“…+ N.o. biomass matches with its antiproliferative effect on PNT2 cells, since antioxidant molecules such as vitamins D, E, B 12 or B 6 , among the others, are known to interfere with intracellular viral replication [ 57 , 58 ]. This hypothesis needs to be deeply investigated to be confirmed or refuted.…”
Microalgal biotechnology is gaining importance. However, key issues in the pipeline from species selection towards large biomass production still require improvements to maximize the yield and lower the microalgal production costs. This study explores a co-cultivation strategy to improve the bioactive compounds richness of the harvested microalgal biomass. Based on their biotechnological potential, two diatoms (Skeletonema marinoi, Cyclotella cryptica) and one eustigmatophyte (Nannochloropsis oceanica) were grown alone or in combination. Concentrations of ten vitamins (A, B1, B2, B6, B12, C, D2, D3, E and H), carotenoids and polyphenols, together with total flavonoids, sterols, lipids, proteins and carbohydrates, were compared. Moreover, antioxidant capacity and chemopreventive potential in terms inhibiting four human tumor-derived and normal cell lines proliferation were evaluated. Co-cultivation can engender biomass with emergent properties regarding bioactivity or bioactive chemical profile, depending on the combined species. The high vitamin content of C. cryptica or N. oceanica further enhanced (until 10% more) when co-cultivated, explaining the two-fold increase of the antioxidant capacity of the combined C. cryptica and N. oceanica biomass. Differently, the chemopreventive activity was valuably enhanced when coupling the two diatoms C. cryptica and S. marinoi. The results obtained in this pilot study promote microalgal co-cultivation as a valuable strategy aiming to boost their application in eco-sustainable biotechnology.
“…+ N.o. biomass matches with its antiproliferative effect on PNT2 cells, since antioxidant molecules such as vitamins D, E, B 12 or B 6 , among the others, are known to interfere with intracellular viral replication [ 57 , 58 ]. This hypothesis needs to be deeply investigated to be confirmed or refuted.…”
Microalgal biotechnology is gaining importance. However, key issues in the pipeline from species selection towards large biomass production still require improvements to maximize the yield and lower the microalgal production costs. This study explores a co-cultivation strategy to improve the bioactive compounds richness of the harvested microalgal biomass. Based on their biotechnological potential, two diatoms (Skeletonema marinoi, Cyclotella cryptica) and one eustigmatophyte (Nannochloropsis oceanica) were grown alone or in combination. Concentrations of ten vitamins (A, B1, B2, B6, B12, C, D2, D3, E and H), carotenoids and polyphenols, together with total flavonoids, sterols, lipids, proteins and carbohydrates, were compared. Moreover, antioxidant capacity and chemopreventive potential in terms inhibiting four human tumor-derived and normal cell lines proliferation were evaluated. Co-cultivation can engender biomass with emergent properties regarding bioactivity or bioactive chemical profile, depending on the combined species. The high vitamin content of C. cryptica or N. oceanica further enhanced (until 10% more) when co-cultivated, explaining the two-fold increase of the antioxidant capacity of the combined C. cryptica and N. oceanica biomass. Differently, the chemopreventive activity was valuably enhanced when coupling the two diatoms C. cryptica and S. marinoi. The results obtained in this pilot study promote microalgal co-cultivation as a valuable strategy aiming to boost their application in eco-sustainable biotechnology.
“…A recent review has concluded that the compound epigallocatechin gallate can inhibit Epstein-Barr virus by inhibiting replication; HIV by regulating oxygen level of target cells; arboviruses like Dengue, Chikungunya, West Nile virus, and Zika virus by suppressing infectivity, inhibiting viral RNA replication, and inactivating virus directly; Herpes simplex virus by inhibiting activity; Enterovirus 71 by suppressing viral RNA replication; and HBV by inhibiting viral promoter transcription [253]. Taken together, the available scientific reports suggest that the huge number of flavonoids that are present in various plant species can play a role as therapeutics against old and emerging viruses and that since quite a number of these flavonoids are dietary, they can make for easily available and affordable immune-boosters and anti-viral therapeutics [254].…”
Recent years have witnessed the emergence of several viral diseases, including various zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Other viruses, which possess pandemic-causing potential include avian flu, Ebola, dengue, Zika, and Nipah virus, as well as the re-emergence of SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) coronaviruses. Notably, effective drugs or vaccines against these viruses are still to be discovered. All the newly approved vaccines against the SARS-CoV-2-induced disease COVID-19 possess real-time possibility of becoming obsolete because of the development of ‘variants of concern’. Flavonoids are being increasingly recognized as prophylactic and therapeutic agents against emerging and old viral diseases. Around 10,000 natural flavonoid compounds have been identified, being phytochemicals, all plant-based. Flavonoids have been reported to have lesser side effects than conventional anti-viral agents and are effective against more viral diseases than currently used anti-virals. Despite their abundance in plants, which are a part of human diet, flavonoids have the problem of low bioavailability. Various attempts are in progress to increase the bioavailability of flavonoids, one of the promising fields being nanotechnology. This review is a narrative of some anti-viral dietary flavonoids, their bioavailability, and various means with an emphasis on the nanotechnology system(s) being experimented with to deliver anti-viral flavonoids, whose systems show potential in the efficient delivery of flavonoids, resulting in increased bioavailability.
“…The role of traditional foods (TFs) on society cannot be overstated (Skalkos et al, 2021) due to their various natural nutritional composition (Du Plooy et al, 2018;Rahman et al, 2021;Yulia et al, 2018), promotion of destination attractiveness, and support for local agro-economies (Hsu et al, 2018). While the popularity of traditional foods continues to intrigue people of diverse backgrounds (Braziotis et al, 2013), there are generalised concerns among consumers about the integrity and quality of the foods (Wu et al, 2015).…”
Despite the attention paid to food safety research, few empirical works have used a non-reductionist perspective to understand how international consumers cognitively respond to local food safety conditions. Using the tri-component theorisation and the two-step clustering approach with the Kruskal Wallis test on a sample of 109 international students in Ghana, this study provides a non-reductionist cognitive segment of international students towards local food safety conditions in Ghana. The findings revealed that there are three cognitive segments of international consumers towards local food safety conditions, namely self-regards, pessimists, and epicureans. Self-assureds respond to their own self-cognition towards local food safety concerns but deny the cognition of others, moderately respond affectively and sometimes avoid local foods. Pessimists have a highly sensitive cognitive response towards local food safety conditions, high affective responses and avoid the consumption of local foods as a result, while epicureans do not cognitively respond to local food safety conditions, have low affective reactions and consume local foods regardless of the food safety conditions. The implications of these findings in the context of local food preparation, packaging, and handling as well as food safety regulations and marketing are discussed
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.