Extract of fetal membrane would inhibit thrombosis and hemolysis

Niknejad, Hassan; Yazdanpanah, Ghasem; Kakavand, Mona

doi:10.1016/j.mehy.2015.04.030

Cited by 18 publications

(11 citation statements)

References 67 publications

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“…The use of amniotic membrane in ophthalmic surgery is on the increase. Amniotic membrane supports epithelialization and has anti-fibrotic, antiinflammatory, anti-angiogenic and anti-microbial features (Tseng 2001;Tseng et al 2004;Waked & El-Kazzi 2005;Tehrani et al 2013;Niknejad et al 2015Niknejad et al , 2016Cheng et al 2016;Deihim et al 2016). Furthermore, amniotic membrane is a rich source of biologically active factors and therefore promotes healing and acts as an effective material for wound dressing (Heerema-McKenney 2018;Kaur & Bathla 2018;Murri et al 2018;Sane et al 2018;Olaya et al 2019;Otani et al 2019).…”

Section: Introductionmentioning

confidence: 99%

A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment

Caporossi

Angelis

Pacini

et al. 2019

Acta Ophthalmologica

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Objective To assess the efficacy of the human amniotic membrane (hAM) to treat (HMMH) associated with retinal detachment (RD). Material and Methods Ten eyes of 10 patients with recurrent HMMH and RD, who had already undergone one or more pars plana vitrectomy (PPV), underwent a PPV with an hAM plug implanted in the macular hole. The initial five patients enrolled were tamponaded with (SO) while the subsequent five patients with 10% octafluoropropane (C3F8). Silicon oil was removed in all five patients 2 months later. No statistical differences were reported between the two groups. Results Final retinal reattachment was achieved in all the patients. BCVA improved from 1.73 logMAR to 0.94 logMAR after 6 months. No adverse events were registered during follow‐up. Conclusion An hAM plug is an efficient substrate to manage HMMH associated with RD resulting in encouraging visual acuity recovery.

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Section: Introductionmentioning

confidence: 99%

A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment

Caporossi

Angelis

Pacini

et al. 2019

Acta Ophthalmologica

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“…The amniotic epithelial cells contain non-intestinal-type surface microvilli, intracytoplasmic lumina lined with microvilli, and intercellular junctions; and amniotic mesenchymal cells have rough endoplasmic reticulum profiles, lipid droplets, and well-developed foci of contractile filaments with dense bodies 3 . Furthermore, the extracellular matrix of amnion (which mostly secreted by amniotic epithelial and mesenchymal cells) in the basement membrane and compact layer contains collagen, laminin 1 , elastin, fibronectin, vitronectin, nidogen 4 , and hyaluronic acid 5 , which are important for using the AM as a natural scaffold in tissue engineering and regenerative medicine 1 , 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

Induction of antimicrobial peptides secretion by IL-1β enhances human amniotic membrane for regenerative medicine

Tehrani

Modaresifar

Azizian

et al. 2017

Sci Rep

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Due to antibacterial characteristic, amnion has been frequently used in different clinical situations. Developing an in vitro method to augment endogenous antibacterial ingredient of amniotic epithelial and mesenchymal stem cells is desirable for a higher efficacy of this promising biomaterial. In this study, epithelial or mesenchymal side dependent effect of amniotic membrane (AM) on antibacterial activity against some laboratory and clinical isolated strains was investigated by modified disk diffusion method and colony count assay. The effect of exposure to IL-1β in production and release of antibacterial ingredients was investigated by ELISA assay. The results showed that there is no significant difference between epithelial and mesenchymal sides of amnion in inhibition of bacterial growth. Although the results of disk diffusion showed that the AM inhibitory effect depends on bacterial genus and strain, colony count assay showed that the extract of AM inhibits all investigated bacterial strains. The exposure of AM to IL-1β leads to a higher level of antibacterial peptides secretion including elafin, HBD-2, HBD-3 and cathelicidic LL-37. Based on these results, amniotic cells possess antibacterial activity which can be augmented by inflammatory signal inducers; a process which make amnion and its epithelial and mesenchymal stem cells more suitable for tissue engineering and regenerative medicine.

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“…Moreover, clinical outcomes of repeated autologous cultivated limbal epithelial cells' transplantation for ocular surface burns showed that the hAM is a useful promoter for stem cells' growth and differentiation [70,71]. In treating the ocular surface diseases, the hAM has shown remarkable reconstructive and regenerative capacities; moreover, it has demonstrated anti-inflammatory, antiangiogenic, and antimicrobial effects [53,54,[72][73][74][75][76][77].…”

Section: Amniotic Membrane In Ocular Anterior Segment Treatmentsmentioning

confidence: 99%

Insights on the Human Amniotic Membrane in Clinical Practice with a Focus on the New Applications in Retinal Surgery

Tartaro

Caporossi

Virgili

et al. 2020

Regen. Eng. Transl. Med.

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Lay SummaryRecently, the use of the human amniotic membrane (hAM) has been extended to treat retinal disorders such as refractory macular holes, retinal breaks and dry and wet age-related macular degeneration. Not only the hAM has proved to be an excellent tool for repairing retinal tissue, but it has also shown a promising regeneration potential. This review aims to highlight the novel use of the hAM in treating retinal diseases. Although the hAM has been used in the ocular anterior segment reconstruction for more than 60 years, in the last 2 years, we have found in literature articles showing the use of the hAM in the retinal surgery field with interesting results in terms of tissue healing and photoreceptor regeneration.

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Extract of fetal membrane would inhibit thrombosis and hemolysis

Cited by 18 publications

References 67 publications

A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment

A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment

Induction of antimicrobial peptides secretion by IL-1β enhances human amniotic membrane for regenerative medicine

Insights on the Human Amniotic Membrane in Clinical Practice with a Focus on the New Applications in Retinal Surgery

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