Extracellular vesicles: Emerging tools as therapeutic agent carriers

Liu, Shan; Wu, Xue; Chandra, Sutapa; Lyon, Christopher J.; Ning, Bo; Li, Jiang; Fan, Jia; Hu, Tony

doi:10.1016/j.apsb.2022.05.002

Cited by 51 publications

(49 citation statements)

References 174 publications

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“…There has been great progress in creating novel methods for different therapeutic approaches, such as 3D bioprinting, hydrogels, and nanoparticles in different diseases [ 56 , 57 , 58 , 59 , 60 ]. Yet, within the past decade, EVs have emerged as a therapeutic tool and potential vehicle for targeted therapy due to their exceptional biocompatibility and physiochemical stability [ 36 , 61 , 62 ]. EVs are nanosized particles with a lipid bilayer that contains a repertoire of intrinsic cargo: mRNA, miRNA, lipids, and proteins derived from the origin cell type [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Doxorubicin-Loaded Extracellular Vesicles Enhance Tumor Cell Death in Retinoblastoma

et al. 2022

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Chemotherapy is often used to treat retinoblastoma; however, this treatment method has severe systemic adverse effects and inadequate therapeutic effectiveness. Extracellular vesicles (EVs) are important biological information carriers that mediate local and systemic cell-to-cell communication under healthy and pathological settings. These endogenous vesicles have been identified as important drug delivery vehicles for a variety of therapeutic payloads, including doxorubicin (Dox), with significant benefits over traditional techniques. In this work, EVs were employed as natural drug delivery nanoparticles to load Dox for targeted delivery to retinoblastoma human cell lines (Y-79). Two sub-types of EVs were produced from distinct breast cancer cell lines (4T1 and SKBR3) that express a marker that selectively interacts with retinoblastoma cells and were loaded with Dox, utilizing the cells’ endogenous loading machinery. In vitro, we observed that delivering Dox with both EVs increased cytotoxicity while dramatically lowering the dosage of the drug. Dox-loaded EVs, on the other hand, inhibited cancer cell growth by activating caspase-3/7. Direct interaction of EV membrane moieties with retinoblastoma cell surface receptors resulted in an effective drug delivery to cancer cells. Our findings emphasize the intriguing potential of EVs as optimum methods for delivering Dox to retinoblastoma.

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Section: Discussionmentioning

confidence: 99%

Doxorubicin-Loaded Extracellular Vesicles Enhance Tumor Cell Death in Retinoblastoma

et al. 2022

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“…The rapid advancements in materials science and nanotechnology have attracted increasing interest, and various materials including inorganic/organic nanoparticles (NPs), [15][16][17][18] hydrogels 19,20 and extracellular vesicles 21 have been used for cancer vaccination in recent years. These materials have been demonstrated to effectively augment the immune response of vaccines by improving innate immune cell activation, increasing antigen production and stability, improving antigen loading efficiency, targeting lymph node delivery or promoting antigen cross-presentation.…”

Section: Linqi Shimentioning

confidence: 99%

Polymeric nanoparticle-based nanovaccines for cancer immunotherapy

et al. 2023

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“…The targeted delivery of EV cargoes to recipient cells plays essential roles in intercellular signal transduction and tissue homeostasis. EV-mediated cell-to-cell communication is regulated by three primary mechanisms: receptor-ligand interactions, direct plasma membrane fusion, and internalization into recipient cells [ 72 ]. The regenerative potential of EVs is mainly attributed to their direct impact on target cells in the regulation of cell apoptosis, proliferation, and differentiation, as well as their indirect effects on enhancing angiogenesis and modulating the immune microenvironment.…”

Section: Mechanisms Of Evs In Tissue Regenerationmentioning

confidence: 99%

Extracellular Vesicles for Dental Pulp and Periodontal Regeneration

Lai

Kou

et al. 2023

Pharmaceutics

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Extracellular vesicles (EVs) are lipid bound particles derived from their original cells, which play critical roles in intercellular communication through their cargoes, including protein, lipids, and nucleic acids. According to their biogenesis and release pathway, EVs can be divided into three categories: apoptotic vesicles (ApoVs), microvesicles (MVs), and small EVs (sEVs). Recently, the role of EVs in oral disease has received close attention. In this review, the main characteristics of EVs are described, including their classification, biogenesis, biomarkers, and components. Moreover, the therapeutic mechanism of EVs in tissue regeneration is discussed. We further summarize the current status of EVs in pulp/periodontal tissue regeneration and discuss the potential mechanisms. The therapeutic potential of EVs in pulp and periodontal regeneration might involve the promotion of tissue regeneration and immunomodulatory capabilities. Furthermore, we highlight the current challenges in the translational use of EVs. This review would provide valuable insights into the potential therapeutic strategies of EVs in dental pulp and periodontal regeneration.

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Extracellular vesicles: Emerging tools as therapeutic agent carriers

Cited by 51 publications

References 174 publications

Doxorubicin-Loaded Extracellular Vesicles Enhance Tumor Cell Death in Retinoblastoma

Doxorubicin-Loaded Extracellular Vesicles Enhance Tumor Cell Death in Retinoblastoma

Polymeric nanoparticle-based nanovaccines for cancer immunotherapy

Extracellular Vesicles for Dental Pulp and Periodontal Regeneration

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