Extracellular Vesicles as Mediators of Environmental and Metabolic Stress Coping Mechanisms During Mammalian Follicular Development

Gebremedhn, Samuel; Ali, Asghar; Gad, Ahmed; Procházka, Radek; Tesfaye, Dawit

doi:10.3389/fvets.2020.602043

Cited by 13 publications

(8 citation statements)

References 105 publications

(152 reference statements)

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“…Similarly, heat stress-related EVs induced adaptive responses in cultured bovine granulosa cells exposed to heat shock. This observation was evidenced by improved granulosa cell viability and decreased ROS accumulation and was mediated through transfer of HSP90, HSP70, NRF2, antioxidants, and several other microRNAs [121,122].…”

Section: Heat-shockmentioning

confidence: 92%

Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors

Alharbi

Lee

Abdelazim

et al. 2021

BioMed Research International

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Extracellular vesicles (EVs), like exosomes, are nanosized membrane-enveloped vesicles containing different bioactive cargo, such as proteins, lipids, mRNA, miRNA, and other small regulatory RNAs. Cell-derived EVs, including EVs originating from stem cells, may capture components from damaged cells or cells impacted by therapeutic treatments. Interestingly, EVs derived from stem cells can be preconditioned to produce and secrete EVs with different therapeutic properties, particularly with respect to heat-shock proteins and other molecular cargo contents. This behavior is consistent with stem cells that also respond differently to various microenvironments. Heat-shock proteins play roles in cellular protection and mediate cellular resistance to radiotherapy, chemotherapy, and heat shock. This review highlights the possible roles EVs play in mediating cellular plasticity and survival when exposed to different physical and chemical stressors, with a special focus on the respiratory distress due to the air pollution.

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Section: Heat-shockmentioning

confidence: 92%

Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors

Alharbi

Lee

Abdelazim

et al. 2021

BioMed Research International

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“…Especially, when exposed to external stress stimulus, cells always release more EVs outwards. Cells upon oxidative stress always undergo dynamic biological processes, including stimulating the generation and transport of MVBs 63,64 . It is supposed that the initiation of EVs biogenesis may account for the compensation of cellular homeostasis.…”

Section: Evs In Iron Homeostasis and Oxidative Stressmentioning

confidence: 99%

The role of extracellular vesicles in iron homeostasis and ferroptosis: Focus on musculoskeletal diseases

Liao

Tong

et al. 2023

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Iron homeostasis is crucial for maintaining proper cellular function, and its disruption is considered one of the pathogenic mechanisms underlying musculoskeletal diseases. Under conditions of oxidative stress, the accumulation of cellular iron overload and lipid peroxidation can lead to ferroptosis. Extracellular vesicles (EVs), serving as mediators in the cell‐to‐cell communication, play an important role in regulating the outcome of cell ferroptosis. Growing evidence has proven that EV biogenesis and secretion are tightly associated with cellular iron export. Furthermore, different sources of EVs deliver diverse cargoes to bring about phenotypic changes in the recipient cells, either activating or inhibiting ferroptosis. Thus, delivering therapies targeting ferroptosis through EVs may hold significant potential for treating musculoskeletal diseases. This review aims to summarize current knowledge on the role of EVs in iron homeostasis and ferroptosis, as well as their therapeutic applications in musculoskeletal diseases, and thereby provide valuable insights for both research and clinical practice.

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“…These results are undoubtedly promising, but also here, direct causative links between EVs characteristics and oocyte quality are still missing. Directly adding isolated EVs to the culture medium seems to be a promising approach (Asaadi et al 2021) to further study the rescuing and protective capacity of EVs against stressors in order to improve oocyte quality (Gebremedhn et al 2020).…”

Section: Extracellular Vesicles As Mediators Of Maternal Health To Th...mentioning

confidence: 99%

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!

Leroy

Meulders

Moorkens

et al. 2022

Reprod. Fertil. Dev.

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Reduced oocyte quality, mainly due to mitochondrial dysfunction, is a key cause of subfertility in patients with metabolic diseases such as obesity. Recent fundamental understanding of the underlying mechanisms highlights the importance of developing effective preconception care strategies not only to improve metabolic health, but also oocyte quality. Minimizing mitochondrial oxidative stress either in vivo or in vitro is a promising solution, however further investigations should consider the long-term consequences on epigenetic programming and offspring health.

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Extracellular Vesicles as Mediators of Environmental and Metabolic Stress Coping Mechanisms During Mammalian Follicular Development

Cited by 13 publications

References 105 publications

Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors

Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors

The role of extracellular vesicles in iron homeostasis and ferroptosis: Focus on musculoskeletal diseases

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!

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