Extraction of Phenolic Compounds by Supercritical Fluid Extraction

Yaqoob, Mudasir; Aggarwal, Poonam; Purandare, Neha

doi:10.1007/978-3-030-44984-1_6

Cited by 5 publications

(3 citation statements)

References 65 publications

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“…2) results from the hydrolysis of gluconasturtiin by the action of myrosinase. The final product is an ITC with a phenylethyl radical attached to a nitrogen atom [ [8,16]. However, the physiological properties of PEITC are not reduced only to those that it exerts in the source of origin.…”

Section: Phenylethyl Isothiocyanatementioning

confidence: 99%

“…As a chemopreventive and antioxidant agent, PEITC may modulate the unregulated ROS concentration in cells, activating antioxidant defence mechanisms, such as increasing detox enzymes' expression to decline the ROS to basal levels necessary for cellular metabolism [16,21]. However, PEITC acts simultaneously as an oxidiser, since it has a high capacity to generate ROS and induce oxidative damage in tumour cells, so they become more sensitive to it, making it "selective" for this type of cells [12].…”

Section: Antioxidant Actionmentioning

confidence: 99%

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Phenethyl Isothiocyanate, a Bioactive Agent for Gastrointestinal Health: A Review

Coscueta¹,

Sousa²,

Reis³

et al. 2021

Preprint

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The incidence of gastrointestinal diseases (cancer in particular) has increased progressively with considerable morbidity, mortality, and a high economic impact on the healthcare system. Dietary intake of natural bioactive phytochemicals showed to have cancer-preventing and therapeutic effects. This includes the cruciferous vegetable derivative phenethyl isothiocyanate (PEITC), a bioactive compound from watercress. PEITC antioxidant, anti-inflammatory and anti-cancer properties are of particular importance. This review summarizes the current knowledge on the role of PEITC as a potential natural nutraceutical or an adjuvant against oxidative/inflammatory-related disorders in the gastrointestinal tract. We also discuss the safe and recommended dose of PEITC. Besides, we establish a framework to guide the research and development of sustainable methodologies for obtaining and stabilizing this natural nutraceutical for industrial use. This is a topic that still needs more scientific development, but with the potential to lead to a viable strategy in the prevention of cancer and other associated diseases of the gastrointestinal tract.

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Section: Phenylethyl Isothiocyanatementioning

confidence: 99%

Section: Antioxidant Actionmentioning

confidence: 99%

Phenethyl Isothiocyanate, a Bioactive Agent for Gastrointestinal Health: A Review

Coscueta¹,

Sousa²,

Reis³

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…[1,2] Enzymatic hydrolysis of sulfur and nitrogen in glucosinolates (GSLs) by the action of the myrosinase enzyme is responsible for releasing the PEITC. [2,3] Besides, the hydrolysis of GSLs compounds and the production of PEITC are considered crucial defense mechanisms against climate change, stress, and even pathogens such as insects, bacteria, and fungi. [2] PEITC possesses significant bioactive properties such as anti-inflammatory, antioxidant, antimicrobial, and anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights

M. Ezzat,

M. Merghany,

M. Abdel Baki

et al. 2024

Molecular Nutrition Food Res

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Phenethyl isothiocyanate (PEITC), a compound derived from cruciferous vegetables, has garnered attention for its anticancer properties. This review synthesizes existing research on PEITC, focusing on its mechanisms of action in combatting cancer. PEITC has been found to be effective against various cancer types, such as breast, prostate, lung, colon, and pancreatic cancers. Its anticancer activities are mediated through several mechanisms, including the induction of apoptosis (programmed cell death), inhibition of cell proliferation, suppression of angiogenesis (formation of new blood vessels that feed tumors), and reduction of metastasis (spread of cancer cells to new areas). PEITC targets crucial cellular signaling pathways involved in cancer progression, notably the Nuclear Factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB), Protein Kinase B (Akt), and Mitogen‐Activated Protein Kinase (MAPK) pathways. These findings suggest PEITC's potential as a therapeutic agent against cancer. However, further research is necessary to determine the optimal dosage, understand its bioavailability, and assess potential side effects. This will be crucial for developing PEITC‐based treatments that are both effective and safe for clinical use in cancer therapy.

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