Extract and fraction of Cassia occidentalis L. (a synonym of Senna occidentalis) have osteogenic effect and prevent glucocorticoid-induced osteopenia

Pal, Subhashis; Kumar, Pradeep; Ramakrishna, E.; Kumar, Sudhir; Porwal, Konica; Kumar, Brijesh; Arya, K. R.; Maurya, Rakesh; Chattopadhyay, Naibedya

doi:10.1016/j.jep.2019.01.029

Cited by 35 publications

(30 citation statements)

References 38 publications

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“…Cassia occidentalis L. herbal products are widely marketed across the globe, such as Cassia Virgínica® (Laperli, Recife, Brazil) and Liv.52 DS (The Himalaya Drug Company, India) for the therapy of u and fever, and as antihepatotoxicity formulation, respectively. 2 Stems of Cassia occidentalis L. have been ethno-traditionally used in South India and South America. [3][4][5] Acute, sub-acute and reproductive toxicity of Cassia occidentalis L. was evaluated in Wistar rats and it was found to be non-toxic.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantification of five biomarkers in ethanolic extract ofCassia occidentalisLinn. stem using liquid chromatography tandem mass spectrometry: application to its pharmacokinetic studies

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Section: Introductionmentioning

confidence: 99%

Simultaneous quantification of five biomarkers in ethanolic extract ofCassia occidentalisLinn. stem using liquid chromatography tandem mass spectrometry: application to its pharmacokinetic studies

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“…28 Following scanning and reconstruction, data analysis was performed as described before. 28 Following scanning and reconstruction, data analysis was performed as described before.…”

Section: Microcomputed Tomography (μCt)mentioning

confidence: 99%

“…The excised bone from mice was subjected to SkyScan 1076 CT scanner (SkyScan, Asrtselaar, Belgium) as described previously. 28 Following scanning and reconstruction, data analysis was performed as described before. 24…”

Section: Microcomputed Tomography (μCt)mentioning

confidence: 99%

Fasciola helminth defense molecule‐1 protects against experimental arthritis by inhibiting osteoclast formation and function without modulating the systemic immune response

et al. 2019

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An inverse correlation between helminth infection and the autoimmune disease appears to be contributed by the anti-inflammatory factors produced by these organisms. Suppressing osteoclast function without affecting the systemic immunological response is an emerging therapeutic strategy for rheumatoid arthritis (RA). We observed that a synthetic peptide corresponding to 34 amino acids of C-terminal sequence of Fasciola helminth defense molecule-1 (C-FhHDM-1) inhibited RANKLinduced osteoclast formation and lysosomal acidification with an attendant upregulation of sequestome1/p62, a negative regulator of NF-κB expression. C-FhHDM-1 also suppressed RANKL production from osteoblasts. Macrophages are the major inflammatory cells in the joints of RA and C-FhHDM-1 suppressed ICAM-1 (an inflammatory surrogate) expression in these cells. In a murine model of collagen II-induced arthritis (CIA), C-FhHDM-1 improved clinical score, protected against cartilage destruction, and maintained bone mass and bone architecture of joints compared with the CIA group. C-FhHDM-1 suppressed the CIA-induced expression of TNF, IL-17, and IFN-γ in joints but not their serum levels. The peptide also had no effect on the CIA-induced suppression of T regulatory response. We conclude that C-FhHDM-1 has a joint-specific protective effect in experimental arthritis without mitigating systemic inflammation, and thus could become an adjuvant anti-arthritis therapy to prevent RA-induced osteopenia.

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“…Traditional uses of leaf and stem of C. occidentalis for the treatment of fracture and ailments of bone are known since the late nineteenth century in Puttur, a census town of Chittoor district of Andhra Pradesh, a Southern state of India 12,13 . We have recently shown that a butanolic fraction made from the ethanolic extract of C. occidentalis's stem promotes bone regeneration at the fracture site and protected against methylprednisone (MP)-induced loss of bone mass and strength in rats 14 . In this regard, the butanolic fraction (CSE-Bu) was found to be more potent than the ethanolic extract.…”

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“…Self-nano emulsifying drug delivery system (SEDDS) is an efficient approach for enhancing intestinal absorption of hydrophobic compounds that are present in CSE-Bu, leading to their improved bioavailability and more consistent temporal profile of their absorption. CSE-Bu contains six osteogenic compounds out of which isovitexin had the best osteogenic effect in vitro 14 .…”

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A butanolic fraction from the standardized stem extract of Cassia occidentalis L delivered by a self-emulsifying drug delivery system protects rats from glucocorticoid-induced osteopenia and muscle atrophy

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et al. 2020

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We recently reported that a butanol soluble fraction from the stem of Cassia occidentalis (cSe-Bu) consisting of osteogenic compounds mitigated methylprednisone (Mp)-induced osteopenia in rats, albeit failed to afford complete protection thus leaving a substantial scope for further improvement. to this aim, we prepared an oral formulation that was a lipid-based self-nano emulsifying drug delivery system (CSE-BuF). The globule size of CSE-BuF was in the range of 100-180 nm of diluted emulsion and the zeta potential was −28 mV. CSE-BuF enhanced the circulating levels of five osteogenic compounds compared to CSE-Bu. CSE-BuF (50 mg/kg) promoted bone regeneration at the osteotomy site and completely prevented Mp-induced loss of bone mass and strength by concomitant osteogenic and anti-resorptive mechanisms. The MP-induced downregulations of miR29a (the positive regulator of the osteoblast transcription factor, Runx2) and miR17 and miR20a (the negative regulators of the osteoclastogenic cytokine RAnKL) in bone was prevented by cSe-Buf. in addition, cSe-Buf protected rats from the MP-induced sarcopenia and/or muscle atrophy by downregulating the skeletal muscle atrogenes, adverse changes in body weight and composition. cSe-Buf did not impact the antiinflammatory effect of MP. Our preclinical study established CSE-BuF as a prophylactic agent against Mp-induced osteopenia and muscle atrophy. Worldwide nearly 60% of patients of rheumatoid arthritis (RA) are treated with glucocorticoids (GC) 1. Prednisone/methylprednisolone, the most frequently used GC is given in combination with disease modifying anti-rheumatic drugs (DMARDs) to provide better clinical benefit. However, long-term use of GC has several metabolic adverse effects and the most prominent among those being osteoporosis and sarcopenia 2,3. The clinically used drugs for GC-induced osteoporosis (GIO) are anti-resorptives (bisphosphonates and denosumab)

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Extract and fraction of Cassia occidentalis L. (a synonym of Senna occidentalis) have osteogenic effect and prevent glucocorticoid-induced osteopenia

Cited by 35 publications

References 38 publications

Simultaneous quantification of five biomarkers in ethanolic extract ofCassia occidentalisLinn. stem using liquid chromatography tandem mass spectrometry: application to its pharmacokinetic studies

Simultaneous quantification of five biomarkers in ethanolic extract ofCassia occidentalisLinn. stem using liquid chromatography tandem mass spectrometry: application to its pharmacokinetic studies

Fasciola helminth defense molecule‐1 protects against experimental arthritis by inhibiting osteoclast formation and function without modulating the systemic immune response

A butanolic fraction from the standardized stem extract of Cassia occidentalis L delivered by a self-emulsifying drug delivery system protects rats from glucocorticoid-induced osteopenia and muscle atrophy

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