Extranodal Lymphomas of the Head and Neck: A 20-Year Experience

Hanna, Ehab Y.; Wanamaker, John R.; Adelstein, David J.; Tubbs, Raymond; Lavertu, Pierre

doi:10.1001/archotol.1997.01900120068011

Cited by 116 publications

(119 citation statements)

References 20 publications

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“…The SG is the anatomic site of 6-26 % of extranodal NHL in the head and neck (H&N), with Taiwan having the lowest incidence, and Iran reporting the highest incidence [20,[23][24][25][26]. Within the limited literature, there is some variability in the reported histological distribution of primary SG lymphomas (Table 3), but on the whole, low grade B-cell lymphomas predominate [10-13, 27, 28].…”

Section: Discussionmentioning

confidence: 99%

Salivary Gland Lymphoproliferative Disorders: A Canadian Tertiary Center Experience

Paliga

Farmer

Bence‐Bruckler

et al. 2013

Head and Neck Pathol

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Salivary gland lymphoproliferative disorders (SGLD) are very rare tumors and clinicopathological data is sparse. In a Canadian series of 30 cases, extracted from the surgical pathology files of The Ottawa Hospital between 1990 and 2010, a clinical, histopathological, and immunophenotypic analysis was conducted. Tumors were staged using the Ann Arbor staging and classified using the World Health Organization 2008 classification. There were 15 salivary gland (SG) primary lymphomas with localized disease, predominantly mucosa associated lymphoid tissue type marginal zone lymphoma (MALT-L), but with a significant incidence of low grade follicular lymphoma (FL) and diffuse large B cell phenotype as well. There were 7 systemic SG lymphomas and 5 patients were diagnosed with lymphoproliferative disorders originating from intraparotid lymph nodes. Finally, the remaining 3 cases represented reactive sialadenitis. A literature review was conducted and our primary lymphoma group was compared to those from other countries. SGLDs are predominantly B cell lymphomas that develop in older adults. Primary tumors, which have MALT-L and low grade FL characteristics, have a favorable survival, however MALT-L have a high rate of relapse. A minority of SG lesions are excised secondary to lymphomas that definitely arose from intraparotid lymph nodes.

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Section: Discussionmentioning

confidence: 99%

Salivary Gland Lymphoproliferative Disorders: A Canadian Tertiary Center Experience

Paliga

Farmer

Bence‐Bruckler

et al. 2013

Head and Neck Pathol

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“…Head and neck lymphomas represent 2-3% of all regional malignant tumors, the second most common neoplasms after SCC [3]. Regional lymph node presentation occurs in 90% of head and neck lymphoma cases, the remainder involving extranodal sites such as Waldeyer's ring [6], with palatine tonsils accounting for more than a third of these cases [7]. Although almost all types of lymphoma of Waldeyer's ring have been reported [8,9], CLL/SLL with tonsillar involvement is a relatively rare occurrence [10], but is likely under-recognized.…”

Section: Discussionmentioning

confidence: 99%

Small Lymphocytic Lymphoma Obscuring Microscopic Tonsillar Squamous Cell Carcinoma: an Unknown Occurrence with a Known Primary

Minca

Popat

Chadha³

et al. 2010

Head and Neck Pathol

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Head and neck squamous cell carcinoma (HNSCC) often presents with cervical lymph node metastases and at times the primary tumor cannot be identified despite extensive workup. Lymphoma is the second most common neoplasm in the head and neck region but is seldom synchronous with HNSCC and rarely involves regional mucosal sites. We report herein a rare occurrence of tonsillar involvement by small lymphocytic lymphoma (SLL) incidentally detected during the workup for a cervical lymph node SCC metastasis of a 52-year-old nonsmoker male. The microscopic human papillomaviruspositive SCC involving the tonsillar surface and crypts was obscured by SLL leading to the initial designation of 'unknown primary'. The occult HNSCC are likely explained by small tumor size, quality and quantity of sampling, thoroughness of endoscopic, radiological and pathological assessment or a combination of the above. The coexistence of another tumor such as lymphoma has not yet been reported as a confounding factor in the workup for cervical SCC metastasis. Since oropharyngeal SCC can be very small and Waldeyer's ring is a common site for lymphoma involvement, identification of such rare collision tumors requires pathologists' awareness, extensive sampling and occasionally ancillary studies for the accurate diagnosis and staging essential for the correct management.

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“…Hanna et al descrevem acometimento de linfonodos associados em 20% dos casos. 1 Em seu trabalho sobre LNH da tonsila, Alvie et al descrevem a adenopatia cervical como um dos sinais iniciais mais comuns nos pacientes com LNH e que somente 10% destes pacientes terão doença extranodal de cabeça e pescoço. 9 Nos casos descritos encontramos como importante sintoma que motivou a procura ao médico a odinofagia e/ou disfagia, mostrando a relevância dos sintomas locais, mesmo nos casos com adenomegalia cervical.…”

Section: Discussão E Comentáriosunclassified

“…De forma semelhante, vemos na literatura que a maior parte dos pacientes com linfoma de tonsila palatina apresentavam disfagia e odinofagia, além de alguns casos de dispnéia, pelo tamanho do tumor. [9][10][11] Hanna et al 1 descrevem os linfomas de tonsila com apresentações de aumento tonsilar unilateral, ulceração, disfagia ou odinofagia, como encontramos em nossos casos.…”

Section: Discussão E Comentáriosunclassified

See 1 more Smart Citation

Linfoma não-Hodgkin envolvendo tonsila palatina: relato de 3 casos

Pinto

Faria

Gomes

et al. 2004

Rev. Bras. Otorrinolaringol.

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O objetivo deste trabalho consiste em relatar três casos de linfoma não-Hodgkin (LNH) com acometimento de tonsilas palatinas acompanhados no Hospital Universitário Clementino Fraga Filho (HUCFF) da Universidade Federal do Rio de Janeiro (UFRJ), com pequena revisão de literatura. Os LNH acometem sítios extra-nodais em 25-30% dos casos. Dos casos extranodais, 10-30% acometem cabeça e pescoço. Destes casos de LNH em cabeça e pescoço, 60-70% estão presentes no anel de Waldeyer, e deste grupo, algumas séries relatam que 80% encontram-se na tonsila palatina. Concluímos, portanto, que o acometimento das tonsilas pelo LNH constitui uma apresentação incomum desta malignidade hematológica, que merece atenção e destaque para que seja feito diagnóstico precoce, seguido de tratamento e acompanhamento corretos.

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Extranodal Lymphomas of the Head and Neck: A 20-Year Experience

Cited by 116 publications

References 20 publications

Salivary Gland Lymphoproliferative Disorders: A Canadian Tertiary Center Experience

Salivary Gland Lymphoproliferative Disorders: A Canadian Tertiary Center Experience

Small Lymphocytic Lymphoma Obscuring Microscopic Tonsillar Squamous Cell Carcinoma: an Unknown Occurrence with a Known Primary

Linfoma não-Hodgkin envolvendo tonsila palatina: relato de 3 casos

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