Extraction of Alkaloids from Coptidis Rhizoma via Betaine‐Based Deep Eutectic Solvents

Li, Yuanbin; Hsieh, Yun‐Hao; Pan, Zuchen; Zhang, Ling; Wang, Binshen; Zhang, Jiaheng

doi:10.1002/slct.202000865

Cited by 16 publications

(14 citation statements)

References 41 publications

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“…171,172 In addition, betaine-based DES with low viscosity has been employed as a selective medium to concentrate ephendrine from coptidis. 173 It could be conclusive from these investigations that higher viscosity occurs in low solubility with lesser gaps for hydrogen bonding of product. This has a negative effect on the product being selectively soluble in DES.…”

Section: Acs Sustainablementioning

confidence: 87%

Sustainable and Green Engineering Insights on Deep Eutectic Solvents toward the Extraction of Nutraceuticals

Balaraman

Rangabhashiyam

Rangarajan

et al. 2021

ACS Sustainable Chem. Eng.

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Deep eutectic solvents (DES) hold promising potential in the selective purification of bioactive molecules from various complex sources. Although they are increasingly considered as a biocompatible extraction medium, adding the task-specific functionality, which makes DES distinctive for the selective extraction of compounds, requires appropriate tailoring of their physical properties. This critical review investigates the influential physical properties of deep eutectic solvents and their effect on various sustainable extraction methodsincluding both solid–liquid and liquid–liquidfor the separation of nutraceuticals. Various methods by which DES are employed as solvents, cosolvents, or as adjuvants in different extraction systems are compared in terms of their efficiency and selectivity. Furthermore, the correspondence between the type of DES and the nature of target nutraceuticals to be extracted is also discussed. The Review highlights the key achievements and future prospects of employing DES along with the lacunae in the current investigations and proposed various approaches for sustainable applications.

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Section: Acs Sustainablementioning

confidence: 87%

Sustainable and Green Engineering Insights on Deep Eutectic Solvents toward the Extraction of Nutraceuticals

Balaraman

Rangabhashiyam

Rangarajan

et al. 2021

ACS Sustainable Chem. Eng.

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“…They were recognized as a promising solvent in extraction and separation processes [ 23 ]. Until now, DESs have been widely used in the extraction of bioactive compounds in Chinese herbal medicine, such as polyphenols [ 24 , 25 , 26 ], flavonoids [ 27 , 28 ] and alkaloids [ 29 , 30 ]. DESs are mostly hydrophilic, and hydrophobic DESs were first reported in 2015 [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Cai

et al. 2021

Molecules

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Deep eutectic solvents (DESs) are considered as efficient and green solvents for the extraction of bioactive compounds from medicinal plants. In this work, a novel method of DES-based ultrasound-assisted extraction of bioactive compounds from Baphicacanthus cusia leaves (BCL) was established. Systematic screening and the morphology of the original and treated BCL were observed with scanning electron microscopy to determine the extraction efficiency of different solvents. The extraction conditions were optimized by Box–Behnken design (BBD) tests and the optimal extraction conditions were as follows: lactic acid/L-menthol ratio of 5: 2 (mol/mol), solid–liquid ratio of 80.0 mL/g and temperature of 60.5 °C. The extraction yields of tryptanthrin, indigo and indirubin reached 0.356, 1.744 and 0.562 mg/g, respectively. The results of a 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging activity test indicated the feasibility of DESs in the extraction of bioactive compounds. This study indicated that L-menthol/lactic acid was a green and efficient solvent for the extraction of bioactive compounds from BCL, and DES-based ultrasound-assisted extraction could be used as an effective application strategy for the extraction of bioactive compounds from medicinal plants.

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“…[33]. For the extraction of these alkaloids from the rhizomes of Coptis chinensis Franch., betaine-based NADES were used [32]. In this case, the combination with organic acid and water (1 : 1 : 1) also performed best, particularly when using citric acid.…”

Section: Resultsmentioning

confidence: 99%

Pressurized Natural Deep Eutectic Solvent Extraction of Galanthamine and Related Alkaloids from Narcissus pseudonarcissus

et al. 2022

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The isolation of a compound from a natural source involves many organic and mostly toxic solvents for extraction and purification. Natural Deep Eutectic Solvents (NADES) have been shown to be efficient options for the extraction of natural products. They have the advantage of being composed of abundantly available common primary metabolites, being non-toxic and environmentally safe solvents. The aim of this study was to develop a NADES-based extraction method for galanthamine, an important therapeutic agent for the treatment of Alzheimer’s disease. This alkaloid can be produced by synthesis or by extraction from Narcissus bulbs. To develop an efficient extraction method a number of different NADES was first tested for their solubilization capacity of the galanthamine bromide salt. Promising results were obtained for ionic liquids, as well as some amphoteric and acidic NADES. In a two-cycle extraction process the best solvents were tested for the extraction of galanthamine from bulbs. The ionic liquids produced poor yields, and the best results were obtained with some acid and sugar mixtures, among which malic acid – sucrose – water (1:1:5) proved to be the best, showing similar yields to that of the exhaustive Soxhlet extraction with methanol. Furthermore, the NADES was more selective for galanthamine.

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Extraction of Alkaloids from Coptidis Rhizoma via Betaine‐Based Deep Eutectic Solvents

Cited by 16 publications

References 41 publications

Sustainable and Green Engineering Insights on Deep Eutectic Solvents toward the Extraction of Nutraceuticals

Sustainable and Green Engineering Insights on Deep Eutectic Solvents toward the Extraction of Nutraceuticals

Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Pressurized Natural Deep Eutectic Solvent Extraction of Galanthamine and Related Alkaloids from Narcissus pseudonarcissus

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