Extraintestinal Campylobacter jejuni and Campylobacter coli Infections: Host Factors and Strain Characteristics

Blaser, Martin J.; Perez, Guillermo I. Perez; Smith, Paul F.; Patton, C M; Tenover, Fred C.; Lastovica, Albert J.; Wang, Wen-Ian L.

doi:10.1093/infdis/153.3.552

Cited by 120 publications

(80 citation statements)

References 26 publications

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“…Essentially, upon infection, certain bacterial ganglioside mimics may facilitate the development of auto-antibodies to ganglioside structures present on the neurons of the host, leading to a temporary infection-associated paralysis [33]. Approximately 50-60% of C. jejuni isolates are able to express such sialic acid-containing ganglioside mimic sugar structures on their cell envelope [36], structures that have also been reported to promote intestinal epithelial cell invasion [37][38][39], human serum resistance [40,41] and the ability to induce severe colitis in humans and monkeys [32,42].…”

Section: Historical Backgroundmentioning

confidence: 99%

“…Remarkably, patients without bacteremia do get hospitalized with Campylobacter-related complications due to the reported presence of these bacteria in cerebrospinal fluid [40], liver [70,71], thyroid gland [72], joints [73], bursitis [74], brain [75], axillary nerve [76], bone [77] and even heart [78,79]. The detection of Campylobacter in these parts of the human body strongly suggests that Campylobacter species are able to travel through the patient's circulatory system without causing actual serious bacteremia that requires hospitalization, at least in the first days of infection.…”

Section: Timing Of Detection In Hospitalsmentioning

confidence: 99%

See 1 more Smart Citation

Campylobacterbacteremia: A rare and under-reported event?

Louwen¹,

Baarlen²,

Vliet³

et al. 2012

European Journal of Microbiology and Immunology

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Section: Historical Backgroundmentioning

confidence: 99%

Section: Timing Of Detection In Hospitalsmentioning

confidence: 99%

Campylobacterbacteremia: A rare and under-reported event?

Louwen¹,

Baarlen²,

Vliet³

et al. 2012

European Journal of Microbiology and Immunology

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“…C. jejuni isolates were generally susceptible to the bactericidal activity in normal human serum by both antibody and complement. Moreover, classical and alternative pathways may contribute to killing C. jejuni (22), although isolates from extraintestinal places show greater serum resistance than gastrointestinal isolates (9).…”

mentioning

confidence: 99%

Inflammatory and Phagocytic Response to Experimental Campylobacter jejuni Infection in Mice

Pancorbo

Gallego

Pablo

et al. 1994

Microbiology and Immunology

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After intraperitoneal inoculation with Campylobacter jejuni BALB/c, Swiss and DBA mice show a peritoneal inflammatory response of different intensity. Only BALB/c mice have a strong peritoneal response. Simultaneous intraperitoneal inoculation of C. jejuni plus FeCl3 increase both inflammatory response and phagocytic activity in Swiss mice, without production of diarrhea. Some thermostable compounds of C. jejuni have a very strong chemotactic activity against peritoneal cells of mice, whereas a diffusible, thermolabile and glutaraldehyde-resistant factor has an inhibitory effect over murine peritoneal cell phagocytosis. Bactericidal activity of peritoneal cells increased after in vitro re-challenge with C. jejuni. Bacteremia is present in all the mice strains tested, but the clearance is quick in DBA and slow in BALB/c and Swiss mice. These experiments confirm that in mice, peritoneal non-specific mechanisms of defense, such as macrophages, play an important role in order to control C. jejuni infection.

