Salivary Gland Lymphoproliferative Disorders: A Canadian Tertiary Center Experience

Paliga, Aleksandra; Farmer, James; Bence‐Bruckler, Isabelle; Lamba, Manisha

doi:10.1007/s12105-013-0468-6

Cited by 14 publications

(7 citation statements)

References 30 publications

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“…Although no residual MALT lymphoma component was present in this case, the possibility of a high-grade transformation of thymic MALT lymphoma has been reported previously [ 8 ]. Primary salivary gland high-grade B-cell lymphomas occurring with or without a preceding MALT lymphoma have also been observed in Sjögren syndrome [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases

Porubský

Popović

Badve

et al. 2021

Cancers

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Thymic hyperplasia (TH) with lymphoepithelial sialadenitis (LESA)-like features (LESA-like TH) has been described as a tumor-like, benign proliferation of thymic epithelial cells and lymphoid follicles. We aimed to determine the frequency of lymphoma and autoimmunity in LESA-like TH and performed retrospective analysis of cases with LESA-like TH and/or thymic MALT-lymphoma. Among 36 patients (21 males) with LESA-like TH (age 52 years, 32–80; lesion diameter 7.0 cm, 1–14.5; median, range), five (14%) showed associated lymphomas, including four (11%) thymic MALT lymphomas and one (3%) diffuse large B-cell lymphoma. One additional case showed a clonal B-cell-receptor rearrangement without evidence of lymphoma. Twelve (33%) patients (7 women) suffered from partially overlapping autoimmune diseases: systemic lupus erythematosus (n = 4, 11%), rheumatoid arthritis (n = 3, 8%), myasthenia gravis (n = 2, 6%), asthma (n = 2, 6%), scleroderma, Sjögren syndrome, pure red cell aplasia, Grave’s disease and anti-IgLON5 syndrome (each n = 1, 3%). Among 11 primary thymic MALT lymphomas, remnants of LESA-like TH were found in two cases (18%). In summary, LESA-like TH shows a striking association with autoimmunity and predisposes to lymphomas. Thus, a hematologic and rheumatologic workup should become standard in patients diagnosed with LESA-like TH. Radiologists and clinicians should be aware of LESA-like TH as a differential diagnosis for mediastinal mass lesions in patients with autoimmune diseases.

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Section: Discussionmentioning

confidence: 99%

Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases

Porubský

Popović

Badve

et al. 2021

Cancers

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“…It has been described that MALT lymphomas are the most common type among primary SGLs, 8-13 but some studies have shown that FL is as common as MALT lymphoma in the salivary gland. 14,15 Paliga et al reported that out of 15 primary SGL cases, 5 were FLs (33%) and 6 were MALT lymphomas (40%). 15 In Japan, Kojima et al and Nakamura et al indicated the relatively high frequency of FL, being 30% 19 and 22%, 9 respectively, among SGL.…”

Section: Discussionmentioning

confidence: 99%

“…14,15 Paliga et al reported that out of 15 primary SGL cases, 5 were FLs (33%) and 6 were MALT lymphomas (40%). 15 In Japan, Kojima et al and Nakamura et al indicated the relatively high frequency of FL, being 30% 19 and 22%, 9 respectively, among SGL. In our study, FL was also as common as MALT lymphoma among primary SGLs.…”

Section: Discussionmentioning

confidence: 99%

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Immunohistochemical Reappraisal Regarding the Frequency of Primary Salivary Gland Follicular Lymphoma

Itami

Nakamine²,

Takeda

et al. 2018

Int J Surg Pathol

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Although it has been described that extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) are the most common type among primary salivary gland lymphomas (SGLs), some studies revealed that the frequency of follicular lymphomas (FLs) was as high as that of MALT lymphomas. However, it has been reported that many of these FLs may have developed in lymph nodes attached to the capsule of the glands or intraglandular lymph nodes. Clinical, histological, immunohistochemical, and cytogenetic features of 11 SGL cases, which were extracted from our surgical pathology file consisting of consecutive pathology cases, were reevaluated to further characterize whether they were actually primary SGLs. There were 3 (27%) cases of FLs, 5 (46%) cases of MALT lymphomas, and 3 (27%) cases of diffuse large B-cell lymphomas. Although all of our FL cases fulfilled the criteria of primary SGL, tumors of several FL cases were surrounded by podoplanin (by D2-40)-positive elongated vessels or linear structures indicative of nodal subcapsular sinuses (open or remnant). This finding would support the aforementioned possibility, and podoplanin staining is necessary before concluding that a FL is a primary SGL.

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“…Hodgkin lymphoma presenting as a primary parotid mass is rare, representing only 3.5% to 6% of primary parotid gland lymphomas and 0.3% of all Hodgkin lymphoma cases in general. 10,11,13 To date, <10 cases have been reported in the literature. 14,15 We are aware of only a single-case report of NLPHL involving the parotid gland.…”

Section: Discussionmentioning

confidence: 99%

Intraparotid Classical and Nodular Lymphocyte-predominant Hodgkin Lymphoma

Agaimy

Wild

Märkl³

et al. 2015

American Journal of Surgical Pathology

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Most of the lymphoproliferative diseases involving the salivary glands represent indolent non-Hodgkin B-cell lymphoma (marginal zone lymphoma) related to chronic autoimmune sialadenitis (Sjögren disease). Other types of non-Hodgkin lymphomas involve the salivary glands less frequently. On rare occasions, classical Hodgkin lymphoma (CHL) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) present initially as a primary salivary gland mass. We analyzed a series of CHL (n=3) and NLPHL (n=6) presenting initially as parotid gland tumors concerning their pattern (parenchymal vs. intraparotid lymph node) and the presence of salivary inclusions and epithelial proliferations within the lymphoma infiltrate. The pattern of infiltration was determined on hematoxylin and eosin-stained slides assisted by immunostaining for pancytokeratin to highlight lobular salivary gland parenchyma. Patients included 6 male and 3 female individuals with a mean age of 62 years (range, 36 to 88 y). Lymphoma was localized within intraparotid lymph nodes in 8 cases and was limited to salivary parenchyma in 1 case. Parenchymal involvement in nodal-based cases was scored as absent (3) or minimal (5). Salivary inclusions (acini and ductules) within affected lymph nodes were noted in 6 cases (4/5 NLPHLs and 2/3 CHLs). In 3/6 NLPHL cases, salivary inclusions showed variable proliferative changes ranging from prominent lymphoepithelial lesions to cystic and oncocytic (Warthin-like) epithelial changes. Scanty small lymphoepithelial lesions were seen in 1 of the 3 CHL cases. One NLPHL in the intraparotid lymph node was accompanied by prominent lymphoepithelial sialadenitis in the absence of clinical signs of Sjögren disease. This study highlights that a majority of parotid gland Hodgkin lymphomas arise within intraparotid lymph nodes. Frequent entrapment and proliferation of salivary ducts and acini within the lymphoma infiltrate might mimic a variety of benign lymphoepithelial mass-forming lesions (nonsebaceous lymphadenoma, Warthin tumor, and autoimmune sialadenitis). Pancytokeratin stain is helpful for reliable assessment of the background architecture.

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Salivary Gland Lymphoproliferative Disorders: A Canadian Tertiary Center Experience

Cited by 14 publications

References 30 publications

Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases

Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases

Immunohistochemical Reappraisal Regarding the Frequency of Primary Salivary Gland Follicular Lymphoma

Intraparotid Classical and Nodular Lymphocyte-predominant Hodgkin Lymphoma

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