Extranodal manifestation of Rosai-Dorfman disease in the breast tissue

Abstract

A 71-year-old asymptomatic female with a history of breast cancer status after right total mastectomy had interval development of several new nodules in the left breast in a 1-year time span. Stereotactic biopsy was performed, which revealed multifocal Rosai Dorfman disease in the left breast. The patient was referred to hematology, and computed tomography of the chest/abdomen/pelvis did not demonstrate any lymphadenopathy elsewhere in the body. This case report discusses incidences of extranodal Rosai Dorfman disease and the differential for breast lesions that can present the same way.

Breast‐related extranodal Rosai‐Dorfman disease presenting as subcutaneous masses with thick hyperechoic rim, with review of the literature

“…Both lesions were also located in the subcutaneous layer rather than in the breast parenchymal tissue, which suggests a dermal origin of the lesions. These radiologic observations have rarely been reported but were present upon review of the radiologic images of several case reports 2–7 . The superficial and dermal locations, as opposed to originating from the fibroglandular tissues, are also consistent with RDD having a predilection for the skin which is the most common extranodal site of manifestation 1,8 .…”

Imaging Findings of Progressing Rosai–Dorfman Disease of the Breast: a Case Report and Literature Review

“…5 Cases with sonographic features mimicking cyst and fibroadenoma have been described as well. 9 Mammographic and sonographic findings of RDD of the breast are usually indistinguishable from those of malignant lesions. They are usually classified as BI-RADS category 4 or 5 and warrant tissue diagnosis.…”

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“…The RDD lesion demonstrates positivity of S100 and CD68, negativity of CD1a by immunohistochemical study. Current common treatment modality is surgical resection with rare recurrence [31][32][33][34][35].…”