Extracts of Moringa oleifera Lam. showing inhibitory activity against early steps in the infectivity of HIV-1 lentiviral particles in a viral vector-based screening

Nworu,; C, S; Okoye,; E, L; Ezeifeka,; G, O; Esimone,; C, O

doi:10.5897/ajb2013.12343

Cited by 28 publications

(21 citation statements)

References 48 publications

(62 reference statements)

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“…MO was also used as a complement toward antiretroviral treatment in HIV infection (Monera & Maponga, ). MO leaves have generally been utilized in the treatment of HIV‐related side effects, potentially in early strides in the infectivity of HIV‐1 lentiviral particles in a viral vector‐based screening (Nworu, Okoye, Ezeifeka, & Esimone, ). By assessing these researches discussed, it is concluded that MO could be used in the improvement of promising antiviral medications.…”

Section: Resultsmentioning

confidence: 99%

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Dhakad

Ikram

Sharma

et al. 2019

Phytotherapy Research

168

100

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The genus Moringa Adans. comprises 13 species, of which Moringa oleifera Lam. native to India and cultivated across the world owing to its drought and frost resistance habit is widely used in traditional phytomedicine and as rich source of essential nutrients. Wide spectrum of phytochemical ingredients among leaf, flower, fruit, seed, seed oil, bark, and root depend on cultivar, season, and locality. The scientific studies provide insights on the use of M. oleifera with different aqueous, hydroalcoholic, alcoholic, and other organic solvent preparations of different parts for therapeutic activities, that is, antibiocidal, antitumor, antioxidant, anti‐inflammatory, cardio‐protective, hepato‐protective, neuro‐protective, tissue‐protective, and other biological activities with a high degree of safety. A wide variety of alkaloid and sterol, polyphenols and phenolic acids, fatty acids, flavanoids and flavanol glycosides, glucosinolate and isothiocyanate, terpene, anthocyanins etc. are believed to be responsible for the pragmatic effects. Seeds are used with a view of low‐cost biosorbent and coagulant agent for the removal of metals and microbial contamination from waste water. Thus, the present review explores the use of M. oleifera across disciplines for its prominent bioactive ingredients, nutraceutical, therapeutic uses and deals with agricultural, veterinarian, biosorbent, coagulation, biodiesel, and other industrial properties of this “Miracle Tree.”

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Section: Resultsmentioning

confidence: 99%

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Dhakad

Ikram

Sharma

et al. 2019

Phytotherapy Research

168

100

View full text Add to dashboard Cite

show abstract

“…M. oleifera contains a rare combination of important bioactive components like zeatin, quercetin, beta-sitosterol, caffeoylquinic acid, kaempferol etc. Various parts of this plant have been reported to act as antiviral, antibacterial, cardiac and circulatory stimulants, anti-diabetic, hypolipidemic, antiulcer, antipyretic, antispasmodic, anti-inflammatory, antihypertensive, diuretic, antioxidant, and antifungal activities ( Nworu et al., 2013 ) Therefore, it has a great appeal as folk or Ayurvedic traditional medicine in different cultures of the world. Due to its divergent nutritional, pharmacological and industrial applications, the plant is recognized as a “miracle tree” or a “wonder tree”, which bears a significant socio-economic importance.…”

Section: Traditional Foods (Plant Animal and Fungi Species) Having Amentioning

confidence: 99%

“…In the Philippines, the plant is known as ‘mother's best friend’ because of its use to increase women's milk production and sometimes it is also prescribed for anemia ( Estrella et al., 2000 ). Besides its diverge range of medicinal use, the massive antiviral activity is due to the presence of alkaloids, saponins, glycosides, niazimin, terpenoids, and phenolic compounds ( Table 1 ) ( Nworu et al., 2013 ). Previous reports showed that thiocarbamate and niaziminin isolated from M. oleifera were highly efficient to inhibit the activation of tumor promoting virus, Epstein Barr virus (EBV) ( Murakami et al., 1998 ).…”

Section: Traditional Foods (Plant Animal and Fungi Species) Having Amentioning

confidence: 99%

Traditional foods with their constituent's antiviral and immune system modulating properties

Rahman

Mosaddik

Alam

2021

Heliyon

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“…The plant is used to cure more than 300 ailments. Its medicinal properties include; antidiabetic [9], anticancer [10], [11], Neuroprotectant [12], [13], antiulcer [14], antipyretic [15], antihelminthic [16], antiretroviral [17], antiarthritic [18], antimicrobial [19], antioxidant [20], antifertility [21], hepatoprotective activity [22], hypotensive [23], analgesic [24], wound healing [25], anticonvulsant [26] and reported to have inhibitory actions against several viruses including HIV [27], HSV [28], HBV [29], EBV [30], FMDV [31] and NDV [32]. In the present study, a total of 19 leaf compounds were screened and those having higher binding a nity with M pro can be a good target for further anti-viral drug research.…”

Section: Introductionmentioning

confidence: 99%

Computational screening of phytocompounds from Moringa oleifera leaf as potential inhibitors of SARS-CoV-2 Mpro

James

2020

Preprint

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Background: Coronavirus Disease (COVID-19), caused by novel SARS CoV-2 is rapidly spreading all over the World creating a global public health emergency at unprecedented levels. Till today, no effective treatments or vaccines against this global pandemic is reported and hence to identify lead compounds having potential action in controlling the spread the pandemic is a global concern. This study aimed at in silico screening of phytocompounds from M.oleiera leaf against novel SARS CoV-2 main protease (Mpro) through molecular docking. M.oleiera is an Indian medicinal plant as well as a vegetable, all parts of the plant is medicinally useful and is being used in many of the traditional and Ayurvedic medicinal preparations. Result: When the 19 compounds identified from M.oleifera leaf methanolic extract by Liquid Chromatography Mass Spectrometry (LCMS/MS) analysis and 5 FDA approved anti-viral drugs were screened in silico with SARS CoV-2 main protease (Mpro), the following compounds showed top interaction; apigenin-7-O-rutinoside (-8.8 kcal/mol), Mudanpioside (-8.3 kcal/mol), isoquercetin (-8 kcal/mol), isoquercitrin (-8 kcal/mol), quercetin (-7.8 kcal/mol) and dihydroquercetin (-7.8 kcal/mol). Anti-viral drugs: Raltegravir (-7.2 kcal/mol), Lopinavir-Ritonavir (-7.7 kcal/mol), maraviroc (-8.2 kcal/mol), Nelfinavir (-8.3 kcal/mol) and Tipranavir (-9.2 kcal/mol) also showed active interaction with Mpro. Preliminary phytochemical screening of methanol extract showed the presence of flavonoids, cardiac glycosides, phenols, coumarins, saponins, steroids and phytosteroids. In vitro antioxidant activity of methanolic extract of M.oleifera also showed greater activity, which would ameliorate the post-COVID secondary infection. Conclusion: Hence these compounds from M.oleifera, which are our diet based components, which can interact with the Mpro and curtail COVID-19 virus multiplication in the host cell.

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Extracts of Moringa oleifera Lam. showing inhibitory activity against early steps in the infectivity of HIV-1 lentiviral particles in a viral vector-based screening

Abstract: Moringa oleifera

Cited by 28 publications

References 48 publications

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Traditional foods with their constituent's antiviral and immune system modulating properties

Computational screening of phytocompounds from Moringa oleifera leaf as potential inhibitors of SARS-CoV-2 Mpro

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