1990
DOI: 10.1111/j.1600-0560.1990.tb00099.x
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Extramammary Paget's disease:

Abstract: We examined 32 cases (38 lesions) of extramammary Paget's disease (EMPD) in relation to comparative studies on intraductal carcinoma of the breast (ductal carcinoma in situ, DCIS) and apocrine adenocarcinoma (AAC). Lesions included scrotum (18 lesions), vulva (8), axilla (6), groin (3), penis (2) and chest wall (1), and the distribution was compatible with that of apocrine or supernumerary mammary glands. Histologically, extra‐mammary Paget's and DCIS cells exhibited a large amount of a pale‐stained cytoplasm.… Show more

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Cited by 70 publications
(42 citation statements)
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“…Discussion Axillary extramammary Paget's disease is a rare entity. It generally occurs in the genital regions [1]. In this case, it was a primary form of extramammary Paget's disease since b⅛⅜⅜r M Fig.…”
mentioning
confidence: 83%
See 1 more Smart Citation
“…Discussion Axillary extramammary Paget's disease is a rare entity. It generally occurs in the genital regions [1]. In this case, it was a primary form of extramammary Paget's disease since b⅛⅜⅜r M Fig.…”
mentioning
confidence: 83%
“…#" * ■ # • no underlying internal malignancy could be found. This is the situation for the majority of such cases [1]. This pathology must be distinguished histologically very clearly from a pagetoid form of Bowen's disease and from an in situ melanoma [2].…”
mentioning
confidence: 99%
“…Adnexotropism of neoplastic cells in EMPD is well known. 10 In some cases of EMPD, we observed foci in which the neoplastic cells invaded the stroma from involved adnexal structures (hair follicles, apocrine, and eccrine glands) deep in the dermis. This pattern contrasts with the type of microinvasion defined by Feuer et al 33 who described invasion by the neoplastic elements to a depth of no more than 1 mm below the basement membrane of the surface epithelium.…”
Section: Microscopic Featuresmentioning
confidence: 96%
“…Various origins have been proposed including apocrine glands, eccrine glands, hair follicles, 1-8 anogenital mammary-like glands, Toker cells, or pluripotential stem cells in the epidermis. [9][10][11][12][13][14] Unlike mammary Paget disease, EMPD is seldom associated with an underlying ductal carcinoma in situ or invasive carcinoma except for those cases that arise within an anogenital mammary-like glands. [15][16][17][18] In contrast, syringoma is a benign adnexal neoplasm occurring in the superficial dermis.…”
Section: Introductionmentioning
confidence: 99%
“…b Lichen sclerosus Multifokalität erklären. Diskutiert wird auch eine Abstammung von extramammärem Brustdrüsengewe-be[53]. Neuere Daten legen jedoch die Vermutung nahe, dass es sich nicht um extramammäres Brustdrüsengewebe handelt, sondern eher um speziell differenzierte ortsständige Drüsen der Anogenitalregion[56].…”
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