Oxygen supersaturated fluid using fine micro/nanobubbles

Matsuki, Noriaki; Ishikawa, Takuji; Ichiba, Shingo; Shiba, Naoki; Ujike, Yoshihito; Yamaguchi, Takami

doi:10.2147/ijn.s68840

Cited by 61 publications

(68 citation statements)

References 33 publications

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“…255,256,257,258 Moreover, the opportunity exists currently to further test the effects of supplemental O 2 ; more modern standards of clinical trials such as establishing dose/response, effects of treatment duration, minimum dosing necessary etc. should surely be attempted as a simple yet potentially effective intervention.…”

Section: Potential Drug Targets Of Important Placental Pathways Imentioning

confidence: 99%

Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Ilekis

Tsilou

Fisher

et al. 2016

American Journal of Obstetrics and Gynecology

233

167

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Although much progress is being made in understanding the molecular pathways in the placenta involved in the pathophysiology of pregnancy related disorders, a significant gap exists in utilizing this information for developing new drug therapies to improve pregnancy outcome. On March 5–6, 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health sponsored a two day workshop titled Placental Origins of Adverse Pregnancy Outcomes: Potential Molecular Targets to begin to address this gap. Particular emphasis was given in the identification of important molecular pathways that could serve as drug targets and the advantages and disadvantages of targeting these particular pathways. This article is a summary of the proceedings of this workshop. A broad number of topics were covered ranging from basic placental biology to clinical trials. This included research in the basic biology of placentation, such as trophoblast migration and spiral artery remodeling, and trophoblast sensing and response to infectious and non-infectious agents. Research findings in these areas will be critical for formulating developing future treatments and developing therapies for the prevention of a number of pregnancy disorders of placental origin including preeclampsia, fetal growth restriction, and uterine inflammation. Research was also presented summarizing ongoing clinical efforts in the U.S. and in Europe testing novel interventions for preeclampsia and fetal growth restriction, including agents such as oral arginine supplementation, sildenafil, pravastatin, gene therapy using virally-delivered vascular endothelial growth factor, and oxygen supplementation therapy. Strategies were also proposed to improve fetal growth by enhancing nutrient transport to the fetus by modulating their placental transporters, as well as targeting placental mitochondrial dysfunction and oxidative stress to improve placental health. The roles of microRNAs and placental-derived exosomes, as well as messenger RNAs, were also discussed in the context of their use for diagnostics and as drug targets. The workshop discussed the aspect of safety and pharmacokinetic profiles of potential existing and new therapeutics that will need to be determined especially in the context of the unique pharmacokinetic properties of pregnancy, as well as the hurdles and pitfalls of translating research findings into practice. The workshop also discussed novel methods of drug delivery and targeting during pregnancy using macromolecular carriers, such as nanoparticles and biopolymers, to minimize placental drug transfer and hence fetal drug exposure. In closing, a major theme that developed from the workshop was that the scientific community needs to change their thinking of the pregnant women and her fetus as a vulnerable patient population for which drug development should be avoided, but rather thought of as a deprived population in need of more effective therapeutic interventions.

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Section: Potential Drug Targets Of Important Placental Pathways Imentioning

confidence: 99%

Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Ilekis

Tsilou

Fisher

et al. 2016

American Journal of Obstetrics and Gynecology

233

167

View full text Add to dashboard Cite

show abstract

“…When MNBs are produced in water using oxygen or air as gas impregnated in their core, their negatively charged surface not only prevents them from merging together, which would cause them to lose their properties, but also attracts particulate matter and assists in the removal of debris . In addition, MNBs generate free radicals as they shrink, which potentially contributes to their antibacterial effects . Nanobubbles and microbubbles that shrink to become nanobubbles exist in a solution for different time periods depending on the conditions in which they are formed …”

Section: G Micro/nanobubblesmentioning

confidence: 99%

“…Matsuki et al was the first to apply MNBs to common infusions in daily medical care . They demonstrated that saline is the preferred solution for MNBs and that MNBs formed in dextran showed the highest pO 2 at 60 minutes .…”

Section: G Micro/nanobubblesmentioning

confidence: 99%

Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery

Sayadi

Banyard

Ziegler

et al. 2018

International Wound Journal

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Up to 15 billion dollars of US health care expenditure each year is consumed by treatment of poorly healing wounds whose etiologies are often associated with aberrancies in tissue oxygenation. To address this issue, several modes of tissue oxygen delivery systems exist, including Hyperbaric Oxygen Therapy (HBOT) and Topical Oxygen Therapy (TOT), but their efficacies have yet to be fully substantiated. Micro/nanobubbles (MNBs), which range anywhere from 100 μm to <1 μm in diameter and are relatively stable for hours, offer a new mode of oxygen delivery to wounds. The aim of this article is to systematically review literature examining the use of TOT for wound healing and use of MNBs for tissue oxygenation using the MEDLINE database. The search yielded 87 articles (12 MNB articles and 75 TOT articles), of which 52 met the inclusion criteria for this literature review (12 MNB articles and 40 TOT articles). Additionally, we present an analysis on the efficacy of our MNB generating technology and propose its use as a wound healing agent.

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“…Bubble gas is important in the application of fine bubbles. For example, fluorocarbon microbubbles are preferably used as an ultrasound contrast reagent [22], whereas oxygen bubbles (OBs) are inevitably used for blood oxygenation [5,23].…”

Section: Introductionmentioning

confidence: 99%

Control of hydrogen bubble plume during electrolysis of water

et al. 2019

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Hydrogen bubble plumes are generated from the cathode during electrolysis. The plume formation mechanism contributes to the control of bubble diameters and alignment in solvent. The generation of hydrogen bubbles (HBs) and oxygen bubbles (OBs) from electrodes was observed in tap water and saline using a high-speed microscope. Bubble diameter changes were analysed from the obtained microscopic images, and the growth kinetics of HBs and OBs were compared. The result showed that plume formation was primarily dependent on ion strength of water and not voltage to the electrode. HB diameter change in plume was proportional to the distance from the cathode in tap water. Such correlation between HB diameter and distance from the cathode was not observed in saline. By simultaneous observation of HBs and OBs attached to the electrodes, the increase in HB diameter was faster than that of OB. The kinetic properties in HBs and OBs were proportional to (time) 1/2 and (time) 1 , respectively, suggesting that the diffusion of oversaturated hydrogen gas and pressure difference at OB surfaces were dominant. Based on these results, HB plume formation was determined by the lower gas solubility and mass density of HB than that of OB, as well as controlled by voltage and ionic strength of water.

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Oxygen supersaturated fluid using fine micro/nanobubbles

Cited by 61 publications

References 33 publications

Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery

Control of hydrogen bubble plume during electrolysis of water

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