Treatment of a life-threatening dapsone intoxication

Veerman, M.H.; van Gelder, T.; Sneijder, R.; Bethlehem, C.

doi:10.1016/j.toxrep.2023.10.006

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“…Interestingly, our chart review did not reveal any fatalities related to dapsone, although this may be related to all cases being associated with therapeutic dosing and not overdoses. Life-threatening methemoglobinemia has been known to occur with intentional overdoses of dapsone [51] . Routine protocols for monitoring methemoglobin levels as part of ongoing therapy with dapsone at our institution may have contributed to the high percentage of methemoglobinemia accounted for by dapsone, as many patients showing methemoglobinemia related to dapsone were asymptomatic at the time of testing.…”

Section: Discussionmentioning

confidence: 99%