Extranodal natural killer/T cell lymphomas with extranasal disease in non-endemic regions are disseminated or have nasal primary: a study of 84 cases from India

Shet, Tanuja; Suryawanshi, Pallavi; Epari, Sridhar; Sengar, Manju; Rangarajan, Venkatesh; Menon, Hari; Laskar, Siddharatha

doi:10.3109/10428194.2014.894188

Cited by 22 publications

(15 citation statements)

References 37 publications

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“…However CD3 negative cases have been previously reported. [7] In this present series all cases were positive for CD56 and CD3 except one patient in whom CD3 was negative. EBER was positive in all cases wherever available.…”

Section: Toxicitysupporting

confidence: 51%

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NK/T Cell Lymphoma: A Tertiary Centre Experience

Arora

Mehta

Ravichandran

et al. 2016

Indian J Hematol Blood Transfus

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Extranodal NK/T-cell lymphoma (ENKTL), nasal type, is a rare type of non-Hodgkin lymphoma that is commonly seen in East Asian countries and is associated with Epstein-Barr virus infection. This is a retrospective study where we describe nine cases of ENKTL; nasal type diagnosed and treated at our center over a period of 2 years. These cases were analyzed retrospectively for clinical presentation (age, sex, site of involvement), immunophenotype, treatment, response and toxicity profile. Sino-nasal symptoms (blocked nose, headache, epistaxis, regurgitation) were the most common presenting complaints (n = 8). Almost 67 % (n = 6/9) of the cases were referred from Bhutan. Necrosis and angiocentricity were the commonest histological features. Depending on the stage of the disease patient were initially treated with chemotherapy (SMILE/CHOP) and Radiotherapy (IFRT). We describe our experience of management of ENKTL, where we observe that Bhutan could be endemic region for this rare tumour.

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Section: Toxicitysupporting

confidence: 51%

“…Of the only 2 large series comprising of 37 cases and 84 cases of ENKTCL described from India, only one study has actually documented the ethnicity of the patients with these neoplasms. Almost half of the cases in that study were from western India where as East India (West Bengal/Assam) constituted 20 % of the overall ENKTCL [7,8].…”

Section: Toxicitymentioning

confidence: 86%

NK/T Cell Lymphoma: A Tertiary Centre Experience

Arora

Mehta

Ravichandran

et al. 2016

Indian J Hematol Blood Transfus

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“…Lymph node involvement may be seen in ENKTL . Shet et al identified lymph nodes as the primary site in nine of 84 (11%) ENKTL cases analysed by them, which highlights the need for documenting cytological features of ENKTL, as nodal masses are an easily accessible site to perform FNAC.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of cytomorphological features of extranodal NK/T‐cell lymphoma, nasal type

et al. 2019

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Objective: Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is an aggressive extranodal lymphoma of NK-cell or T-cell lineage. Its clinical features overlap with those of several sinonasal mass lesions. While the histopathological features are well described, diagnosis is often difficult, owing to presence of extensive coagulative necrosis, so that repeated biopsies may sometimes be necessary for correct diagnosis. Literature on cytological findings of ENKTL is limited. Methods: Cytomorphological features of cases of histologically confirmed ENKTLhaving corresponding cytology samples were reviewed retrospectively, to identify distinctive features that could possibly suggest this entity. Results:Aspirates from five patients were studied: four from cervical nodes, one from cheek swelling and one from pleural fluid. Two aspirates were reported as positive for malignancy, two as atypical lymphoid proliferation and one was non-diagnostic. Pleural fluid was reported as malignant, favouring a diagnosis of carcinoma. On cytology, aspirates showed medium to large cells with folded, indented nuclei and abundant pale cytoplasm, some with tongue-like cytoplasmic protrusions. A distinctive feature was presence of large loose clusters of tumour cells with arborising capillaries running through them. Interestingly, necrosis was consistently absent.Subsequent biopsies from palate (three cases) and nasal masses (two cases) confirmed the diagnosis of ENKTL.Conclusions: Suspicion of ENKTL on cytology is crucial for timely diagnosis to avoid diagnostic delay, especially when only highly necrotic biopsy samples are available.Awareness of distinctive cytomorphological features is required to make fine needle aspiration an effective diagnostic tool for initial diagnosis and for evaluation of possible recurrences. K E Y W O R D Saspiration cytology, fluid cytology, haematolymphoid, NK/T-cell lymphoma, sinonasal

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“…Tumors of the T lineage are very rare and are mainly represented by the involvement of the eye socket by an extranodal nasal type [18] NK/T-cell lymphoma. In our case series, lymphomas presented themselves as slow-growing, low-density masses causing diplopia and pain.…”

Section: Discussionmentioning

confidence: 99%

The Role of Fine Needle Aspiration of Orbital Lesions: A Case Series

Pagni¹,

Jaconi²,

Smith³

et al. 2016

Acta Cytologica

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Objective: This paper analyzes a series of ultrasound (US)-guided orbital fine needle aspirations (FNAs) which provide diagnostic information that cytopathologists approaching orbital lesions for the first time can find useful and underlines the importance of teamwork. Study Design: The investigators retrospectively obtained data from 24 consecutive orbital FNAs. For all patients, a complete clinicoradiological database was created. FNAs were performed under US guidance with 25-gauge needles and an aspiration biopsy syringe gun, and sent to the Department of Pathology for examination and data management. Results: The mean age of the patients was 54 years. Imaging studies included US, magnetic resonance imaging and computed tomography scans; 9 lesions involved the right orbit and 15 the left orbit. The mean lesion size was 23.6 ± 7.2 mm. After microscopic examination, 7 smears were labeled as ‘nondiagnostic', while in 17 cases a definitive diagnosis was proposed, which always proved to be correct (70.8%, specificity = 100%). Conclusions: The investigators believe that FNA biopsy of orbital masses is a necessary step; its weaknesses lie in the particularly delicate site of sampling and the extreme heterogeneity of lesions. Nevertheless, when orbital FNA is performed within a well-coordinated multidisciplinary team, it is a powerful tool that can be used to define the most appropriate management of these patients.

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Extranodal natural killer/T cell lymphomas with extranasal disease in non-endemic regions are disseminated or have nasal primary: a study of 84 cases from India

Cited by 22 publications

References 37 publications

NK/T Cell Lymphoma: A Tertiary Centre Experience

NK/T Cell Lymphoma: A Tertiary Centre Experience

Spectrum of cytomorphological features of extranodal NK/T‐cell lymphoma, nasal type

The Role of Fine Needle Aspiration of Orbital Lesions: A Case Series

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