Extracorporeal Membrane Oxygenation: Quo Vadis?

Betit, Peter

doi:10.4187/002013209793800402

Cited by 26 publications

(22 citation statements)

References 68 publications

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“…[26][27][28] In the experiments here, almost all generated microbubbles after the application of sonication had diameters of 1.5 µm, which were considered as fine microbubbles, including nanobubbles, suggesting that sonication is a useful method to generate finer microbubbles with nanobubbles ( Figure 2B). Sonication may divide generated microbubbles into finer MNBs.…”

Section: Discussionmentioning

confidence: 99%

Oxygen supersaturated fluid using fine micro/nanobubbles

Matsuki¹,

Ishikawa²,

Ichiba³

et al. 2014

IJN

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Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.

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Section: Discussionmentioning

confidence: 99%

Oxygen supersaturated fluid using fine micro/nanobubbles

Matsuki¹,

Ishikawa²,

Ichiba³

et al. 2014

IJN

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“…(1,2,7) Respiratory failure in children was the latest indication introduced for ECMO and use of ECMO for this group of patients has increased steadily, leveling off in the nineties, but recently it has been reported to be slightly increasing again. (2,8) The survival of pediatric respiratory ECMO is 50-55%. (8) There are no fixed inclusion criteria for pediatric respiratory ECMO, and ECMO is usually started if there is a high probability of a lethal outcome despite maximal conventional therapy.…”

Section: Discussionmentioning

confidence: 99%

“…(2,8) The survival of pediatric respiratory ECMO is 50-55%. (8) There are no fixed inclusion criteria for pediatric respiratory ECMO, and ECMO is usually started if there is a high probability of a lethal outcome despite maximal conventional therapy. Lung disease should be considered to be reversible; the patient should be mechanically ventilated for less than 14 days; and no other organs major complications (significant neurologic morbidity, ongoing hemorrhagic condition, or multiple organ system failure) should be present when starting ECMO.…”

Section: Discussionmentioning

confidence: 99%

“…Lung disease should be considered to be reversible; the patient should be mechanically ventilated for less than 14 days; and no other organs major complications (significant neurologic morbidity, ongoing hemorrhagic condition, or multiple organ system failure) should be present when starting ECMO. (1,7,8). Unlike neonates, OI is not as predictive for ECMO use in children and is not tightly used for guiding the indications for pediatric respiratory ECMO.…”

Section: Discussionmentioning

confidence: 99%

“…When we decided to start ECMO, we considered that there was a high probability of death with conventional support. Therefore, the majority of proposed inclusion criteria for pediatric respiratory ECMO, which are sometimes used, (7,8) were met in our patient. Community-acquired infections with PVL toxin producing S. aureus are rare, but often invasive and associated with toxic shock-like illness, necrotizing pneumonia with complications (pneumatocoeles, recurrent pneumothoraces, pleural effusion, empyema and lung abscesses), and osteoarticular infections with venous thrombosis (3,9-13) as in our patient.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Successful use of venovenous extracorporeal membranous oxygenation in a 22-month old boy with necrotizing pneumonia, osteomyelitis and septic shock caused by Panton Valentine leukocidin – producing Staphylococcus aureus

Groselj-Grenc

Kalan

Vidmar

et al. 2011

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Identifying an optimal seeding protocol and endothelial cell substrate for biohybrid lung development

Zwirner

Höffler

Pflaum

et al. 2018

J Tissue Eng Regen Med

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Several key prerequisites need to be fulfilled for the development of a biohybrid lung, which can offer an actual alternative to lung transplantation. A major aspect is an optimized haemocompatibility of the device's artificial surfaces via endothelial cell seeding. In this study, four different types of polymeric gas exchange hollow fibre membranes (HFMs) were analysed utilizing four different seeding protocols in order to identify the ideal combination for sufficient long-term endothelialization.Human cord blood-derived endothelial cells (HCBECs) were used for the endothelialization of polypropylene HFMs with two different pore sizes and poly-4-methyl-1pentene HFMs, both with and without heparin/albumin coating. The qualitative and quantitative impact of four different rotational seeding protocols regarding longterm HFM endothelialization and the impact of inflammatory stimulation on the seeded HCBECs were examined by fluorescence microscopy, cell counting, and analysis of relative expression levels of activation, shear stress, and thrombogenic state markers. Optimized endothelial cell seeding and long-term cultivation were only achieved using heparin/albumin-coated poly-4-methyl-1-pentene HFMs, applying 24 hr of rotational speed at 1 rpm followed by 120 hr of static culture. Neither cell-to-HFM contact nor the rotational cultivation procedure showed an impact on the physiological anti-thrombogenic and anti-inflammatory HCBEC activation status.Additionally, the cells maintained their physiological responsiveness towards inflammatory stimulation. Rotational seeding strategies and a seamless heparin/albumin coating of the HFMs are crucial requirements for a sufficient and long-lasting endothelialization and thus a key element in the future development and in vivo application of the biohybrid lung.

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Extracorporeal Membrane Oxygenation: Quo Vadis?

Cited by 26 publications

References 68 publications

Oxygen supersaturated fluid using fine micro/nanobubbles

Oxygen supersaturated fluid using fine micro/nanobubbles

Successful use of venovenous extracorporeal membranous oxygenation in a 22-month old boy with necrotizing pneumonia, osteomyelitis and septic shock caused by Panton Valentine leukocidin – producing Staphylococcus aureus

Identifying an optimal seeding protocol and endothelial cell substrate for biohybrid lung development

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