Extracolonic Cancers Associated with Hereditary Nonpolyposis Colorectal Cancer in the Utah Population Database

Abstract

In this population-based examination of the extracolonic cancers at excess in classic HNPCC pedigrees (selected by Amsterdam I criteria) we not only observed many of the same cancers previously reported to be associated with HNPCC in both CRC probands and their relatives, but also identified several previously unreported associations. Although our sample size is small, this study is population based, lacks ascertainment and recall bias, and benefits from uniform, consistent diagnoses of all cancers in a statewide registry.

Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

“…Amazingly, the frequency of uterus cancer among female members of the HNPCC families has been less than our prediction according to the previous studies (Park et al, 2000;Maul et al, 2006;Pickhardt et al, 2010;Vasen et al, 2013). It may be due to some specific genetic characteristics of our populations about which more future researches would be helpful.…”

“…Meanwhile, there are significant discrepancies, 33-78%, between similar studies in other countries (Park et al, 2000;Maul et al, 2006;da Silva et al, 2010;Bansidhar, 2012).…”

“…In a Brazilian study, GC was the second most common extracolonic cancer in HNPCC families (da Silva et al, 2010). In addition, several Chinese and Korean studies have presented GC as the most common extracolonic cancer in HNPCC (Park et al, 2000), while in Western populations, the prevalence of GC within HNPCC cohorts is the third or fourth most common cancer (Maul et al, 2006;Bansidhar, 2012). These discrepancies could be related to environmental factors (Vasen et al, 2013).…”

Risk of Prostate Cancer in Lynch Syndrome: A Systematic Review and Meta-analysis

“…25,26,[28][29][30][31]. Of the 12 studies that did quantify the risk, six of these reported a statistically significant increase in prostate cancer for Lynch syndrome (19,27,32,33,35,36). The remaining six studies found no evidence for an increased risk of prostate cancer (14,15,(22)(23)(24)34).…”

“…Attempts have been made to directly estimate the risk of prostate cancer in Lynch syndrome using studies of cancer history of men from Lynch syndrome families (14,15,19,(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36). These studies have generally been limited in terms of size and analytic methods used, so as a consequence, estimates are imprecise and inconsistent.…”