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“…de Campylobacter posteriormente a infeção intestinal (Blaser et al, 1986;Selander, 1993;Butzler, 2004;Man, 2011). As sequelas mais relevantes incluem a síndrome de Guillan-Barré, síndrome de Miller-Fisher, síndrome de Reyter´s e a síndrome Hemolítico-urêmica (Gillespie et al, 2002).…”

Section: Manifestações Clínicas E Patogêneseunclassified

“…Além disso, dados da literatura reportam C. coli como a causa de diversas manifestações extra-gastrointestinais tais como bacteremia, sepse, meningite, aborto, dentre outras (Blaser et al, 1986;Selander, 1993;Man, 2011).…”

Section: Especificamente 1 a 25% De Todas As Doenças Causadas Por Baunclassified

Caracterização molecular de linhagens de Campylobacter coli isoladas de origens diversas

Gomes¹

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Este espaço é dedicado àqueles que, de alguma forma, contribuíram para que esta dissertação fosse realizada. Não sendo viável nomeá-los a todos, há no entanto alguns a quem não posso deixar de manifestar o meu apreço e agradecimento sincero.Á Deus pela benção da vida, proteção e força para superar os obstáculos ao longo da minha jornada.À Profª Drª Juliana Pfrimer Falcão, pela orientação, pelo carinhoso apoio, partilha do saber e as valiosas contribuições para a realização desse trabalho. Acima de tudo, obrigada por continuar a acompanhar-me nesta jornada e por estimular o meu interesse pelo conhecimento. Agradeço pela confiança em mim depositada, pelo empenho, paciência e o exemplo profissional e moral durante todo esse período. Minha profunda admiração. Muito Obrigada por tudo! Á minha querida e amada Mãe pelo amor sem reservas, pelos momentos de carinho e por tornar a minha vida mais colorida. Ao meu Pai pela figura firme e segura que me empurra nos momentos mais difíceis, por tornar possível os meus sonhos e conquistas. Não tenho palavras para descrever esse Amor! Aos meus queridos irmãos Gabriela, Marcos, Carina e ao meu sobrinho João Vitor pelo incentivo, apoio e carinho. Vocês são parte de mim! Á aquele que não leva jeito com as palavras, mas tem um abraço que me acalma, um olhar que me alegra, um sorriso que conforta e um amor que me transforma. Alessandro, "Não me lembro mais qual foi nosso começo. Sei que não começamos pelo começo. Já era amor antes de ser"! strains; the flhA gene was detected in 11 (17.5%) strains; the dnaJ gene was detected in 10 (15.9%) strains; the pldA gene was detected in 7 (11.1%) strains ; the iamA gene was detected in three (4.8%) strains; the cdtC and docA genes were found in two (3.2%) strains; the cdtA and crsA were found in one (1.6%) strain and the ciaB, wlaN, virB11 and racR genes were not detected. Among the 63 strains studied, 42 were susceptible to all antimicrobials tested. Of the 21 resistant strains, 10 (15.9%) were resistante to tetracycline and doxaciclyne, six (9.5%) showed resistance to ciprofloxacin, and one (1.6%) was resistant to erythromycin. Only four (6.3%) strains were simultaneously resistant to at least two different classes of the antibiotics tested. The dendrogram of genetic similarity of Pulsed field gel electrophoresis (PFGE) grouped the 63 strains studied into two groups namely PFGE-A and PFGE-B with a genomic similarity of 44.9% among them. However, some strains isolated from humans, animals, the environment and food presented a high genotypic similarity above 80% and were subdivided into seven groups designated as PFGE-A1 to PFGE-A7. The dendrogram of genetic similarity of the SRV-flaA gene sequences grouped the strains studied into two groups namely SVR-A and SVR-B, with similarity above 83.1% among them. Besides, the deposit of the SVR sequences of the flaA gene in the online database showed that the alleles 30 and 1647 were the iv most frequently found and allowed the comparison between the strains studied with the alleles described in the d...

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Extraintestinal Campylobacter jejuni and Campylobacter coli Infections: Host Factors and Strain Characteristics

Cited by 120 publications

References 26 publications

Campylobacterbacteremia: A rare and under-reported event?

Campylobacterbacteremia: A rare and under-reported event?

Inflammatory and Phagocytic Response to Experimental Campylobacter jejuni Infection in Mice

Caracterização molecular de linhagens de Campylobacter coli isoladas de origens diversas

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