Extramammary Paget's disease and anaplastic basaloid small-cell carcinoma of the anus

Jackson, B. Richard

doi:10.1007/bf02587397

Cited by 17 publications

(1 citation statement)

References 7 publications

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“…Kubota et al 6 reviewed 28 cases of perianal Paget's disease associated with anorectal carcinoma. 1,5,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] We found continuity between the primary anal canal carcinoma and the perianal lesion in the epidermis in our patient. The Paget's cells were scattered from the distal surgical margin of the anal canal adenocarcinoma to the epidermis of the perianal skin, forming some glandular structures.…”

Section: Discussionmentioning

confidence: 87%

Anal Canal Carcinoma with Pagetoid Spread: Report of a Case

et al. 2006

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A 70-year-old man with a history of colon polyps was found to have a semipedunculated polyp in the anal canal. The patient was asymptomatic. The lesion was 14 mm in diameter and located 5 mm from the dentate line. Histological examination of biopsy specimens revealed well-differentiated adenocarcinoma of the anal canal. During transanal local excision of the tumor, an abnormality of the perianal skin was recognized. Although intraoperative frozen section of the perianal skin did not show malignancy, permanent sections of the perineal skin revealed Paget's cells in the epidermis. Pathological examination of the anal canal carcinoma revealed submucosally invasive well-differentiated adenocarcinoma with a positive distal surgical margin. Thus, we performed additional wide local excision of the perianal skin including the distal margin of the previous local excision. Pathological examination revealed continuance within the epidermis between the anal canal adenocarcinoma and Paget's cells in the perianal skin lesion. Scattered Paget's cells also formed some glandular structures. Thus, we concluded that the perianal skin lesion was Pagetoid spread of anal canal adenocarcinoma. This report shows that the perianal skin should be examined carefully in patients with anal canal carcinoma.

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Section: Discussionmentioning

confidence: 87%

Anal Canal Carcinoma with Pagetoid Spread: Report of a Case

et al. 2006

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Paget's disease primarily involving the scrotum

Pérez

LaRossa

Tomaszewski

1989

Cancer

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Three cases of Paget's disease primarily involving the scrotum are reported. One case exhibited positive staining for prostate specific antigen (PSA) and was associated with an underlying, invasive poorly differentiated adenocarcinoma of unknown primary. The other cases were not associated with any underlying or visceral malignancy. The literature on Paget's disease primarily involving the scrotum including clinical presentation, differential diagnosis, treatment, prognosis, and possible histogenetic mechanisms of this disease is discussed.

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Analregion

Remmele¹

1984

Pathologie: Ein Lehr- Und Nachschlagebuch

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Extramammary Paget's disease and anaplastic basaloid small-cell carcinoma of the anus

Cited by 17 publications

References 7 publications

Anal Canal Carcinoma with Pagetoid Spread: Report of a Case

Anal Canal Carcinoma with Pagetoid Spread: Report of a Case

Paget's disease primarily involving the scrotum

Analregion

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