Extrapyramidal Reactions to Ondansetron: Cross-Reactivity Between Ondansetron and Prochlorperazine?

Šprung, Juraj; Choudhry, Faisal M; Hall, Brian A.

doi:10.1213/01.ane.0000058845.72102.f2

Cited by 27 publications

(24 citation statements)

References 15 publications

(13 reference statements)

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“…1,2 However, our patient followed commands and responded to all questions immediately upon emerging from anesthesia which was in contrast to our previous experience. 1,2 While there are some similarities between previously reported cases, the present case is unique in that the long lasting carpopedal spasm dominated with presentation. At the same time, the common characteristics with our previously reported cases 1,2 included the observations that EPS delayed the patient's discharge, incurred significant cost for an extensive neurological evaluation, and all symptoms and signs of EPS resolved without consequence within the first day.…”

Section: Ondansetron and Carpopedal Spasmsupporting

confidence: 69%

“…However, ondansetron-associated EPS have been reported on several occasions. 1,2 We describe an unusual presentation of ondansetron-induced EPS characterized by carpopedal spasm.…”

Section: Ondansetron and Carpopedal Spasmmentioning

confidence: 98%

“…[1][2][3] Our experience with the GlideScope® includes 120 patients to date. In 25 cases, there was some difficulty in directing the endotracheal tube (ETT) into the larynx despite a good view of the larynx on the video screen.…”

Section: A Maneuver To Facilitate Endotracheal Intubation Using the Gmentioning

confidence: 99%

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Ondansetron and carpopedal spasm

Ramakrishna

Trentman

Hall³

et al. 2008

Can J Anesth/J Can Anesth

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Section: Ondansetron and Carpopedal Spasmsupporting

confidence: 69%

“…However, ondansetron-associated EPS have been reported on several occasions. 1,2 We describe an unusual presentation of ondansetron-induced EPS characterized by carpopedal spasm.…”

Section: Ondansetron and Carpopedal Spasmmentioning

confidence: 98%

See 1 more Smart Citation

Ondansetron and carpopedal spasm

Ramakrishna

Trentman

Hall³

et al. 2008

Can J Anesth/J Can Anesth

Self Cite

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“…The efficacy of antiemetic drugs is limited and their administration is not free from side effects [7] [8]. No isolated intervention can completely prevent or treat PONV.…”

Section: Introductionmentioning

confidence: 99%

A Randomized Controlled Trial Comparing the Efficacy of P6 Acupuncture Plus Ondansetron versus Ondansetron or P6 Acupuncture in the Prevention of Nausea and Vomiting after Bupivacaine-Morphine Spinal Anesthesia

Yin¹,

Bráz²,

Colares³

et al. 2017

OJAnes

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Objective: To compare P6 acupuncture plus ondansetron with either ondansetron or P6 acupuncture in the prevention of postoperative nausea and vomiting (PONV) in patients submitted to spinal anesthesia. Methods: A randomized controlled trial was performed with 90 patients undergoing orthopedic surgery under spinal anesthesia with bupivacaine, 15 to 17.5 mg, and morphine, 100 μg. They were assigned to one of the three groups: Group Ondansetron (n = 30), patients were given ondansetron, 8 mg intravenously, before spinal block was performed; Group P6 acupuncture (n = 30), patients were subjected to bilateral electrical stimulation of P6 acupoint for 30 minutes before anesthesia; and Group P6 acupuncture plus ondansetron (n = 30), the exact combination of the groups Ondansetron and P6 acupuncture. Results: In the post anesthesia care unit, the incidence of nausea and vomiting ranged from 13.3% to 26.7% and from 6.7% to 13.3%, respectively, with no significant differences among groups (p > 0.05). Ondansetron group had the highest incidence of nausea (73.3%) (p < 0.001) and vomiting (43.3%) (p < 0.001) at the ward from 0 to 24 hours, followed by P6 acupuncture (33.3% and 26.7%) and P6 acupuncture plus ondansetron groups (16.0% and 0%). Conclusion: Preoperative stimulation of P6 acupoint in combination with ondansetron has higher efficacy than either P6 acupoint stimulation or the administration of

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“…Pharmacological prophylaxis does not eliminate the incidence of PONV completely and can increase the costs and the risk of adverse events [2]. Supplemental oxygen may be an additional simple method in multimodal PONV prophylaxis.…”

Section: Introductionmentioning

confidence: 99%

Effects of high intraoperative inspired oxygen on postoperative nausea and vomiting in gynecologic laparoscopic surgery

Šimurina

Mraović

Mikulandra

et al. 2010

Journal of Clinical Anesthesia

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Extrapyramidal Reactions to Ondansetron: Cross-Reactivity Between Ondansetron and Prochlorperazine?

Abstract: Ondansetron can rarely induce extrapyramidal reactions in susceptible individuals. Our patient had a history of drug-induced dystonic reaction; therefore, these patients may be susceptible to extrapyramidal adverse reactions after ondansetron.

Cited by 27 publications

References 15 publications

Ondansetron and carpopedal spasm

Ondansetron and carpopedal spasm

A Randomized Controlled Trial Comparing the Efficacy of P6 Acupuncture Plus Ondansetron versus Ondansetron or P6 Acupuncture in the Prevention of Nausea and Vomiting after Bupivacaine-Morphine Spinal Anesthesia

Effects of high intraoperative inspired oxygen on postoperative nausea and vomiting in gynecologic laparoscopic surgery

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