Extract of Moringa oleifera leaves ameliorates streptozotocin-induced Diabetes mellitus in adult rats

Yassa, Hanan Dawood; Tohamy, Adel F.

doi:10.1016/j.acthis.2014.02.002

Cited by 121 publications

(92 citation statements)

References 46 publications

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“…This indicates the potential insulinotropic effect of BCP. Similar results were observed in streptozotocin-induced diabetic albino rats treated with aqueous extract of Moringa oleifera leaves (Yassa and Tohamy, 2014).…”

Section: Immunohistochemistrysupporting

confidence: 82%

“…1) is a natural bicyclic sesquiterpene, found in large amounts in the essential oils of curry, cloves, cinnamon, black pepper, cannabis, guava and moringa (Liu et al, 2013;Yassa and Tohamy, 2014). BCP, a cannabinoid receptor-2 (CB2) agonist is used as a dietary cannabinoid approved as a food additive substance by the Food and Drug Administration and which exerts antioxidant, anti-peroxidative, anti-inflammatory, hepatoprotective and neuroprotective properties (Calleja et al, 2013;Horvath et al, 2012;Bento et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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β-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats

Basha

Sankaranarayanan

2014

Acta Histochemica

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Section: Immunohistochemistrysupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

β-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats

Basha

Sankaranarayanan

2014

Acta Histochemica

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“…Conventionally, almost all parts of these plants (the whole plant, the aerial parts and/or the roots) have been used on an extensive basis, either as food or medicinal components (Yang, 2014). The leaves are particularly rich in protein, essential amino acids and other micronutrients (Adedapo, Jimoh, & Afolayan, 2011;Moyo, Masika, Hugo, & Muchenje, 2011;Yassa & Tohamy, 2014). The extracts of both plants have been identified to possess several functional properties, such as antioxidant, antihypertensive, antimicrobial, antifungal, antiulcer, antitumor and anticancer activities (Bartolome et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

In vitro antimicrobial activities of Bidens pilosa and Moringa oleifera leaf extracts and their effects on ground beef quality during cold storage

Falowo

Muchenje

Hugo

et al. 2016

CyTA - Journal of Food

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This study determined the activities of Bidens pilosa and Moringa oleifera leaf extracts on microbial count of ground beef during 6-day cold storage. Fresh ground beef sample was treated with butylated hydroxytoluene (BHT) (0.2 g/kg), M. oleifera (ML, 1 g/kg) and B. pilosa (BP, 1 g/kg) leaf extracts and compared with the control. The result of the phytochemical contents revealed that ML extract had higher phenolic and flavonoid contents than BP extract (p > 0.05). The antibacterial assay of the extracts revealed an appreciable broad-spectrum activity against tested bacteria with minimum inhibitory concentrations between 0.6 and 10.0 mg/mL. Addition of ML leaf extract to ground beef sample lowered total viable and lactic acid bacteria (p < 0.05) counts than control and BHT treatments at day 3 of storage. These results suggest that ML leaf extract could be used as potential sources of natural antimicrobial agent in meat products.Actividades antimicrobianas in vitro de extractos de hoja de Bidens pilosa y Moringa oleifera y sus efectos en la calidad de ternera triturada durante el almacenamiento en frío RESUMEN Este estudio determinó las actividades de los extractos de hoja de B. pilosa y M. oleifera en los recuentos microbianos de ternera triturada durante 6 días de almacenamiento en frío. Se trató con BHT una muestra fresca de ternera triturada (0,2 g/kg) y extractos de hoja M. oleifera (ML, 1 g/kg) y B. pilosa (BP, 1 g/kg), entonces estos fueron contrastados con la muestra control. Los resultados de los contenidos fitoquímicos revelaron que el extracto de ML tenía un mayor contenido fenólico y de flavonoides en comparación con el extracto de BP (p > 0,05). El ensayo antibacteriano de los extractos reveló una apreciable actividad de amplio espectro frente a las bacterias examinadas con concentraciones inhibitorias mínimas utilizando rangos entre 0,6 y 10,0 mg/mL. La adición de extracto de hoja de ML a la muestra de ternera triturada disminuyó el recuento total viable de bacteria ácido-láctica (p < 0,05) más que en la muestra control y los tratamientos de BHT en tercer día de almacenamiento. Estos resultados sugieren que el extracto de hoja de ML podría ser utilizado como fuente potencial de agente antimicrobiano natural en los productos cárnicos. ARTICLE HISTORY

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“…Thiobarbituric acid reactive substances (TBARS) and lipid peroxide (LOOH) are the markers of lipid peroxidation. It is an autocatalytic reaction which leads to oxidative destruction of cellular membranes, resulting in the production of toxic free radicals such as, superoxide radicals, H 2 O 2 and hydroxyl radicals (Yassa and Tohamy, 2014). Measurement of TBARS was used as an index of lipid peroxidation and it helps to assess the extent of tissue damage (Jangale et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of betanin against streptozotocin - nicotinamide induced liver, kidney and pancreas damage by attenuating lipid byproducts and improving renal biomarkers in Wistar rats

2017

Int. J. Adv. Res. Biol. Sci

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Objective: We attempted to determine whether betanin (from natural pigments) that has antioxidant properties would be protective against diabetes induced by streptozotocin-nicotinamide in adult Wistar rats. Methods: Diabetes was induced by a single intraperitoneal (i.p.) injection of streptozotocin (STZ; 45 mg/kg b.w.) dissolved in 0.1 M citrate buffer (pH 4.5) 15 min after the i.p. administration of nicotinamide (NA; 110 mg/kg b.w.). Experimental rats were administered betanin at the dose of 20 mg/kg b.w. and glibenclamide (600 µg/kg b.w.) once a day for 30 days. Results: Untreated diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), urea, uric acid, creatinine and decreased levels of plasma insulin. Co-administration with betanin to the diabetic rats showed improved levels of plasma glucose, insulin, lipid peroxidation byproducts (LPO) and kidney biomarkers enzymes when compared to untreated diabetic rats. Moreover, histological study of kidney revealed the effect of betanin in diabetic rats. Similar kind of experimental results were obtained in glibenclamide treated diabetic rats. Conclusion: According to our current study, betanin had a beneficial role against the diabetes induced by STZ-NA in rats.

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Extract of Moringa oleifera leaves ameliorates streptozotocin-induced Diabetes mellitus in adult rats

Cited by 121 publications

References 46 publications

β-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats

β-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats

In vitro antimicrobial activities of Bidens pilosa and Moringa oleifera leaf extracts and their effects on ground beef quality during cold storage

Protective effect of betanin against streptozotocin - nicotinamide induced liver, kidney and pancreas damage by attenuating lipid byproducts and improving renal biomarkers in Wistar rats

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