Extracellular vesicles derived from astrocytes facilitated neurite elongation by activating the Hippo pathway

Sun, Haitao; Cao, Xingbing; Gong, Aihua; Huang, Yonghui; Xu, Yi; Zhang, Jinglong; Sun, Jie; Lv, Bin; Li, Zhen; Guan, Shihao; Lü, Ling; Yin, Guoyong

doi:10.1016/j.yexcr.2021.112937

Cited by 7 publications

(4 citation statements)

References 71 publications

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“…Neurotoxic proteins may be present, resulting in neurodegeneration [65]. Reactive astrocytes can shed increased quantity of EVs to aid tissue healing [66].…”

Section: Central Nervous System As a Target And Niche For Evsmentioning

confidence: 99%

Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System Diseases

Zanirati,

dos Santos,

Alcará

et al. 2024

Preprint

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It has been widely established that the characterization of extracellular vesicles (EVs), particularly small EVs (sEVs), shed by different cell types into biofluids, helps identify biomarkers and therapeutic targets in neurological and neurodegenerative diseases. Recent studies are also exploring the efficacy of mesenchymal stem cell-derived extracellular vesicles naturally enriched with therapeutic microRNAs and proteins for treating various diseases. Besides, EVs released by various neural cells play a crucial function in the modulation of signal transmission in the brain in physiological conditions. However, in pathological conditions, such EVs can facilitate the spread of pathological proteins from one brain region to the other. On the other hand, analysis of EVs in biofluids can identify sensitive biomarkers for diagnosis, prognosis, and disease progression. This review discusses the potential therapeutic use of stem cell-derived EVs in several central nervous system diseases. It lists their differences and similarities and confers various studies exploring EVs as biomarkers. Further advances in EV research in the coming years will likely lead to the routine use of EVs in therapeutic settings.

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“…Neurotoxic proteins may be present, resulting in neurodegeneration [65]. Reactive astrocytes can shed increased quantity of EVs to aid tissue healing [66].…”

Section: Central Nervous System As a Target And Niche For Evsmentioning

confidence: 99%

Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System Diseases

Zanirati,

dos Santos,

Alcará

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Meanwhile, cluster 2 is characterized by the core keywords "vesicle" [60][61][62], "source" [63,64], "miRNAs" [65,66] and "biomarker" [67][68][69]. Lastly, cluster 3 is distinguished by "bone marrow mesenchymal stem cells" [70][71][72], "lipopolysaccharide" [73,74], "angiogenesis" [75][76][77], "apoptosis" [78,79], "polarization" [80,81], "migration" [82,83], "hydrogel" [84,85], "cell communication" [86,87], and "mechanism" [88,89] as its core keywords.…”

Section: Keyword Analysis Of Global Research Keyword Co-existence Net...mentioning

confidence: 99%

A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis

Zhiguo,

Ji,

Shenyuan

et al. 2023

J Nanobiotechnol

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Extracellular vesicles (EVs) in the field of spinal cord injury (SCI) have garnered significant attention for their potential applications in diagnosis and therapy. However, no bibliometric assessment has been conducted to evaluate the scientific progress in this area. A search of articles in Web of Science (WoS) from January 1, 1991, to May 1, 2023, yielded 359 papers that were analyzed using various online analysis tools. These articles have been cited 10,842 times with 30.2 times per paper. The number of publications experienced explosive growth starting in 2015. China and the United States led this research initiative. Keywords were divided into 3 clusters, including “Pathophysiology of SCI”, “Bioactive components of EVs”, and “Therapeutic effects of EVs in SCI”. By integrating the average appearing year (AAY) of keywords in VoSviewer with the time zone map of the Citation Explosion in CiteSpace, the focal point of research has undergone a transformative shift. The emphasis has moved away from pathophysiological factors such as “axon”, “vesicle”, and “glial cell” to more mechanistic and applied domains such as “activation”, “pathways”, “hydrogels” and “therapy”. In conclusions, institutions are expected to allocate more resources towards EVs-loaded hydrogel therapy and the utilization of innovative materials for injury mitigation.

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“…Glial cells play an important role in promoting axonal growth. EVs from astrocytes and LPS-pre-activated astrocytes can activate the Hippo pathway, promote the expression of monopole spindle-binding protein 1 (MOB1), and reduce the level of Yes-associated protein (YAP), thereby facilitating neurite outgrowth and recovery after SCI [93]. The miR-151-3p is highly expressed in microglial exosomes and promotes axon regeneration in vitro and in vivo, which may involve downstream activation of the p53/p21/CDK1 signaling cascade [94].…”

Section: Promoting Axon Regenerationmentioning

confidence: 99%

Extracellular vesicle therapy for traumatic central nervous system disorders

Zhang

Shi

et al. 2022

Stem Cell Res Ther

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Traumatic central nervous system (CNS) disorders have catastrophic effects on patients, and, currently, there is no effective clinical treatment. Cell transplantation is a common treatment for traumatic CNS injury in animals. In recent years, an increasing number of studies have reported that the beneficial effect of transplanted cells for CNS repair is mediated primarily through the extracellular vesicles (EVs) secreted by the cells, in which microRNAs play a major role. Accordingly, numerous studies have evaluated the roles and applications of EVs secreted by different cell types in neurological diseases. Furthermore, due to their unique biological features, EVs are used as disease biomarkers and drug delivery systems for disease prevention and treatment. We discuss current knowledge related to EVs, focusing on the mechanism underlying their effects on traumatic CNS diseases, and summarize existing research on the potential clinical utility of EVs as disease biomarkers and drug delivery systems.

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Extracellular vesicles derived from astrocytes facilitated neurite elongation by activating the Hippo pathway

Cited by 7 publications

References 71 publications

Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System Diseases

Extracellular Vesicles: The Next Generation of Biomarkers and Treatment for Central Nervous System Diseases

A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis

Extracellular vesicle therapy for traumatic central nervous system disorders

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