Extraction of secondary metabolites from plant material: A review

Starmans, D.A.J.; Nijhuis, Herry H.

doi:10.1016/0924-2244(96)10020-0

Cited by 109 publications

(70 citation statements)

References 26 publications

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“…In order to enhance extraction efficiency, additional energy is put into the system either directly by heat (e.g. 70 • C), or by other techniques such as pressurized liquid extraction (Benthin et al, 1999), supercritical fluid extraction (Castioni et al, 1995;Jarvis and Morgan, 1997;Blanch et al, 1999), sonication (Sargenti and Vichnewski, 2000), subcritical water extraction (Gámiz-Gracia and de Castro, 2000), microwave techniques (Namiesnik and Gorecki, 2000), or pervaporation (Starmans and Nijhuis, 1996). Rarely data are available that compare these techniques and, furthermore, few systematic studies have been carried out on the occurrence of possible metabolite breakdown reactions caused, for example, by oxidation (Peng and Jayallemand, 1991).…”

Section: Metabolomic Sample Preparationmentioning

confidence: 99%

Metabolomics — the link between genotypes and phenotypes

Fiehn

2002

Functional Genomics

1,618

1,337

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Metabolites are the end products of cellular regulatory processes, and their levels can be regarded as the ultimate response of biological systems to genetic or environmental changes. In parallel to the terms 'transcriptome' and 'proteome', the set of metabolites synthesized by a biological system constitute its 'metabolome'. Yet, unlike other functional genomics approaches, the unbiased simultaneous identification and quantification of plant metabolomes has been largely neglected. Until recently, most analyses were restricted to profiling selected classes of compounds, or to fingerprinting metabolic changes without sufficient analytical resolution to determine metabolite levels and identities individually. As a prerequisite for metabolomic analysis, careful consideration of the methods employed for tissue extraction, sample preparation, data acquisition, and data mining must be taken. In this review, the differences among metabolite target analysis, metabolite profiling, and metabolic fingerprinting are clarified, and terms are defined. Current approaches are examined, and potential applications are summarized with a special emphasis on data mining and mathematical modelling of metabolism.

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Section: Metabolomic Sample Preparationmentioning

confidence: 99%

Metabolomics — the link between genotypes and phenotypes

Fiehn

2002

Functional Genomics

1,618

1,337

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“…If solvents with toxic properties are used in the extraction process, they must be removed to a specified residual level in order to be eligible for use in food applications, e.g. 5-30 mg of hexane/kg of product (such as edible oils) (Starmans, 1996).…”

Section: Limitations Of Solvent Extractionmentioning

confidence: 99%

Sinapinic and protocatechuic acids found in rapeseed: isolation, characterisation and potential benefits for human health as functional food ingredients

Quinn

Gray

Meaney³

et al. 2017

Irish Journal of Agricultural and Food Research

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Rapeseed is one of the world’s major oilseeds, and rapeseed oil is produced by pressing of the seeds. This process results in the production of a low-economic-value by-product, rapeseed meal, which is commonly used as animal feed. Rapeseed meal is rich in bioactive phenolic compounds, including sinapinic acid (SA) and protocatechuic acid (PCA). Isolation of these bioactive compounds from a by-product of rapeseed oil production is largely in agreement with the current concept of the circular economy and total utilisation of crop harvest using a biorefinery approach. In this review, current information concerning traditional and novel methods to isolate phenolic compounds – including SA and PCA – from rapeseed meal, along with in vitro and in vivo studies concerning the bioactivity of SA and PCA and their associated health effects, is collated. These health effects include anti-inflammatory, anti-cancer, anti-diabetes activities, along with histone deacetylase inhibition and protective cardiovascular, neurological and hepatic effects. The traditional extraction methods include use of solvents and/or enzymes. However, a need for simpler, more efficient methodologies has led to the development of novel extraction processes, including microwave-assisted, ultrasound-assisted, pulsed electric field and high-voltage electrical discharge extraction processes.

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“…Plant material consists of many different kinds of natural products with nature of different polarities leading to a different mode of solubility [22]. These secondary metabolites are secreted by the plants for their defense which are being used by peoples for various purposes and also are the key candidates in the medicinal value of plants [16] [23].…”

Section: Discussionmentioning

confidence: 99%

Preliminary phytochemical screening and cytotoxic potentials from leaves of Sanchezia speciosa Hook.f

Parvin

Rafshanjani

Kader

et al. 2015

Int J of Adv in Sci Res

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Background: Sanchezia speciosa Hook.f is an important medicinal plant with several ethnomedicinal properties. In the present experiment the leaves of this plant were screened for the presence of major phytochemical groups. The phytochemicals are the wide variety of compounds produced by plants manipulated widely in the pharmacognostic drug development and in the treatment of the major ailments. Methods: Phytochemical screenings were performed by various functional group tests. All the leaves extracts were subjected to brine shrimp lethality bioassay and standard anticancer drug vincristine sulphate was used as positive control. Results: Phytochemical investigation of the leaves extracts showed the presence of alkaloids, glycosides, flavonoids, triterpenoids, carbohydrates, steroids, phenolic compounds, saponins and tannins. The ethyl acetate fractionates of the leaves extracts were positive for all the phytochemicals tested while n-hexane fractionates were negative for flavonoids and phenolic compounds. The n-hexane and ethyl acetate soluble fractionates showed significant cytotoxic activities with median lethal concentrations (LC 50 ) 19.95 µg/mL and 12.88µg/mL while LC 50 for the vincristine sulphate was 10.96 µg/mL. Conclusion: This study shows that the leaves of Sanchezia speciosa Hook. f may have potentials in control of carcinogenesis in the field of pharmacology.

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Extraction of secondary metabolites from plant material: A review

Cited by 109 publications

References 26 publications

Metabolomics — the link between genotypes and phenotypes

Metabolomics — the link between genotypes and phenotypes

Sinapinic and protocatechuic acids found in rapeseed: isolation, characterisation and potential benefits for human health as functional food ingredients

Preliminary phytochemical screening and cytotoxic potentials from leaves of Sanchezia speciosa Hook.f

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