Extraction and Refinement Strategy for detection of autism in 18‐month‐olds: a guarantee of higher sensitivity and specificity in the process of mass screening

Honda, Hideo; Shimizu, Yasuo; Nitto, Yukari; Imai, Miho; Ozawa, Takeshi; Iwasa, Mitsuaki; Shiga, Keiko; Hira, Tomoko

doi:10.1111/j.1469-7610.2009.02055.x

Cited by 26 publications

(18 citation statements)

References 22 publications

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“…Other countries have adopted similar strategies, combining routine child-health surveillance with a standardised method. In Japan, the young autism and other developmental disorders checkup tool (YACHT) is administered by public health nurses to children aged 18 and 24 months 17. Wong and colleagues18 have modified the checklist for autism in toddlers (CHAT) for use in China, with a two-stage screening strategy in CHAT-23, incorporating a questionnaire and a direct observation stage that has more sensitivity and specificity than does CHAT.…”

Section: Clinical Characteristics and Screeningmentioning

confidence: 99%

“…This assessment might be done through community resources (eg, early intervention staff, educators, psychologists, or speech pathologists), educational agencies, or local developmental clinicians. Reviews of early identification and screening are available 15,17,19. If concerns that a child has autism spectrum disorder are validated, comprehensive diagnostic assessment is needed (figure 1).…”

Section: Assessmentmentioning

confidence: 99%

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Autism

2009

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Autism spectrum disorders are characterised by severe deficits in socialisation, communication, and repetitive or unusual behaviours. Increases over time in the frequency of these disorders (to present rates of about 60 cases per 10 000 children) might be attributable to factors such as new administrative classifications, policy and practice changes, and increased awareness. Surveillance and screening strategies for early identification could enable early treatment and improved outcomes. Autism spectrum disorders are highly genetic and multifactorial, with many risk factors acting together. Genes that affect synaptic maturation are implicated, resulting in neurobiological theories focusing on connectivity and neural effects of gene expression. Several treatments might address core and comorbid symptoms. However, not all treatments have been adequately studied. Improved strategies for early identification with phenotypic characteristics and biological markers (eg, electrophysiological changes) might hopefully improve effectiveness of treatment. Further knowledge about early identification, neurobiology of autism, effective treatments, and the effect of this disorder on families is needed.

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Section: Clinical Characteristics and Screeningmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

Autism

2009

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“…M-CHAT and FYI), they did not calculate the estimated sensitivity for an unselected sample. Instead, they calculated sensitivity and specificity based on cases that were already diagnosed or included high-risk children, thereby increasing the prevalence of ASD (Honda et al, 2009) and thereby possible overestimation of the PPV and NPV. Other screeners that estimated the predictive validity based on a general population study yielded lower sensitivity (e.g.…”

Section: Discussionmentioning

confidence: 99%

Screening for Autism Spectrum Disorders in Flemish Day-Care Centres with the Checklist for Early Signs of Developmental Disorders

Dereu

Warreyn

Raymaekers

et al. 2010

J Autism Dev Disord

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“…However, as the prevalence of suspected ASD in our study (13.5%) was equivalent to the prevalence of suspected ASD among 18-month-old toddlers who were identified for follow-up in a previous study (i.e. 14.3%) [37], the assessment of suspected ASD is considered acceptable. Second, information on paternal characteristics such as age or occupation was not assessed, although previous studies reported that they might be independently associated with ASD [38], [39].…”

Section: Discussionmentioning

confidence: 40%

Are Maternal Social Networks and Perceptions of Trust Associated with Suspected Autism Spectrum Disorder in Offspring? A Population-Based Study in Japan

Fujiwara

Kawachi

2014

PLoS ONE

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ObjectiveTo investigate the associations of maternal social networks and perceptions of trust with the prevalence of suspected autism spectrum disorders in 18-month-old offspring in Japan.MethodsQuestionnaires included measurements of maternal social networks (number of relatives or friends they could call upon for assistance), maternal perceptions of trust, mutual assistance (i.e. individual measures of “cognitive social capital”), and social participation (i.e. individual measures of “structural social capital”) as well as the Modified Checklist for Autism in Toddlers to detect suspected autism spectrum disorder (ASD). These tools were mailed to all families with 18-month-old toddlers in Chiba, a city near Tokyo (N = 6061; response rate: 64%). The association between social capital or social network indicators and suspected ASD were analyzed, adjusted for covariates by logistic regression analysis.ResultsLow maternal social trust was found to be significantly positively associated with suspected ASD in toddlers compared with high maternal social trust (adjusted odds ratio [OR]: 1.82, 95% confidence interval [CI]: 1.38 to 2.40); mutual aid was also significantly positively related (low vs. high: OR, 1.82, 95% CI: 1.38 to 2.40). However, maternal community participation showed U-shape association with suspected ASD of offspring. Maternal social network showed consistent inverse associations with suspected ASD of offspring, regardless of the type of social connection (e.g., relatives, neighbors, or friends living outside of their neighborhood).ConclusionsMothers' cognitive social capital and social networks, but not structural social capital, might be associated with suspected ASD in offspring.

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Extraction and Refinement Strategy for detection of autism in 18‐month‐olds: a guarantee of higher sensitivity and specificity in the process of mass screening

Abstract: An extraction and refinement methodology utilizing child health surveillance programs achieve high efficacy for early detection of autism.

Cited by 26 publications

References 22 publications

Autism

Autism

Screening for Autism Spectrum Disorders in Flemish Day-Care Centres with the Checklist for Early Signs of Developmental Disorders

Are Maternal Social Networks and Perceptions of Trust Associated with Suspected Autism Spectrum Disorder in Offspring? A Population-Based Study in Japan

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