Abstract:BACKGROUND
Extrahepatic biliary duct injury (BDI) remains a complicated issue for surgeons. Although several approaches have been explored to address this problem, the high incidence of complications affects postoperative recovery. As a nonimmunogenic scaffold, an animal-derived artificial bile duct (ada-BD) could replace the defect, providing good physiological conditions for the regeneration of autologous bile duct structures without changing the original anatomical and physiologic conditions.
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“…37–39 In previous studies, pigs were employed as large animals to create a model of bile duct loss and explore the regeneration of the extrahepatic bile duct. 39–41 However, there are certain limitations associated with the use of pigs as experimental animals. Due to their physiological and structural characteristics, pigs have a substantial body weight and a thick subcutaneous fat layer, which poses challenges during surgical implantation and postoperative sampling.…”
In this study, a 3D porous poly(ε-caprolactone)/polyethylene glycol (PCL/PEG) composite artificial tubular bile duct was fabricated for extrahepatic bile duct regeneration. PCL/PEG composite scaffolds were fabricated by 3D printing, and...
“…37–39 In previous studies, pigs were employed as large animals to create a model of bile duct loss and explore the regeneration of the extrahepatic bile duct. 39–41 However, there are certain limitations associated with the use of pigs as experimental animals. Due to their physiological and structural characteristics, pigs have a substantial body weight and a thick subcutaneous fat layer, which poses challenges during surgical implantation and postoperative sampling.…”
In this study, a 3D porous poly(ε-caprolactone)/polyethylene glycol (PCL/PEG) composite artificial tubular bile duct was fabricated for extrahepatic bile duct regeneration. PCL/PEG composite scaffolds were fabricated by 3D printing, and...
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