Extrafollicular adenomatoid odontogenic tumour

Abstract

Adenomatoid odontogenic tumour (AOT) is an uncommon, benign tumour that represents 3-7% of all odontogenic tumours. It is slow growing, occurs twice as common in females and usually in the second decade of life. There are three subclinical types of this tumour with identical histology: follicular type (73%), extrafollicular variant (24%) and peripheral form (3%). Here, the authors have presented two rare cases of extrafollicular varieties of AOT in 25-year-old female patients, of which one was situated in the maxillary canine area and the other one situated in an unusual location of mandibular premolar area. Such lesions may be confused as an odontogenic cyst and should be carefully differentiated from other benign and malignant lesions arising in this region.

An Extrafollicular Adenomatoid Odontogenic Tumor Mimicking a Periapical Cyst

“…Since root resorption rarely occurred in AOT lesion, we detected displacement of the adjacent teeth (especially at the right side) and root resorption of the involved teeth [ 2 ]. The size of the current lesion was 3.5 × 2.7 cm; this was is consistent with the size of tumor used in the previous study, which was 1.5–3 cm in diameter [ 24 ]. Yilmaz et al described an AOT causing painless swelling in the anterior mandible which was bony hard with no previous history of trauma, tenderness, discharge, or any other symptoms.…”

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor

“…However, the available reviews in the literature suggest that some extrafollicular AOTs may arise as a secondary phenomenon within pre-existing odontogenic cysts or cystic tumors. For example, the tumor may originate from the epithelial lining of an odontogenic cyst or unicystic ameloblastoma 93,94. A rare subvariant of the extrafollicular type of AOT may radiographically mimic periapical diseases, which is initially suspicious of small periapical pathology.…”

A case report and short review on changing trends in the site of occurrence of adenomatoid odontogenic tumor: Unravelling the past 15 years

“…Adenomatoid odontogenic tumor (AOT) was first elucidated by Driebaldt in 1907 as “pseudo-adenoameloblastoma,” and later as “adenomatoid odontogenic tumor.”[1] The World Health Organization (WHO) in 2005 defined AOT as a tumor composed of odontogenic epithelium, presenting a variety of histo-architectural patterns, embedded in mature connective tissue stroma, and characterized by slow and progressive growth. [2]…”

“…The deformity produced by this lesion manifests as displacement of adjoining teeth and an obvious expansion of the surrounding bone. [12] Sometimes, it may be also as “two-thirds tumor” because:…”