Extracorporeal treatments in a dapsone overdose: a case report

Abstract

Dapsone clearance was enhanced by ECTR, especially by IHD-HP. However, HP was associated with severe asymptomatic thrombocytopenia.

Treatment of a life-threatening dapsone intoxication

“…In view of the high volume of distribution, high degree of protein binding and minimal excretion of unchanged drug the usefulness of extracorporeal treatments to accelerate the clearance of dapsone is questionable. In the literature however there is some evidence that hemodialysis could accelerate the clearance of dapsone [9] , [10] . Due to the excessive dose of dapsone taken, hemodialysis was performed in this case.…”