Extraction of Octamethylcyclotetrasiloxane and Its Metabolites from Biological Matrices

Varaprath, Sudarsanan; Salyers, Kevin L.; Plotzke, Kathleen P.; Nanavati, Shrenik M.

doi:10.1006/abio.1997.2475

Cited by 46 publications

(46 citation statements)

References 13 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the mass spectrometric studies were run for a mixture of products, they correspond well to the results obtained for analogous systems of OH containing silanes [37,38].…”

Section: Methodssupporting

confidence: 62%

See 1 more Smart Citation

Investigation of hydrolysis and condensation of methyltriethoxysilane in aqueous systems

2013

View full text Add to dashboard Cite

“…Although the mass spectrometric studies were run for a mixture of products, they correspond well to the results obtained for analogous systems of OH containing silanes [37,38].…”

Section: Methodssupporting

confidence: 62%

“…Our model studies have shown that the persistent presence of hydroxyl groups would enable the forming resin to react with OH groups present on the surface of the soil particles [37] as shown by us [22] (Scheme 10). Silanol groups are more stable in water emulsion than in organic solvent due to extensive formation of hydrogen bonds [39,40].…”

Section: Methodsmentioning

confidence: 82%

Investigation of hydrolysis and condensation of methyltriethoxysilane in aqueous systems

2013

View full text Add to dashboard Cite

“…Exhaled air samples were collected before, immediately after exposure, and at 1 and 6 hr after exposure. D 4 was extracted from plasma samples with tetrahydrofuran and the D 4 analysis was performed using gas chromatography-mass spectrometry analysis as described elsewhere (21).…”

Section: Model Validation Rat Inhalation Modelmentioning

confidence: 99%

Bioavailability of Octamethylcyclotetrasiloxane (D 4 ) after Exposure to Silicones by Inhalation and Implantation

Luu¹,

Hutter²

2001

Environmental Health Perspectives

View full text Add to dashboard Cite

“…It is known that small amounts of water in injected samples can readily generate D 4 by high-temperature hydrolysis of polymeric silicone materials used in septa and column stationary phases [36,38]. THF extracts from reagent blanks appeared to contain small amounts of D 4 .…”

Section: Skin Distribution Studymentioning

confidence: 99%

“…D 4 was extracted from the epidermis, dermis and adipose tissue with tetrahydrofuran (99.5% THF; Aldrich Chemical Co.) [36]. The tissue samples were weighed in 7-ml glass extraction vials.…”

Section: Skin Distribution Studymentioning

confidence: 99%

Percutaneous Absorption Studies of Octamethylcyclotetrasiloxane Using the Human Skin/Nude Mouse Model

Zaręba

Gelein²,

Morrow³

et al. 2002

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Octamethylcyclotetrasiloxane (D₄) has been used for more than 40 years in industrial applications and consumer products, including the personal care industry. D₄ possesses many properties suitable for personal care products, such as low surface tension, water repellency, and thermal and chemical stability. The skin is a major route of exposure to D₄for humans. The main objective of this study was to evaluate the percutaneous absorption of neat D₄ in human skin using the human skin/nude mouse model. This information is needed to aid in assessing potential risks associated with the intended use of D₄. To determine whether D₄ accumulates in adipose tissue of the skin, the distribution of D₄ in human skin layers following application of neat D₄ was also evaluated. In this study, a mean of 1.09 ± 0.46% of the applied dose was absorbed by the animal under semioccluded conditions. Only about 0.02% of the applied dose remained in the skin after 24 h of exposure (or 72 h after application). The majority (94.59 ± 12.28%) of the dose evaporated from the site. Excretion in the volatile trap (or expired volatiles) accounted for 42% of the radioactivity that was absorbed, while 49% were excreted in the urine and feces. Despite the lipophilic properties of D₄, a significant accumulation of D₄ in adipose tissue of the skin was not observed 24 h following application to the surface of the skin. The small amount of D₄ detected in the skin was distributed mainly in the epidermis (61%), with lower amounts in the dermis (29%) and subcutaneous adipose tissue (10%). Dermal absorption studies using human skin transplanted onto nude mice showed that this model could be successfully applied for in vivo percutaneous absorption studies of D₄, and presumably of other cyclic siloxanes. The fraction of the percutaneous dose of D₄ absorbed in this model was found to be consistent with results reported by others using different experimental approaches.

show abstract

Extraction of Octamethylcyclotetrasiloxane and Its Metabolites from Biological Matrices

Cited by 46 publications

References 13 publications

Investigation of hydrolysis and condensation of methyltriethoxysilane in aqueous systems

Investigation of hydrolysis and condensation of methyltriethoxysilane in aqueous systems

Bioavailability of Octamethylcyclotetrasiloxane (D 4 ) after Exposure to Silicones by Inhalation and Implantation

Percutaneous Absorption Studies of Octamethylcyclotetrasiloxane Using the Human Skin/Nude Mouse Model

Contact Info

Product

Resources

About