals 3…”

“…EPS typically resolve spontaneously or improve with pharmacological interventions 3. Acute reactions are often transient, but late‐onset and persistent signs, up to years, have been described in individuals 3…”

“…Drug‐induced extrapyramidal side effects (EPS), also named drug‐induced movement disorders, are commonly reported in people 1. EPS have been associated with administration of dopamine receptor blocking agents, antipsychotic drugs, anaesthetics, opioids, antiemetics and sedatives, including phenothiazine derivatives, in toxic and standard doses, in people and animals 1–7…”

“…1 EPS have been associated with administration of dopamine receptor blocking agents, antipsychotic drugs, anaesthetics, opioids, antiemetics and sedatives, including phenothiazine derivatives, in toxic and standard doses, in people and animals. [1][2][3][4][5][6][7] Clinical signs observed in people with EPS include dystonia, 8 9 akathisia, 10 11 parkinsonism, tremors, rigidity 12 and dyskinesia. 13 EPS typically resolve spontaneously or improve with pharmacological interventions.…”