Extraintestinal Manifestations in Children With Gastrointestinal Food Allergy

Domínguez-Ortega, Gloria; Borrelli, O.; Dziubak, Robert; Koker, Claire De; Godwin, Heather; Fleming, Catharine; Thapar, Nikhil; Elawad, Mamoun; Kiparissi, F.; A, Fox; Shah, Neil

doi:10.1097/mpg.0000000000000391

Cited by 24 publications

(23 citation statements)

References 33 publications

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“…These findings are consistent with the majority of other studies [9, 28, 29, 39, 40], and indicate that a significant subgroup of women with SFH have poor health and comorbidities.…”

Section: Discussionsupporting

confidence: 92%

Self-Reported Food Hypersensitivity: Prevalence, Characteristics, and Comorbidities in the Norwegian Women and Cancer Study

et al. 2016

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BackgroundThis study aims to investigate the prevalence of self-reported food hypersensitivity, (SFH), the characteristics of women with SFH, and whether SFH is associated with multiple health complaints among the participants of the Norwegian Women and Cancer study (NOWAC).MethodsWe conducted a cross-sectional study among 64,316 women aged 41–76 years. The women were randomly selected from the Norwegian Central Person Register. Information on SFH and all covariates except age and place of residence was collected by questionnaires in 2002–2005.ResultsThe prevalence of SFH in our study sample was 6.8% (95% confidence interval: 6.7–7.0). Logistic regression analysis showed a negative association between SFH and age (odds ratio [OR] 0.97). The odds of SFH increased among women living in or near urban centers, women with more than 9 years of education, women who did not have full-time work, women who had experienced poor economic conditions in childhood, those living without a partner, and those who did not consume alcohol or smoke (OR varied from 1.10 to 1.70). Women with a low body mass index had higher odds of SFH (OR 1.37) than those with a moderate body mass index. SFH was positively associated with poor self-perceived health (OR 2.56). The odds of SFH increased with the number of concurrent health complaints, with an OR for 5–6 comorbidities of 4.93.ConclusionWe found an association between SFH, poor health, and different socio demographic and lifestyle characteristics. Women with SFH had increased odds of reporting multiple health complaints.

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“…These findings are consistent with the majority of other studies [9, 28, 29, 39, 40], and indicate that a significant subgroup of women with SFH have poor health and comorbidities.…”

Section: Discussionsupporting

confidence: 92%

Self-Reported Food Hypersensitivity: Prevalence, Characteristics, and Comorbidities in the Norwegian Women and Cancer Study

et al. 2016

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“…1,3 In this study, we also found some of the extra-intestinal manifestations associated with feeding difficulties, supporting our hypothesis that the presence of these symptoms is associated with feeding difficulties. Dominguez-Ortega et al 34 presented these manifestations as common complaints in children with FPGIA. The exact pathophysiology has yet to be established, and one can only hypothesize that the association we found with feeding difficulties is related to the severity of allergic disorder and/or activated mucosal mast cells which are closely related to mucosal nerves.…”

Section: Discussionmentioning

confidence: 99%

Feeding difficulties in children with food protein‐induced gastrointestinal allergies

Meyer

Rommel

Oudenhove

et al. 2014

J of Gastro and Hepatol

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“…Although the gut‐brain axis has been well described by many authors, the association between non‐IgE‐mediated gastrointestinal food allergies and extra‐intestinal manifestations is relatively new . Dominguez‐Ortega et al described EIM in children with non‐IgE‐mediated food allergies and found them to be increased compared to a control group of IBD patients. In 84.4% of children with this food allergy, EIM were reported, including fatigue, mouth ulcers, joint pain/hypermobility (ie, Ehlers‐Danlos syndrome), night sweat, poor sleep, headache and enuresis.…”

Section: Extra‐intestinal Manifestations (Eim)mentioning

confidence: 98%

Non‐IgE‐mediated gastrointestinal allergies—Do they have a place in a new model of the Allergic March

Fox

Lozinsky

Michaelis

et al. 2019

Pediatric Allergy Immunology

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The rise in food allergy has been described as the “second wave” of the allergy epidemic, with some developed countries reporting a prevalence of 10% of challenge‐proven food allergies. Recognition of the Allergic March has played a crucial role in identifying causality in allergic conditions, linking atopic dermatitis to food allergy and food allergy to other atopic disorders, thereby highlighting opportunities in prevention and the importance of early intervention. This publication will establish the value of weaving the less well‐understood, non‐IgE‐mediated food allergy into the Allergic March and mapping its progression through childhood and its associated co‐morbidities. The proposed non‐IgE‐mediated Allergic March highlights the concomitant presentation of gastrointestinal symptoms and atopic dermatitis as early presenting symptoms in confirmed non‐IgE‐mediated allergies and the later development of atopic co‐morbidities, including asthma and allergic rhinitis, similar to the IgE‐mediated Allergic March. This publication highlights recent observations of a link between non‐IgE‐mediated food allergy in early childhood and functional gastrointestinal disorders in later life and also the reported occurrence of extra‐intestinal manifestations at later ages. Although significant limitations exist in regard to the proposed evolution of the Allergic March model, the authors hope that this publication will influence the management of non‐IgE‐mediated gastrointestinal allergies and inform future research and interventions.

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Extraintestinal Manifestations in Children With Gastrointestinal Food Allergy

Abstract: GIFA are commonly associated with a wide range of EIM, which appear to represent important and specific clinical features of this group of conditions. Their recognition in taking an allergy-focused history may play an important role for both diagnosis and management.

Cited by 24 publications

References 33 publications

Self-Reported Food Hypersensitivity: Prevalence, Characteristics, and Comorbidities in the Norwegian Women and Cancer Study

Self-Reported Food Hypersensitivity: Prevalence, Characteristics, and Comorbidities in the Norwegian Women and Cancer Study

Feeding difficulties in children with food protein‐induced gastrointestinal allergies

Non‐IgE‐mediated gastrointestinal allergies—Do they have a place in a new model of the Allergic March

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