Extrahepatic complications of non-alcoholic fatty liver disease

Velasco, J.A. Velarde-Ruiz; García-Jiménez, E.S.; García-Zermeño, Karla Rocío; Morel-Cerda, Eliana C; Aldana-Ledesma, J.M.; Castro-Narro, Graciela; Cerpa-Cruz, Sergio; Tapia-Calderón, D.K.; Mercado-Jauregui, L.A.; Contreras-Omaña, R.

doi:10.1016/j.rgmxen.2019.05.004

Cited by 9 publications

(7 citation statements)

References 62 publications

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“…Other causes of prevalence are attributed to genetic and environmental factors, such as lack of exercise and type of diet consumed. (6,10) Regarding human ancestry, Balakrishnan. (1) demonstrated in their study that populations of Hispanic American ancestry have the highest levels of incidence of NAFLD, confirmed by Oliveira, who observed a higher prevalence of NAFLD in people of Native American origin in Latin American populations.…”

Section: Epidemiology Of Nonalcoholic Fatty Liver Diseasementioning

confidence: 99%

Nutrition, obesity and their relationship with liver diseases

Correa Vásconez,

Guanga Lara

2024

Salud, Ciencia y Tecnología - Serie de Conferencias

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Introduction: The frequent consumption of foods high in saturated fat content has been associated with the increasing prevalence of obesity worldwide, especially in developed countries. The aim is to conduct a literature review on nutrition and its relationship with obesity and the emergence of liver diseases. Methods: A literature review was conducted in digital libraries such as PubMed, Scielo, and Latindex, meeting inclusion criteria: years between 2019 and 2023, updated dietary guidelines, official documents, scientific articles, and books in English and Spanish. Results: Non-alcoholic fatty liver disease (NAFLD) is a growing condition, being one of the most relevant chronic liver diseases worldwide, especially in adults, school-age children, and adolescents. It has been associated with obesity, diabetes, and metabolic syndrome, affecting 25-30% of the adult population, with higher prevalence in countries such as Brazil, Chile, and Colombia in Latin America. NAFLD can lead to serious complications such as liver cirrhosis and liver cancer. Prevention includes lifestyle changes such as a balanced diet and regular physical activity, as well as early identification through nutritional screening tools in medical and nutritional consultations. Conclusion: There is a direct relationship between nutrient type, dietary habits, lifestyle, and the emergence of obesity and its complications in liver functions, non-alcoholic fatty liver disease, cirrhosis, and alterations in the functions of other organs.

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Section: Epidemiology Of Nonalcoholic Fatty Liver Diseasementioning

confidence: 99%

Nutrition, obesity and their relationship with liver diseases

Correa Vásconez,

Guanga Lara

2024

Salud, Ciencia y Tecnología - Serie de Conferencias

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“…[ 47 ] It is thought that, in addition to conventional cardiovascular risks factors, such as diabetes, hypertension, and dyslipidemia, many secondary risk factors accompanying NAFLD, such as hyperuricemia, hypoadiponectinemia, and proinflammatory cytokines, may be responsible for the increase in the frequency of CVD in patients with NAFLD. [ 48 ] It should not be forgotten that NAFLD is closely related to cardiovascular mortality and associated with liver-related mortality. The probability of a nonfatal cardiovascular event or death from cardiac causes is increased twice in patients with NAFLD compared to the general population.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

TASL Practice Guidance on the Clinical Assessment and Management of Patients with Nonalcoholic Fatty Liver Disease

Yılmaz¹

2023

Hepatology Forum

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Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease and is significantly associated with obesity, insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease. NAFLD has become the most prevalent chronic liver disease in Western countries, and the proportion of NAFLD-related cirrhosis among patients on liver transplantation waiting lists has increased. In light of the accumulated data about NAFLD, and to provide a common approach with multi-disciplines dealing with the subject, it has become necessary to create new guidance for diagnosing and treating NAFLD. This guidance was prepared following an interdisciplinary study under the leadership of the Turkish Association for the Study of the Liver (TASL), Fatty Liver Special Interest Group. This new TASL Guidance is a practical application guide on NAFLD and was prepared to standardize the clinical approach to diagnosing and treating NAFLD patients. This guidance reflects many advances in the field of NAFLD. The proposals in this guidance are meant to aid decision-making in clinical practice. The guidance is primarily intended for gastroenterology, endocrinology, metabolism diseases, cardiology, internal medicine, pediatric specialists, and family medicine specialists.

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“…Apart from the risk of liver fibrosis/cirrhosis, patients with NAFLD have an increased risk of all-cause mortality, especially due to cardiovascular disease (CVD) [ 38 , 39 , 40 ]. This risk is attributed to the common predisposing factors for both NAFLD and CVD, with the endothelium emerging as a key player [ 41 , 42 , 43 , 44 ].…”

Section: Endothelial Cells In the Pathogenesis Of Nafldmentioning

confidence: 99%

Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review

Nasiri-Ansari

Ανδρουτσάκος

Flessa

et al. 2022

Cells

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Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other metabolic syndrome features. Reflecting the underlying pathogenesis and the cardiometabolic disorders associated with NAFLD, the term metabolic (dysfunction)-associated fatty liver disease (MAFLD) has recently been proposed. Indeed, over the past few years, growing evidence supports a strong correlation between NAFLD and increased cardiovascular disease (CVD) risk, independent of the presence of diabetes, hypertension, and obesity. This implies that NAFLD may also be directly involved in the pathogenesis of CVD. Notably, liver sinusoidal endothelial cell (LSEC) dysfunction appears to be implicated in the progression of NAFLD via numerous mechanisms, including the regulation of the inflammatory process, hepatic stellate activation, augmented vascular resistance, and the distortion of microcirculation, resulting in the progression of NAFLD. Vice versa, the liver secretes inflammatory molecules that are considered pro-atherogenic and may contribute to vascular endothelial dysfunction, resulting in atherosclerosis and CVD. In this review, we provide current evidence supporting the role of endothelial cell dysfunction in the pathogenesis of NAFLD and NAFLD-associated atherosclerosis. Endothelial cells could thus represent a “golden target” for the development of new treatment strategies for NAFLD and its comorbid CVD.

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Extrahepatic complications of non-alcoholic fatty liver disease

Cited by 9 publications

References 62 publications

Nutrition, obesity and their relationship with liver diseases

Nutrition, obesity and their relationship with liver diseases

TASL Practice Guidance on the Clinical Assessment and Management of Patients with Nonalcoholic Fatty Liver Disease

Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review

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