Extracellular vesicles carrying proinflammatory factors may spread atherosclerosis to remote locations

Peng, Mengna; Sun, Rui; Hong, Ye; Wang, Jia; Xie, Yi; Zhang, Xiaohao; Li, Juanji; Guo, Hua; Xu, Pengfei; Li, Yunzi; Wang, Xiaoke; Wan, Ting; Zhao, Ying; Huang, Feihong; Wang, Yuhui; Ye, Richard D.; Liu, Qian; Liu, George; Liu, Xinfeng; Xu, Gelin

doi:10.1007/s00018-022-04464-2

Cited by 15 publications

(12 citation statements)

References 59 publications

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“…On the contrary, cardiac stem-cell-derived exosomes can reduce scar tissue formation ( 34 ). Exosome microRNAs play a major role in limiting the development of atherosclerosis ( 35 ). However, the role of exosome-derived circRNAs in coronary artery disease is still poorly studied.…”

Section: Discussionmentioning

confidence: 99%

circRNA, a novel diagnostic biomarker for coronary heart disease

Tong

Zhao²,

Dang³

et al. 2023

Front. Cardiovasc. Med.

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ObjectiveThis study aimed to identify the potential diagnostic biomarkers of coronary heart disease (CHD) from exosome-derived circRNA.MethodsThe microarray data of circRNA derived from the exosomes of patients with CHD and mRNA in acute myocardial infarction was retrieved from exoRBase website and GEO database (GSE61144), respectively, to identify the differentially expressed genes (DEGs). Our findings detected the differentially expressed circRNAs and mRNAs and predicted their correlation with microRNAs using the microRNA target prediction website, thus ascertaining the corresponding circ-microRNA and micro-mRNAs. Then, we performed systematic Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis on the differentially expressed mRNA. Protein-Protein Interactions (PPI) of these DEGs were examined using STRING. The receiver operator characteristic (ROC) curve was used to validate the diagnostic efficacy of circRNA in patients with CHD. Finally, the RNAs identified in this study were verified by quantitative real-time polymerase chain reaction (qRT-PCR).ResultsA total of 85 differentially expressed circRNAs (4 up-regulated and 81 down-regulated) were identified by screening the circRNAs in exosome of CHD patients. Based on the prediction data of circRNA, mRNA, and the corresponding microRNA, a ceRNA network was constructed, including 7 circRNA nodes, 5 microRNA nodes, and 2 mRNA nodes. Finally, validated by qRT-PCR testing, we found circRNA0001785, circRNA0000973, circRNA0001741, and circRNA0003922 to be the promising candidate for the effective prediction of CHD. These potential diagnostic markers can provide insight for further research on the occurrence of CHD or even acute coronary syndrome (ACS).

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Section: Discussionmentioning

confidence: 99%

circRNA, a novel diagnostic biomarker for coronary heart disease

Tong

Zhao²,

Dang³

et al. 2023

Front. Cardiovasc. Med.

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“…Epigenetic changes contribute to the development of CVDs and begin with progressive alterations of the endothelial tissue [ 3 , 7 ]. Endothelial dysfunction is characterized by impaired vascular function, loss of antithrombotic function, excessive proliferation of vascular smooth muscle cells (VSMCs), platelet activation and macrophage migration [ 9 , 39 ]. In endothelial dysfunctional cells, intercellular and vascular cell adhesion molecule-1 (ICAM-1 and VCAM-1) are overexpressed and promote the leukocytes’ adhesion [ 40 ].…”

Section: The Epigenetic Role Of Evs In Cardiovascular Damagementioning

confidence: 99%

Basic Pathogenic Mechanisms and Epigenetic Players Promoted by Extracellular Vesicles in Vascular Damage

Schiano

Balbi²,

Nigris

et al. 2023

IJMS

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Both progression from the early pathogenic events to clinically manifest cardiovascular diseases (CVD) and cancer impact the integrity of the vascular system. Pathological vascular modifications are affected by interplay between endothelial cells and their microenvironment. Soluble factors, extracellular matrix molecules and extracellular vesicles (EVs) are emerging determinants of this network that trigger specific signals in target cells. EVs have gained attention as package of molecules with epigenetic reversible activity causing functional vascular changes, but their mechanisms are not well understood. Valuable insights have been provided by recent clinical studies, including the investigation of EVs as potential biomarkers of these diseases. In this paper, we review the role and the mechanism of exosomal epigenetic molecules during the vascular remodeling in coronary heart disease as well as in cancer-associated neoangiogenesis.

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“…Other studies have shown that dendritic cells take up circulating EVs from other dendritic cells, and their cargo proteins are processed and presented as antigens, playing a role in immune regulation [ 33 , 34 ]. Among other pathological conditions they are involved in, cancer has received the most attention [ 35 , 36 ], but EVs also play a role in neurodegenerative diseases such as Alzheimer’s [ 37 ] and cardiovascular diseases such as atherosclerosis [ 38 ], as well as infectious diseases such as HIV-1 infection [ 39 ].…”

Section: The Interest Of Evs In Solid Organ Transplantationmentioning

confidence: 99%

Extracellular Vesicles: The Future of Diagnosis in Solid Organ Transplantation?

Romero-García

Huete-Acevedo

Mas-Bargues

et al. 2023

IJMS

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Solid organ transplantation (SOT) is a life-saving treatment for end-stage organ failure, but it comes with several challenges, the most important of which is the existing gap between the need for transplants and organ availability. One of the main concerns in this regard is the lack of accurate non-invasive biomarkers to monitor the status of a transplanted organ. Extracellular vesicles (EVs) have recently emerged as a promising source of biomarkers for various diseases. In the context of SOT, EVs have been shown to be involved in the communication between donor and recipient cells and may carry valuable information about the function of an allograft. This has led to an increasing interest in exploring the use of EVs for the preoperative assessment of organs, early postoperative monitoring of graft function, or the diagnosis of rejection, infection, ischemia-reperfusion injury, or drug toxicity. In this review, we summarize recent evidence on the use of EVs as biomarkers for these conditions and discuss their applicability in the clinical setting.

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Extracellular vesicles carrying proinflammatory factors may spread atherosclerosis to remote locations

Cited by 15 publications

References 59 publications

circRNA, a novel diagnostic biomarker for coronary heart disease

circRNA, a novel diagnostic biomarker for coronary heart disease

Basic Pathogenic Mechanisms and Epigenetic Players Promoted by Extracellular Vesicles in Vascular Damage

Extracellular Vesicles: The Future of Diagnosis in Solid Organ Transplantation?

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