Extraintestinal manifestations in inflammatory bowel disease

Danese, Silvio; Semeraro, S; Papa, Alfredo; Roberto, I.; Scaldaferri, Franco; Fedeli, G.; Gasbarrini, Giovanni; Gasbarrini, Antonio

doi:10.3748/wjg.v11.i46.7227

Cited by 297 publications

(265 citation statements)

References 109 publications

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“…Only rarely is surgery necessary to control the EIMs of UC ( 308,309 ). Previously, patients with severe progressive pyoderma gangrenosum, in whom the pyoderma activity paralleled the activity of the colitis, required surgery ( 310 ); however, infl iximab ( 311 -313 ) has been found eff ective in healing pyoderma gangrenosum, and should therefore be tried before resorting to surgery for this indication.…”

Section: The Patient With Severe Colitis Refractory To Maximal Oral Tmentioning

confidence: 99%

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Kornbluth

Sachar

2010

American Journal of Gastroenterology

1,140

977

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Guidelines for clinical practice are aimed to indicate preferred approaches to medical problems as established by scientifi cally valid research. Double-blind placebo controlled studies are preferable, but compassionate-use reports and expert review articles are used in a thorough review of the literature conducted through Medline with the National Library of Medicine. When only data that will not withstand objective scrutiny are available, a recommendation is identifi ed as a consensus of experts. Guidelines are applicable to all physicians who address the subject regardless of specialty training or interests and are aimed to indicate the preferable but not necessarily the only acceptable approach to a specifi c problem. Guidelines are intended to be fl exible and must be distinguished from standards of care, which are infl exible and rarely violated. Given the wide range of specifi cs in any healthcare problem, the physician must always choose the course best suited to the individual patient and the variables in existence at the moment of decision. Guidelines are developed under the auspices of the American College of Gastroenterology and its Practice Parameters Committee and approved by the board of trustees. Each has been intensely reviewed and revised by the Committee, other experts in the fi eld, physicians who will use them, and specialists in the science of decision analysis. The recommendations of each guideline are therefore considered valid at the time of composition based on the data available. New developments in medical research and practice pertinent to each guideline will be reviewed at a time established and indicated at publication to assure continued validity. The recommendations made are based on the level of evidence found. Grade A recommendations imply that there is consistent level 1 evidence (randomized controlled trials), grade B indicates that the evidence would be level 2 or 3, which are cohort studies or case -control studies. Grade C recommendations are based on level 4 studies, meaning case series or poor-quality cohort studies, and grade D recommendations are based on level 5 evidence, meaning expert opinion.

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Section: The Patient With Severe Colitis Refractory To Maximal Oral Tmentioning

confidence: 99%

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Kornbluth

Sachar

2010

American Journal of Gastroenterology

1,140

977

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“…Our study shows that an underlying product of the inflammatory process, nitrite, also undergoes considerable cycling throughout the disease, dipping to vanishingly low levels and suddenly rising to values many-fold above basal ones. Secondly, IBD is often accompanied by complications in distal organs, including the liver and the kidney, for reasons that are yet unclear 67 . Our findings show that those two organs are the main targets of nitrite overload and significant oxidative stress.…”

Section: Links Between Nitrite Ascorbate Status and The Pathology Ofmentioning

confidence: 99%

On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease

et al. 2010

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“…[15][16][17][18][19] Factores protectores y de riesgo asociados a l d e s a r r o l l o d e l a e n f e r m e d a d : n i v e l socioeconómico, antecedentes personales y familiares de patología autoinmune, tabaquismo, vacunación, lactancia materna, apendicectomía, crisis emocional y antecedente de infecciones bacterianas o virales de jerarquía.…”

Section: Datos Clínicosunclassified

Registro prospectivo durante un año de enfermedad inflamatoria intestinal en población pediátrica argentina

2017

Arch Argent Pediat

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RESUMENIntroducción. La enfermedad inflamatoria intestinal (EII) comprende la colitis ulcerosa (CU) y la enfermedad de Crohn (EC). Su diagnóstico es cada vez más frecuente en pediatría y la incidencia es desconocida en Argentina. El objetivo de este trabajo fue determinar la incidencia anual de EII en menores de 18 años de nuestro país, los aspectos epidemiológicos y las formas clínicas de presentación. Población y métodos. Estudio prospectivo, multicéntrico y observacional que abarcó todo el territorio nacional. Se incluyeron menores de 18 años con diagnóstico de EII de centros públicos y privados entre el 1/6/2012 y el 31/5/2013, a través de protocolo en la web. Resultados. Participaron 17 centros, y se registraron 50 pacientes en 10 centros. La incidencia fue 0,4/100 000 < 18 años; EC, 20; CU, 25; y EII no clasificable, 5. Distribución según sexo: 26 varones y 24 mujeres. La edad media al momento del diagnóstico fue de 9,7 años y la demora diagnóstica, de 16,5 meses. Los síntomas y signos más frecuentes fueron diarrea crónica con sangre y/o moco, dolor abdominal y adelgazamiento. El retraso del crecimiento fue menor de lo esperado. Las manifestaciones extraintestinales se presentaron en el 24% en CU y en el 25% en EC. La localización más frecuente en EC fue ileocolónica, y, en CU, pancolónica. No se observó CU con formas graves. Conclusiones. La incidencia fue menor que la reportada por otros registros. Se considera conveniente la creación de un registro permanente, que no solo permita conocer la incidencia, sino también servir de apoyo a los centros referentes que diagnostican y tratan esta patología. INTRODUCCIÓNLa enfermedad inflamatoria intestinal (EII) comprende la colitis ulcerosa (CU) y la enfermedad de Crohn (EC). Se reconoce una tercera forma llamada enfermedad inflamatoria intestinal no clasificable (EIINC). Los criterios diagnósticos s e b a s a n e n l o s c r i t e r i o s P o r t o que consideran aspectos clínicos, r a d i o l ó g i c o s , e n d o s c ó p i c o s e histológicos.

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Extraintestinal manifestations in inflammatory bowel disease

Cited by 297 publications

References 109 publications

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease

Registro prospectivo durante un año de enfermedad inflamatoria intestinal en población pediátrica argentina

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