Extract of ice plant (<i>Mesembryanthemum crystallinum</i>) ameliorates hyperglycemia and modulates the gut microbiota composition in type 2 diabetic Goto-Kakizaki rats

Zhang, Chengcheng; Wu, Weicheng; Xin, Xiaoting; Li, Xiaoqiong; Liu, Daqun

doi:10.1039/c9fo00119k

Cited by 28 publications

(29 citation statements)

References 38 publications

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“…In this study, we demonstrated that the bacterial diversity which decreased in ZDF rats was restored by LLKL treatment. In addition, we noted that Firmicutes and Bacteroidetes were the two most abundant populations in ZDF rats, which was consistent with previous studies 44,45 . Importantly, compared with the NC group, the gut microbiome in the MOD group showed a reduced abundance of Bacteroidetes and an increased proportion of Firmicutes , which resulted in an increase Firmicutes / Bacteroidetes ratio, whereas LLKL_H and LLKL_M treatments sufficiently reduced these differences.…”

Section: Discussionsupporting

confidence: 91%

“…Firmicutes and Bacteroidetes were the two most abundant populations in ZDF rats, which was consistent with previous studies. 44,45 Importantly, compared with the NC group, the gut microbiome in the MOD group showed a reduced abundance of Bacteroidetes and an increased proportion of Firmicutes, which resulted in an increase but consistent with other reports. 48,49 This evidence suggests that LLKL promotes the balance of gut microbiota in ZDF rats.…”

Section: Discussionsupporting

confidence: 88%

“…For example, probiotics have been identified as effective adjuvants to improve insulin resistance due to their gut microbiota regulation function 43 . Recent studies reported an increased ratio of Firmicutes to Bacteroidetes in both T2DM animal model and patients, which was positively correlated with FBG level and the inflammation status 44‐46 . Although the gut microbiota plays an important role in diabetes, the effect of LLKL on gut microbiota in ZDF rats is still unknown.…”

Section: Discussionmentioning

confidence: 99%

“…with FBG level and the inflammation status. [44][45][46] Although the gut microbiota plays an important role in diabetes, the effect of LLKL on gut microbiota in ZDF rats is still unknown. In this study, we demonstrated that the bacterial diversity which decreased in ZDF rats was restored by LLKL treatment.…”

Section: Discussionmentioning

confidence: 99%

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Herbal formula LLKL ameliorates hyperglycaemia, modulates the gut microbiota and regulates the gut‐liver axis in Zucker diabetic fatty rats

Ding

et al. 2020

J Cellular Molecular Medi

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Type 2 diabetes mellitus (T2DM), a chronic metabolic disorder due to insulin resistance and insufficient insulin secretion, 1 is becoming a major global public health issue. 2 Over the past decades, the number of adults with diabetes has increased from 108 million in 1980 to 463 million in 2019 worldwide. 3,4 According to the data from the International Diabetes Federation, the incidence of diabetes mellitus continues to increase and will reach 700 million individuals by 2045, 4 of which T2DM accounts for more than 90%. 4 T2DM is

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Herbal formula LLKL ameliorates hyperglycaemia, modulates the gut microbiota and regulates the gut‐liver axis in Zucker diabetic fatty rats

Ding

et al. 2020

J Cellular Molecular Medi

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“…Treponema denticola and Aggregatibacter actinomycetemcomitans are increased in healthy periodontal sites in patients with insulin-dependent diabetes mellitus compared with those without diabetes mellitus (Aemaimanan et al, 2013). Decreased abundance of Treponema 2 was recorded after treatment in type 2 diabetic Goto-Kakizaki rats (Zhang et al, 2019). Campylobacter is a Gram-negative bacillus and involved in many human diseases including gastroenteritis, abortion, septicemia, inflammatory bowel disease, and periodontitis (Lee et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Association Between Serum Thyroid-Stimulating Hormone Levels and Salivary Microbiome Shifts

Zhao

Yuan

Zhu

et al. 2021

Front. Cell. Infect. Microbiol.

