Extraosseous osteogenic sarcoma.Clinicopathological study of eight cases and review of literature

Abstract

Since 1963, eight patients with extraosseous osteogenic sarcoma were treated at Roswell Park Memorial Institute; these constituted 4.6% of all the osteogenic sarcoma patients during the period. The mean age of the patients was 58.7 years and a ratio of male to female was equal. Local swelling of insidious onset was the commonest symptom. All the tumors originated in extremities; the lower extremity was the more frequent site. At the time of diagnosis, seven patients had localized tumor and one had pulmonary metastases. Radiologically, a soft tissue mass with spotty calcification without any adjacent bone involvement, was the classical sign. Elevated alkaline phosphatase without liver metastases was observed in five of six patients when disease progressed. Ultrastructurally, the prominent cell type was a fibroblast-like cell intermingled with varying numbers of osteoblasts and undifferentiated mesenchymal cells. Extreme morphologic variability probably accounts for the difference in composition of this tumor. Radical soft part excision or amputation should be the treatment of choice. Local recurrence was not seen in four patients after radical surgery, but it was observed in three of the four patients who had simple excision. The lung was the commonest site of metastases. No objective responses were observed after chemo-or immunotherapy. The overall median survival was 20 months and 5-year survival rate was 25%.

Osteosarcoma in a Phthisical Feline Eye

“…Intraocular bone formation also has been described in association with several specific structural abnormalities of the eye, including buphthalmos and microphthalmos, and with several benign ocular neoplasms, including angiomata, dermolipomata, and teratomata [7,21]. Isolated episcleral or choroidal deposits of bone (episcleral or choroidal osseous choristomata) also have been described in otherwise normal eyes [3,14].…”

“…Nevertheless, lesions at other relatively common primary sites of feline osteosarcoma (including the facial bones and axial skeleton) are difficult to exclude by physical examination alone [13]. Furthermore, extraosseous osteogenic sarcoma is a well-established entity in man [21], and has been described in the dog as well [4].…”

Epithelial-mesenchymal transition in osteogenic sarcoma of the neck following oral squamous cell carcinoma

“…Extraosseous osteogenic sarcomas (EOSs) occur rarely, accounting for 1% of all soft tissue sarcomas and 4% of all osteogenic sarcomas [1][2][3] . EOSs are biologically highly malignant neoplasm with an average 5-year survival rate of 15.6%.…”

Primary Osteogenic Sarcoma of the Kidney:A Case Report and Review of the Literature

“…Elevated serum alkaline phosphatase, in the absence of liver and bone disease may be noted (1 I , 17, 22, 24) and is thought to be indicative of hyperactive bone metabolism. Alkaline phosphatase seems to be important in the follow-up of patients with extraossseous osteogenic sarcomas as a potential tumor marker, monitoring response to treatment (25). Radiotherapy has not been associated with the cause of any of the reported cases.…”

“…The original description of the disease by Haingin & Poole (1) was based entirely on autopsy evidence and since then only 25 cases have been reported in the international literature . Extraskeletal osteogenic sarcomas are uncommon tumors and can originate either from soft tissues or from parenchymatous organs such as the lung, breast or kidney (25). They represent approximately 4% of all osteogenic sarcomas and are frequently located on the proximal lower extremities and buttocks and their onset has been associated with radiation or trauma (26).…”