Extraction and Recrystallization of Mesoionic Pyrimidinium Betaines

Fatiha, Malki; Touati, Abdelkader; Moulay, Saâd

doi:10.7763/ijcea.2014.v5.369

Cited by 7 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pyrimidinium betaines 1-4 were synthesized and characterized as described earlier [10], [11]. Their antioxidant behavior was evaluated in vitro by three different tests: DPPH test, measurement of reducing power, and β-carotene bleaching technique.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Antioxidant Activity of Some Mesoionic Pyrimidinium Betaines by Three Different Methods

Malki¹,

Touati²,

Moulay³

et al. 2016

IJCEA

View full text Add to dashboard Cite

A series of mesoionic pyrimidinium betaines were synthesized and tested in vitro for their antioxidant activity using three tests: 2,2-diphenyl-1-picrylhydrazil (DPPH) free radical scavenging, Ferric Reducing Antioxidant Power (FRAP) and bleaching of β-carotene. The results indicated that pyrimidinium betaines possess antioxidant properties with three methods. In the DPPH assay, the monocyclic pyrimidinium betaine showed the highest activity with an IC 50 value of 300 µg/mL. The pyrimidinium betaines also revealed a reducing power lower than that of the control antioxidants, and the monocyclic pyrimidinium betaine was the most active one. In the β-carotene bleaching test, the oxidation of linoleic acid was inhibited by all the betaines. The bicyclic one showed the greatest inhibitory activity of the oxidation of linoleic acid with a relative antioxidant activity (RAA) of 90%, an activity higher than that of the reference antioxidant α-tocopherol (41%). It was found that the antioxidant efficacy increased with increasing concentration of betaine and depended on the nature of the substituent on the pyrimidine ring.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Three pyrimidinium betaines: two bicyclics 1, 2, one monocyclic 3, and one with fatty chain alkyl 4, were prepared from amine derivatives and malonic esters by the reported procedures [11]- [13]. Their chemical structures are represented in…”

Section: B Synthesismentioning

confidence: 99%

Evaluation of Antioxidant Activity of Some Mesoionic Pyrimidinium Betaines by Three Different Methods

Malki¹,

Touati²,

Moulay³

et al. 2016

IJCEA

View full text Add to dashboard Cite

show abstract

“…In further attempts, varying the volume ratio of the eluting system cyclohexane/ethyl acetate failed to separate the desired betaine 7. However, liquid-liquid extraction allowed the isolation of the betaine in 37% yield [12]. From TLC plate depicted in Fig.…”

Section: Resultsmentioning

confidence: 99%

Use of Column Chromatography for Quantitative Isolation of Mesoionic Pyrimidinium Betaines

2015

IJRCMCE

View full text Add to dashboard Cite

Three mesoionic pyrimidinium betaines were synthesized and isolated using column chromatography. Such a technique was of a great help as far as a good isolation of the desired betaine from the synthesis crude product, being a mixture of several compounds, was not straightforward. Thin layer chromatograhy (TLC) analyses put up the better eluting system, in terms of retention factor, for a relatively quantitative separation of a pure betaine. Spectral analyses revealed the high purity of the isolated betaines.

show abstract

“…Their chemical structures are represented in Figure 1. Details of the synthesis and structural characterization of the compounds 1-3 can be found in Malki et al [19][20][21] 1 R 1 = R 2 = H 3 R= R 1 = R 2 = C 6 H 5 2 R 1 = H, R 2 = C 6 H 5 Figure 1 Structures of studied compounds DPPH radical scavenging assay: DPPH has been widely used for measurement of free radical scavenging ability of antioxidants. 22 This method is based on the reduction of an alcoholic DPPH solution in the presence of a hydrogen-donating antioxidant.…”

Section: Introductionmentioning

confidence: 99%

Study of antioxidant activity of pyrimidinium betaines by DPPH radical scavenging method

Fatiha¹,

Touati²

2019

JAPLR

View full text Add to dashboard Cite

Chemicals and all solvents were of analytical grade and were purchased from Sigma-Aldrich, Merck, Prolabo and Biochem. In this study, pyrimidinium betaines 1-3 dissolved in ethanol were tested at concentrations 0-500µg/mL. Butylated hydroxyanisole (BHA), Butylated hydroxy toluene (BHT) and ascorbic acid (vitamin C) used as control standard antioxidants dissolved in ethanol were tested at concentrations 0-15µg/mL. Methods Synthesis of the compounds: The compounds including bicyclic pyrimidinium betaines: 1, 2 and monocyclic 3 were synthesized from amine derivatives and malonic esters by the reported procedures 17-20

show abstract

Extraction and Recrystallization of Mesoionic Pyrimidinium Betaines

Cited by 7 publications

References 16 publications

Evaluation of Antioxidant Activity of Some Mesoionic Pyrimidinium Betaines by Three Different Methods

Evaluation of Antioxidant Activity of Some Mesoionic Pyrimidinium Betaines by Three Different Methods

Use of Column Chromatography for Quantitative Isolation of Mesoionic Pyrimidinium Betaines

Study of antioxidant activity of pyrimidinium betaines by DPPH radical scavenging method

Contact Info

Product

Resources

About