Extrameningeal Complications of Neisseria meningitidis Serogroup W135 Infection

Apicella, Michael A.

doi:10.1086/421030

Cited by 10 publications

(8 citation statements)

References 11 publications

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“…28 An international outbreak of N. meningitidis serogroup W135 disease among pilgrims returning from Saudi Arabia and their contacts was reported in 2000 and 2001, demonstrating the epidemic potential of this serogroup. 8,29 Subsequently, cases were reported in 16 countries.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and molecular characterization of invasive serogroup W135 Neisseria meningitidis strains from 1990 to 2005 in Brazil

Lemos

Harrison

Lenser

et al. 2010

Journal of Infection

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Summary Objective Neisseria meningitidis serogroup W135 has been associated with global outbreaks since the 2000 Hajj. Considering that N. meningitidis serogroup W135 is the third most prevalent serogroup isolated in Brazil in the last 10 years, and the possibility that the Hajj-related N. meningitidis serogroup W135 clone has been causing disease in Brazil, the present study characterized invasive N. meningitidis serogroup W135 isolates recovered in Brazil from 1990 to 2005. Methods The isolates were characterized by serotyping, PorA and PorB VR typing, FetA and 16S rRNA typing, multilocus sequence typing (MLST) and pulsed field gel electrophoresis (PFGE). Results Based on MLST, 73% of the isolates were clustered in one major clone of ST-11 complex/ET37 complex. Strains of this clone had the same STs, serotypes and PorA VR types as found in Hajj-related N. meningitidis serogroup W135 clone. One of these strains had the Hajj-2000 outbreak strain genotype, including 16S rRNA gene sequence 31 and 84% relatedness by PFGE. Conclusion Taken together, these data suggest that the Hajj-related N. meningitidis serogroup W135 clone is present in Brazil but has not yet caused a substantial number of infections. Given the emergence of N. meningitidis serogroup W135 globally and the unpredictability of meningococcal disease epidemiology, continued surveillance for this invasive N. meningitidis serogroup W135 clone is needed for control and prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Phenotypic and molecular characterization of invasive serogroup W135 Neisseria meningitidis strains from 1990 to 2005 in Brazil

Lemos

Harrison

Lenser

et al. 2010

Journal of Infection

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“…Since 2000, N. meningitidis W135 ST11 disease has become a serious problem worldwide ( 8 , 9 ). In mainland China, serogroup W135 ST11 cases have recently been reported in Guangdong, Guangxi, Zhejiang, Jiangsu, and Henan Provinces ( 10 ), but no deaths were reported until 2012, when the first of the 2 boys died in Anhui Province (Technical Appendix).…”

mentioning

confidence: 99%

Neisseria meningitidisSerogroup W135 Sequence Type 11, Anhui Province, China, 2011–2013

Hu¹,

Zhang²,

Li³

et al. 2014

Emerg. Infect. Dis.

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“…ST-11 serogroup W infection has been reported to cause invasive disease in Africa, Asia, Latin America, and the Middle East. 4 Cases with the ST-11 serogroup W clone have been reported in southeast China and detected in close contacts and healthy carriers. 5 CC4821 is generally associated with serogroup C, and this clone has been a dominant lineage circulating in China since 2003.…”

Section: Discussionmentioning

confidence: 99%