Extraction of major alkaloids from poppy straw with near-critical mixtures of carbon dioxide and polar modifiers

Janicot, J.L.; Caude, M.; Rosset, R.; Veuthey, Jean‐Luc

doi:10.1016/s0021-9673(01)93083-3

Cited by 28 publications

(5 citation statements)

References 18 publications

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“…Antitumour active pyrrolizidine alkaloids were extracted with ethanol-modified supercritical carbon dioxide from crushed seeds of Crotalaria spectabilis (Schaeffer et al, 1989) and from two kinds of Senecio species (Bicchi et al, 1991). Poppy straw alkaloids (thebaine, codeine and morphine) have been extracted using a subcritical mixture of carbon dioxide with polar modifier (Janicot et al, 1990). Volatile components from three kinds of medicinal plants (frankincense, myrrh (both from the Olive family) and Evodia rutaecarpa) that are used in Chinese herbal medicine were separated and determined by SPE followed by gas chromatography-mass spectrometric (GS/MS) analysis by Ma et al (1991).…”

Section: Introductionmentioning

confidence: 99%

Supercritical fluid extraction of lignans from seeds and leaves ofSchizandra chinensis

et al. 1997

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Supercritical carbon dioxide was used to extract lignans from seeds and leaves of Schizandra chinensis (Turcz.) Baill. Kinetics of the extraction was found to be controlled by intra‐particle diffusion of lignans. The extraction yields were approximately 96% of lignans from seeds and about 26% from leaves, both yields being based on the total lignan content determined from two successive Soxhlet extractions with petroleum ether and methanol. © 1997 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Supercritical fluid extraction of lignans from seeds and leaves ofSchizandra chinensis

et al. 1997

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“…The addition of H 2 O increases the polarity of the mixture relative to methanol alone . Enhanced-fluidity liquid methanol/H 2 O/CO 2 mixtures were successfully applied to chromatographic separations. , Liquid methanol/H 2 O/CO 2 mixtures were previously used for the extraction of morphinic alkaloids from poppy straw, and methanol/H 2 O/triethylamine/CO 2 mixtures were utilized for the recovery of morphinic alkaloids from urine with good results …”

Section: Resultsmentioning

confidence: 99%

Comparison of Supercritical Fluids and Enhanced-Fluidity Liquids for the Extraction of Phenolic Pollutants from House Dust

Reighard

Olesik

1996

Anal. Chem.

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The supercritical fluid extraction (SFE) of polar analytes and/or complex and adsorptive matrices is often difficult. The use of enhanced-fluidity liquid extraction (EFLE) as an alternative is investigated herein. Enhanced-fluidity liquids are prepared by combining a large proportion of an associated organic solvent with a low-viscosity liquid, such as CO2. The extraction of 11 phenolic and nitroaromatic pollutants from house dust was tested with Soxhlet extraction, SFE, and EFLE. The addition of methanol to CO2 greatly improved the extraction rate compared to CO2 alone. A 20/80 mol % methanol/CO2 mixture at enhanced-fluidity liquid conditions yielded statistically higher recoveries than other methanol/CO2 mixtures for the majority of analytes. Enhanced-fluidity liquid methanol/H2O/CO2 mixtures showed gains in extraction yields relative to methanol/CO2 mixtures. For example, recoveries of all 11 analytes averaged 50% with 10/90 mol % methanol/CO2, 61% with 20/80 mol % methanol/CO2, and 69% with 32.1/7.9/60.0 mol % methanol/H2O/CO2. The addition of methanol or H2O directly to the sample as static modifier was also tested; methanol yielded higher recoveries, although the results were 10−20% lower than those obtained with methanol/CO2 and methanol/H2O/CO2 mixtures. Recoveries by SFE and EFLE at various conditions were comparable to or better than Soxhlet extraction for all of the analytes studied.

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“…The concentration steps in SFE are greatly simplified since the supercritical fluid such as carbon dioxide is easily removed from the extract by depressurization, and this presents another advantage of SFE compared to solvent extraction. SFE has recently been successfully applied to a range of natural products, such as spices [18][19][20], herbal plants [21,22], paper [23], wood [23,24], poppy straw [25], coffee [26], oilseeds [27], lemons [28], aromatic plants [29], and vegetable oils [30,31]. The small sample requirement of SFE has been demonstrated by Elisabeth et al in the extraction of caffeine from 2 g of coffee powder using supercritical carbon dioxide.…”

Section: Introductionmentioning

confidence: 99%

Supercritical fluid extraction and capillary gas chromatography of the rhizomes of Z. zerumbet

Ahmad

Sirat

Sanagi

et al. 1994

J Microcolumn Separations

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Abstract. Supercritical carbon dioxide at 60°C and 200 bar has been used to extract the nonpolar components of the dried rhizomes of Zingiber zerumbet. The extract could be fractionated by placing an on-line silica column before the pressure relief valve. The extracts were analyzed using capillary GC and GC-MS. This technique provides an effective means of sample preparation and a relatively fast way of determining the constituents of plant materials.

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Extraction of major alkaloids from poppy straw with near-critical mixtures of carbon dioxide and polar modifiers

Cited by 28 publications

References 18 publications

Supercritical fluid extraction of lignans from seeds and leaves ofSchizandra chinensis

Supercritical fluid extraction of lignans from seeds and leaves ofSchizandra chinensis

Comparison of Supercritical Fluids and Enhanced-Fluidity Liquids for the Extraction of Phenolic Pollutants from House Dust

Supercritical fluid extraction and capillary gas chromatography of the rhizomes of Z. zerumbet

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