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High serum thyroid-stimulating hormone (TSH) levels are linked to many metabolic disorders, but the effects of TSH levels on the oral microbiota are still largely unknown. This study aimed to explore the association between the salivary microbiome in adults and serum TSH levels. Saliva and fasting blood samples were obtained from a health census conducted in Southeast China. All participants were divided according to serum TSH levels. The microbial genetic profiles and changes were acquired by 16S rDNA sequencing and bioinformatics analysis. Relevant anthropometric and biochemical measurements such as insulin resistance, blood lipids, and body composition were evaluated with laboratory tests and physical examinations. The salivary microbiome in individuals with higher TSH level showed significantly higher taxa diversity. Principal coordinates analysis and partial least squares discriminant analysis showed distinct clustering in the Abnormal and Normal Groups (Adonis, P=0.0320). Granulicatella was identified as a discriminative genus for comparison of the two groups. Fasting serum insulin, Homeostatic Model Assessment for Insulin Resistance, and hemoglobin A1 were elevated in the Abnormal Group (P<0.05), showing the presence of insulin resistance in individuals with abnormal higher serum TSH levels. Distance-based redundancy analysis revealed the association of this distinctive difference with salivary microbiome. In conclusion, shifts in microbial profile were observed in the saliva of individuals with different serum TSH levels, and insulin resistance may play an important role in the biochemical and microbial alteration.

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Anti‐diabetic and gut microbiota modulation effects of sacha inchi (Plukenetia volubilis L.) leaf extract in streptozotocin‐induced type 1 diabetic mice

et al. 2022

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BACKGROUND Sacha inchi (Plukenetia volubilis L.) tea has been used as an adjuvant treatment for diabetes in Pu’er, in the Yunnan province of China. The effects of sacha inchi tea on diabetes and the underlying mechanisms remain unknown. This study was conducted to investigate the influence of a water extract of sacha inchi (P. volubilis L.) leaves (PWE) on hypoglycemic activity and gut microbiota composition in mice with streptozotocin (STZ)‐induced type 1 diabetes mellitus (T1DM). During the 6 weeks of the study, T1DM mice were administered PWE intragastrically at 400 mg kg−1 body weight (BW) per day. RESULTS Treatment with PWE reduced excessive loss of BW and excessive intake of food. It significantly decreased blood glucose levels and improved oral glucose tolerance. The treatment caused protective histopathological transformations in sections of the pancreas, leading to decreased insulin resistance and improved insulin sensitivity. Treatment with PWE also significantly ameliorated disorders of the gut microbiota structure and increased the richness and diversity of intestinal microbial species in T1DM mice. At the genus level, the populations of several crucial bacteria, such as Akkermansia, Parabacteroides, and Muribaculum increased in the PWE treatment group but the abundance of Ruminiclostridium and Oscillibacter decreased. CONCLUSIONS Treatment with PWE can ameliorate hyperglycemic symptoms in STZ‐induced T1DM mice, and the anti‐diabetic effect of PWE was related to the amelioration of gut microbial structural disorder and the enrichment of functional bacteria. © 2022 Society of Chemical Industry.

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Extract of ice plant (Mesembryanthemum crystallinum) ameliorates hyperglycemia and modulates the gut microbiota composition in type 2 diabetic Goto-Kakizaki rats

Abstract: Ice plant extract (IPE), a rich source of d-pinitol, has a substantial effect on ameliorating hyperglycemia and modulating gut microbiota composition in diabetic GK (Goto-Kakizaki) rats.

Cited by 28 publications

References 38 publications

Herbal formula LLKL ameliorates hyperglycaemia, modulates the gut microbiota and regulates the gut‐liver axis in Zucker diabetic fatty rats

Herbal formula LLKL ameliorates hyperglycaemia, modulates the gut microbiota and regulates the gut‐liver axis in Zucker diabetic fatty rats

Association Between Serum Thyroid-Stimulating Hormone Levels and Salivary Microbiome Shifts

Anti‐diabetic and gut microbiota modulation effects of sacha inchi (Plukenetia volubilis L.) leaf extract in streptozotocin‐induced type 1 diabetic mice

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