Extramedullary plasmacytoma of the larynx

Mochimatsu, Izumi; Tsukuda, Mamoru; Sawaki, S; Nakatani, Yukio

doi:10.1017/s0022215100125241

Cited by 13 publications

(11 citation statements)

References 10 publications

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“…In a study on 25 cases, reported by Sunsnerwala et al, the median survival rate was 68 months for EMP [ 19 ] and 14.5 for MM arising from EMP [ 18 ]. A long follow-up is advisable as EMP may have long time intervals between relapse and progression to MM, even as long as 10 years [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Extramedullary Plasmacytoma of the Larynx Treated by a Surgical Endoscopic Approach and Radiotherapy

Pino

Farri²,

Garofalo

et al. 2015

Case Reports in Otolaryngology

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Extramedullary plasmacytoma (EMP) is a rare variant of plasma cell myeloma that affects soft tissues. The head and neck region are the most affected sites, although others have also been described. Herein we report an uncommon case of EMP of the larynx in a 65-year-old male who presented with a history of progressive dysphonia and hoarseness. Laryngeal fiberscopy evidenced a reddish pedicled voluminous mass in the left false cords and ventricle. Microscopic suspension laryngoscopy was performed under general anaesthesia and a 4 W Acublade CO2 Laser was used for transoral resection of the lesion. This was followed by adjuvant radiotherapy, with the widely recommended doses on the supraglottic region, to achieve better local control. Diagnosis of EMP is based on immunohistochemistry and the exclusion of systemic plasma cell proliferative disorders. Diagnosis of solitary EMP can be made only if studies for disseminated disease and X-ray and/or magnetic resonance imaging of the spine, pelvis, femurs, and humerus and bone marrow biopsy are negative. As there are no internationally established guidelines, treatment of EMP is mainly based on consensus of expert opinion.

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Section: Discussionmentioning

confidence: 99%

Extramedullary Plasmacytoma of the Larynx Treated by a Surgical Endoscopic Approach and Radiotherapy

Pino

Farri²,

Garofalo

et al. 2015

Case Reports in Otolaryngology

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“…As a matter of fact EMP may evolve to MM many months or years later after diagnosis [14,15]. When a plasma cell tumor involving the larynx is diagnosed the next step is to exclude systemic disease.…”

Section: Discussionmentioning

confidence: 99%

Thyroid cartilage involvement in patient affected by IgA multiple myeloma: Case report

Sciandra

Saraniti

2008

Auris Nasus Larynx

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Neoplasms originating from plasma cell are rare in the head and neck region. A correct clinical evaluation is very important in order to formulate a differential diagnosis as well as to distinguish local from metastatic disease. We report a case of larynx involvement by an IgA multiple myeloma in a 69-year-old female diagnosed in October 2004 and treated with chemotherapy; the 1 year control do not show progression of disease and the laryngeal lesion is unchanged. We highlight the radiological findings and clinical features to suspect plasma cell tumors in cases with a similar presentation. #

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“…Suele presentarse durante la 6ª-7ª déca-da. En el 90% de los casos se localizan en cabeza y cuello (fosa nasal, seno maxilar y nasofaringe) 4 , otras localizaciones son pulmón (5%), ganglios linfáticos (5%), tracto gastrointestinal y piel. Típica-mente en pulmón se presenta como nódulo pulmonar solitario, menos frecuente como consolidación pulmonar o en forma de infiltrados difusos 5 .…”

Section: Discussionunclassified

“…Por último mencionar que es imprescindible un buen seguimiento del paciente tras el tratamiento ya que no son infrecuentes las recidivas tanto locales, que pueden anunciar la diseminación tumoral 4 , como sistémicas (35-50%), sobretodo de vías aéreas bajas, pulmón, tubo digestivo y piel que metastarizan más rápido y presentan peor pronóstico así como la progresión a mieloma múltiple (20-30%).…”

Section: Discussionunclassified

Plasmocitoma endobronquial

Guerrero¹,

Orozco

Villalobos

et al. 2006

Oncología (Barc.)

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ResumenEl plasmocitoma extramedular se define como un tumor poco frecuente de células plasmáticas originado primariamente en tejidos blandos (extraóseos) en ausencia de enfermedad generalizada. La localización pulmonar es extremadamente rara, supone el 5% de los mismos.Existen pocas aportaciones a la literatura sobre esta entidad. Presentamos un caso clínico de plasmocitoma endobronquial en una mujer de 67 años que debutó con un cuadro de neumonía y derrame paraneumónico de repetición. Fue tratado con ablación con láser mediante broncoscopio rígido. Los controles fibrobroncoscópicos posteriores y el seguimiento clínico y analítico posterior confirman la ausencia de enfermedad 14 meses después de su diagnóstico. SummaryExtramedullary plasmacytoma is a little frequent plasma cell tumor originating mainly in the soft tissues (extramedullary) in the absence of generalized disease. Lung localization is very rare, comprising 5% of the cases.There are few literature contributions about this entity. We present a clinical case of endobronchial plasmacytoma of a 67 year old woman presented with a picture of pneumonia and recurrent parapneumonic efussion. She was treated with laser ablation using a rigid bronchoscope. The subsequent fibrobronchoscopic controls and the clinical and analytical follow up confirmed the absence of disease 14 months after the diagnosis.

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Extramedullary plasmacytoma of the larynx

Cited by 13 publications

References 10 publications

Extramedullary Plasmacytoma of the Larynx Treated by a Surgical Endoscopic Approach and Radiotherapy

Extramedullary Plasmacytoma of the Larynx Treated by a Surgical Endoscopic Approach and Radiotherapy

Thyroid cartilage involvement in patient affected by IgA multiple myeloma: Case report

Plasmocitoma endobronquial

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