Extragastrointestinal stromal tumor of prostate

Abstract

Gastrointestinal stromal tumors (GISTs) that originate outside the GI tract are extremely uncommon. In this case report, we describe a GIST of primary origin in the prostate gland of an 84-year-old male who presented with severe urinary retention at King Abdulaziz University Hospital in Saudi Arabia. Diagnosis was based on patient history, radiological studies, pathologic findings, and immunohistochemical data. Digital rectal examination revealed a hugely enlarged prostate encroaching upon the rectal lumen with a smooth and firm surface. Transrectal ultrasound showed a markedly enlarged prostate with an estimated volume of 360 ml; prostate-specific antigen was 5.4 ng/ml. Immediate preoperative cystoscopy demonstrated only a moderate enlargement of the prostate, which was disproportionate to its actual size. Postoperative abdominal computed tomography showed residual prostatic tissue with an estimated weight of 78 g, multiple diffuse colonic diverticulosis, and scattered subcentimeter mesenteric lymph nodes. Histopathological examination of the prostatic tissue showed cellular spindle cell neoplastic proliferation which was diffusely positive for CD117 (c-kit), DOG1, and CD34. GISTs must be considered in the differential diagnosis of spindle cell tumors detected in the prostate.

<p>Primary Prostatic Extra-Gastrointestinal Stromal Tumor Treated with Imatinib Mesylate as Neoadjuvant and Adjuvant Therapy: A Case Report and Literature Review</p>

“…Herein, this present case should be the 14th literally reported primary prostatic EGISTs. The major clinical manifestation reported in literature includes frequency, urgency, dysuria, acute urinary retention, vague perineum pain and constipation 9–13. However, some cases were occasionally found by routine general physical examination without any symptoms 14.…”

Advances of endoscopic and surgical management in gastrointestinal stromal tumors

“…Mesentery and omentum are common tumor sites of genuine primary EGISTs ( 91 , 92 ). Other rare and unusual locations are pancreas ( 93 ), prostate ( 94 ), and pleura ( 95 ). With rare and aggressive malignancy, patients with EGISTs often have comparatively poor survival outcome, classified as high-risk lesions ( 96 ).…”